3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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RNA sample 0 1 2 3 4 5 6 69 70 Time Stock solution: Q RNA-replicase, ATP, CTP, GTP and UTP, buffer D.R.Mills, R.L.Peterson, S.Spiegelman, An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc.Natl.Acad.Sci.USA 58 (1967), 217-224 Application of serial transfer to RNA evolution in the test tube
Reproduction of the original figure of the serial transfer experiment with Q RNA β D.R.Mills, R,L,Peterson, S.Spiegelman, An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc.Natl.Acad.Sci.USA 58 (1967), 217-224
Page 2 and 3: Evolutionary Dynamics A physicists
Page 4 and 5: 1. Charles Darwins pathbreaking tho
Page 6 and 7: Populations adapt to their environm
Page 8 and 9: time Charles Darwin, The Origin of
Page 10 and 11: The molecular clock of evolution Mo
Page 14 and 15: „Replication fork“ in DNA repli
Page 16 and 17: Kinetics of RNA replication C.K. Bi
Page 18 and 19: Stock solution: activated monomers,
Page 20 and 21: An example of ‘artificial selecti
Page 22 and 23: tobramycin RNA aptamer, n = 27 Form
Page 24 and 25: A ribozyme switch E.A.Schultes, D.B
Page 26 and 27: The sequence at the intersection: A
Page 28 and 29: Application of molecular evolution
Page 30 and 31: Results from evolution experiments:
Page 32 and 33: 1971 1977 1988 Chemical kinetics of
Page 34 and 35: Formation of a quasispecies in sequ
Page 36 and 37: Formation of a quasispecies in sequ
Page 38 and 39: Uniform distribution in sequence sp
Page 40 and 41: Error threshold: Individual sequenc
Page 42 and 43: Molecular evolution of viruses
Page 46 and 47: O 5' - end CH 2 O N 1 5'-end GCGGAU
Page 48 and 49: many genotypes one phenotype
Page 50 and 51: Motoo Kimuras population genetics o
Page 53 and 54: d H = 1 lim p→0 x1 ( p) = x2( p)
Page 55 and 56: Consensus sequence of a quasispecie
Page 57 and 58: Consensus sequence of a quasispecie
Page 61 and 62: Structure of randomly chosen initia
Page 63 and 64:
In silico optimization in the flow
Page 65:
Evolutionary trajectory Spreading o
Page 70 and 71:
Charles Darwin. The Origin of Speci
Page 72 and 73:
Acknowledgement of support Fonds zu
Page 74:
Web-Page for further information: h
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3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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