3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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28 neutral point mutations during a long quasi-stationary epoch Transition inducing point mutations change the molecular structure Neutral point mutations leave the molecular structure unchanged Neutral genotype evolution during phenotypic stasis
Evolutionary trajectory Spreading of the population on neutral networks Drift of the population center in sequence space
Page 2 and 3:
Evolutionary Dynamics A physicists
Page 4 and 5:
1. Charles Darwins pathbreaking tho
Page 6 and 7:
Populations adapt to their environm
Page 8 and 9:
time Charles Darwin, The Origin of
Page 10 and 11:
The molecular clock of evolution Mo
Page 12 and 13:
RNA sample 0 1 2 3 4 5 6 69 70 Time
Page 14 and 15: „Replication fork“ in DNA repli
Page 16 and 17: Kinetics of RNA replication C.K. Bi
Page 18 and 19: Stock solution: activated monomers,
Page 20 and 21: An example of ‘artificial selecti
Page 22 and 23: tobramycin RNA aptamer, n = 27 Form
Page 24 and 25: A ribozyme switch E.A.Schultes, D.B
Page 26 and 27: The sequence at the intersection: A
Page 28 and 29: Application of molecular evolution
Page 30 and 31: Results from evolution experiments:
Page 32 and 33: 1971 1977 1988 Chemical kinetics of
Page 34 and 35: Formation of a quasispecies in sequ
Page 36 and 37: Formation of a quasispecies in sequ
Page 38 and 39: Uniform distribution in sequence sp
Page 40 and 41: Error threshold: Individual sequenc
Page 42 and 43: Molecular evolution of viruses
Page 44 and 45: 1. Charles Darwins pathbreaking tho
Page 46 and 47: O 5' - end CH 2 O N 1 5'-end GCGGAU
Page 48 and 49: many genotypes one phenotype
Page 50 and 51: Motoo Kimuras population genetics o
Page 53 and 54: d H = 1 lim p→0 x1 ( p) = x2( p)
Page 55 and 56: Consensus sequence of a quasispecie
Page 57 and 58: Consensus sequence of a quasispecie
Page 59 and 60: 1. Charles Darwins pathbreaking tho
Page 61 and 62: Structure of randomly chosen initia
Page 63: In silico optimization in the flow
Page 70 and 71: Charles Darwin. The Origin of Speci
Page 72 and 73: Acknowledgement of support Fonds zu
Page 74: Web-Page for further information: h
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3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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