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Mathematical model of the human colon - Inria

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The Human Colon Motivation <strong>Ma<strong>the</strong>matical</strong> <strong>model</strong> Validation framework Perspectives and Conclusions<br />

Interactions host-bacterial: starting<br />

to be understood<br />

Microbiota: role on <strong>human</strong> health<br />

Limitations in <strong>the</strong> experimentation:<br />

Uncultured bacteria<br />

Samples in some cases can not<br />

be representative: Ethical<br />

considerations<br />

An in silico <strong>model</strong> would<br />

be useful to:<br />

Improve <strong>the</strong> understanding <strong>of</strong> :<br />

Carbohydrate fermentation<br />

Impact <strong>of</strong> <strong>the</strong> microbiota on<br />

<strong>the</strong> stability <strong>of</strong> <strong>the</strong> digestive<br />

system<br />

Role <strong>of</strong> <strong>the</strong> microbiota on<br />

IBD, Obesity<br />

Study <strong>the</strong> influence <strong>of</strong> dietary<br />

regimes on <strong>human</strong><br />

gastrointestinal microbiota<br />

Design experiments both in vivo<br />

and in vitro

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