Drug Coated Balloon Drug-Coated Balloon ... - summitMD.com

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Paclitaxel Irreversibly Inhibits Arterial SMC Proliferation and Migration Using a Single Dose Tissue Distribution and Retention of Paclitaxel Make it an Ideal Agent for Local Drug Delivery Control (hSMC) (+) anti–ß-tubulin Sirolimus Paclitaxel l (hSMC) Paclitaxel (+) anti–ß-tubulin Dextran Axel DI. Circulation. 1997;96:636-645 A. Levin et al., Proc NatlAcad Sci USA, 2004, 101, 9463-9467.
Drug Eluting Balloon Nanoparticle Based (Sirolimus) )B Balloon Dilatation ti System Nanoparticle delivery technology • Enhanced tissue penetration • Protection from rapid degradation • Controlled and sustained release • Complete degradation Angioplasty balloon dilation system • Fully integrated combination device •Semi-compliant balloon • Full range of sizes and diameters Regular dilatation pressures plus Sirolimus nanoparticle delivery 21 Slide courtesy (modified) of Caliber Therapeutics
Page 1 and 2: Drug-Coated Balloon Technologies I:
Page 3 and 4: Mechanism of Drug Delivery and Rest
Page 5 and 6: PACCOCATH ISR- F/U 5 Years Follow U
Page 7 and 8: Impact of Drug Retention (PK) on Va
Page 9 and 10: Mechanism of Action of DCB: Impact
Page 11 and 12: Paclitaxel Formulation Types Impact
Page 13 and 14: Second Generations Coatings Paclita
Page 15 and 16: Fact #2: PCB May Have Limited Effic
Page 17 and 18: Vascular Healing of BMS-PCB Combina
Page 19: Fact #4: Sirolimus Analogues • Ra
Page 23 and 24: Opportunities for Improvement SIROL

Drug Coated Balloon Drug-Coated Balloon ... - summitMD.com

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