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Bridging the Gap - International Society Of Sports Nutrition

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• Posits that <strong>the</strong> spectrum of functions for a<br />

micronutrient are managed by <strong>the</strong> organism such<br />

that functions required short term survival take<br />

precedence over those whose loss can be better<br />

tolerated.<br />

• Done via binding constants and targeted tissue<br />

distribution<br />

• Provides rationale for why modest daily V/M<br />

deficiencies may increase risk of degenerative<br />

diseases.<br />

• Two supporting studies<br />

• Vitamin K<br />

• Selenium<br />

Ames BN PNAS 2006<br />

McCann& Ames AJCN 2009<br />

McCann & Ames FASEB 2012

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