Hirsutism & Virilization

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III- 5 α-Reductase • 5 α-Reductase converts testosterone to dihydrotestosterone (DHT) in androgensensitive tissues such as hair follicles and skin. • Levels of this enzyme are significantly elevated in the skin of hirsuted women compared with non hirsuted. • The enzyme activity is partly stimulated by elevated circulating testosterone levels. • Dihydrotestosterone is responsible for stimulating hair growth and is two to three times as potent as testosterone.
Causes of Hirsuitism PCOS 75% Idiopatic hirsutism 15% Adrenal hyperplasia 3% Cushing’s disease 1% Hyperprolactinemia 1% Tumor of the ovary 1% Tumor of the adrenal 0,1% Medications 1%
Page 2 and 3: By Prof.Dr. Nabil Lymon Head of Int
Page 4 and 5: Virilization: • Is hirsutism asso
Page 6 and 7: Types of Hair 1. Lanugo hair: It is
Page 8 and 9: 2. Degree to which hair follicles a
Page 10 and 11: Sources of androgens in females:
Page 12 and 13: I- Testosterone • Total testoster
Page 14 and 15: II- Sex Hormone-Binding Globulin (S
Page 18 and 19: Diagnosis of Hirsutism
Page 20 and 21: 2) Presence or absence of virilizat
Page 22 and 23: Differential Diagnosis of Hirsutism
Page 24 and 25: a) The fundamental pathophysiologic
Page 26 and 27: 2- Idiopathic hirsutism: • This c
Page 28 and 29: 4- Cushing syndrome: • Adrenocort
Page 30 and 31: 6- Disorders of pituitary origin
Page 32 and 33: Laboratory Evaluation of Hirsutism
Page 34 and 35: 2) Serum DHEAS (a marker of adrenal
Page 36 and 37: 5) Oestrogen levels. Estradiol is u
Page 38 and 39: Treatment
Page 40 and 41: • Suppression of androgen synthes
Page 42 and 43: • Androgen-receptor blockers: •

Hirsutism & Virilization

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