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Control of <strong>Glycogen</strong> Metabolism<br />

A highly regulated process, involving reciprocal control of<br />

glycogen phosphorylase and glycogen synthase<br />

• GP allosterically activated by AMP and<br />

inhibited by ATP, glucose-6-P and<br />

caffeine<br />

• GS is stimulated by glucose-6-P<br />

• Both enzymes are regulated by<br />

covalent modification - phosphorylation

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