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Phosphorylation of GP and GS Covalent control • Edwin Krebs and Edmond Fisher showed in 1956 that a "converting enzyme" converted phosphorylase „b“ to phosphorylase „a“ (P) • Nine Ser residues on GS are phosphorylated!
Enzyme Cascades and GP/GS Hormonal regulation • Hormones (glucagon, epinephrine) activate adenylyl cyclase • cAMP activates kinases and phosphatases that control the phosphorylation of GP and GS • GTP-binding proteins (G proteins) mediate the communication between hormone receptor and adenylyl cyclase
Page 1 and 2: Carbohydrate metabolism III
Page 3: Glycogen Catabolism Getting glucose
Page 6 and 7: Metabolism of Tissue Glycogen Diges
Page 9 and 10: Glycogen Phosphorylase (GP) • Pyr
Page 12 and 13: Debranching enzyme • Debranching
Page 14 and 15: • Glucose-6-P may enter Glycolysi
Page 16 and 17: Glycogen Synthesis • Uridine diph
Page 18 and 19: Glycogen Synthase Forms -(1 4) glyc
Page 20 and 21: Glycogen Synthase • Glycogen Synt
Page 23 and 24: Control of Glycogen Metabolism A hi
Page 25: Regulation of GP • Glycogen Synth
Page 29 and 30: Epinephrine and Glucagon The differ
Page 31: Hormonal Regulation of Glycogen Syn
Page 35 and 36: Other Substrates for Glycolysis Fru
Page 37 and 38: Sucrose (Table Sugar) O- -D-Glucopy
Page 39 and 40: Liver Metabolism of Fructose I (Lit
Page 41 and 42: Liver Metabolism of Fructose III
Page 43 and 44: Metabolism of galactose • Source
Page 45 and 46: Phosphorylation of Galactose
Page 47 and 48: Epimerization of UDP-Galactose Why
Page 49 and 50: The Role of Glucuronic acid • Uri
Page 51: Transformation of glucose-6-P fosfa

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