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• Glucose-6-P may enter Glycolysis or (mainly in liver) be dephosphorylated for release to the blood. • Liver Glucose-6-phosphatase catalyzes the following, essential to the liver's role in maintaining blood glucose: glucose-6-P + H 2 O glucose + P i • Most other tissues lack this enzyme.
<strong>Glycogen</strong> Synthesis Glucose units are activated for transfer by formation of sugar nucleotides • What are other examples of "activation"? – acetyl-CoA, biotin, THF, • Leloir showed in the 1950s that glycogen synthesis depends on sugar nucleotides • UDP-glucose pyrophosphorylase – a phosphoanhydride exchange – driven by pyrophosphate hydrolysis
Page 1 and 2: Carbohydrate metabolism III
Page 3: Glycogen Catabolism Getting glucose
Page 6 and 7: Metabolism of Tissue Glycogen Diges
Page 9 and 10: Glycogen Phosphorylase (GP) • Pyr
Page 12 and 13: Debranching enzyme • Debranching
Page 16 and 17: Glycogen Synthesis • Uridine diph
Page 18 and 19: Glycogen Synthase Forms -(1 4) glyc
Page 20 and 21: Glycogen Synthase • Glycogen Synt
Page 23 and 24: Control of Glycogen Metabolism A hi
Page 25 and 26: Regulation of GP • Glycogen Synth
Page 27 and 28: Enzyme Cascades and GP/GS Hormonal
Page 29 and 30: Epinephrine and Glucagon The differ
Page 31: Hormonal Regulation of Glycogen Syn
Page 35 and 36: Other Substrates for Glycolysis Fru
Page 37 and 38: Sucrose (Table Sugar) O- -D-Glucopy
Page 39 and 40: Liver Metabolism of Fructose I (Lit
Page 41 and 42: Liver Metabolism of Fructose III
Page 43 and 44: Metabolism of galactose • Source
Page 45 and 46: Phosphorylation of Galactose
Page 47 and 48: Epimerization of UDP-Galactose Why
Page 49 and 50: The Role of Glucuronic acid • Uri
Page 51: Transformation of glucose-6-P fosfa

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