3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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1. Charles Darwins pathbreaking thoughts 2. Evolution without cellular life 3. Chemical kinetics of molecular evolution 4. Consequences of neutrality 5. Modeling optimization of molecules
What is neutrality ? Selective neutrality = = several genotypes having the same fitness. Structural neutrality = = several genotypes forming molecules with the same structure.
Page 2 and 3: Evolutionary Dynamics A physicists
Page 4 and 5: 1. Charles Darwins pathbreaking tho
Page 6 and 7: Populations adapt to their environm
Page 8 and 9: time Charles Darwin, The Origin of
Page 10 and 11: The molecular clock of evolution Mo
Page 12 and 13: RNA sample 0 1 2 3 4 5 6 69 70 Time
Page 14 and 15: „Replication fork“ in DNA repli
Page 16 and 17: Kinetics of RNA replication C.K. Bi
Page 18 and 19: Stock solution: activated monomers,
Page 20 and 21: An example of ‘artificial selecti
Page 22 and 23: tobramycin RNA aptamer, n = 27 Form
Page 24 and 25: A ribozyme switch E.A.Schultes, D.B
Page 26 and 27: The sequence at the intersection: A
Page 28 and 29: Application of molecular evolution
Page 30 and 31: Results from evolution experiments:
Page 32 and 33: 1971 1977 1988 Chemical kinetics of
Page 34 and 35: Formation of a quasispecies in sequ
Page 36 and 37: Formation of a quasispecies in sequ
Page 38 and 39: Uniform distribution in sequence sp
Page 40 and 41: Error threshold: Individual sequenc
Page 42 and 43: Molecular evolution of viruses
Page 46 and 47: O 5' - end CH 2 O N 1 5'-end GCGGAU
Page 48 and 49: many genotypes one phenotype
Page 50 and 51: Motoo Kimuras population genetics o
Page 53 and 54: d H = 1 lim p→0 x1 ( p) = x2( p)
Page 55 and 56: Consensus sequence of a quasispecie
Page 57 and 58: Consensus sequence of a quasispecie
Page 59 and 60: 1. Charles Darwins pathbreaking tho
Page 61 and 62: Structure of randomly chosen initia
Page 63 and 64: In silico optimization in the flow
Page 65: Evolutionary trajectory Spreading o
Page 70 and 71: Charles Darwin. The Origin of Speci
Page 72 and 73: Acknowledgement of support Fonds zu
Page 74: Web-Page for further information: h

3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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