Drug Coated Balloon Drug-Coated Balloon ... - summitMD.com

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Tissue Transfer and Retention Crystalline versus Amorphous Coatings Tissue Drug Concentration (%) 100.00 50.00 25.00 EFFECTIVE Crystalline Coating 1: higher uptake, higher retention 12.50 6.25 3.13 3.06 1.53 0.77 038 0.38 0.19 0.10 Amorphous Coating 3: higher uptake, lower retention Crystalline Coating 2: lower uptake, higher retention 1h 24h 7d 28d Time SAFE
Second Generations Coatings Paclitaxel Coated Balloon Technologies • Manual dipping process • Automated and controlled drug coating •Inconsistent D:E mixture •Improved coating mixture and uniformity First generation DCB technologies have already migrated into their second generation providing more precise coatings, tissue drug delivery and lower particulate count… •Limited scale production •Large scale reproducibility
Page 1 and 2: Drug-Coated Balloon Technologies I:
Page 3 and 4: Mechanism of Drug Delivery and Rest
Page 5 and 6: PACCOCATH ISR- F/U 5 Years Follow U
Page 7 and 8: Impact of Drug Retention (PK) on Va
Page 9 and 10: Mechanism of Action of DCB: Impact
Page 11: Paclitaxel Formulation Types Impact
Page 15 and 16: Fact #2: PCB May Have Limited Effic
Page 17 and 18: Vascular Healing of BMS-PCB Combina
Page 19 and 20: Fact #4: Sirolimus Analogues • Ra
Page 21 and 22: Drug Eluting Balloon Nanoparticle B
Page 23 and 24: Opportunities for Improvement SIROL

Drug Coated Balloon Drug-Coated Balloon ... - summitMD.com

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