Hirsutism & Virilization

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• Androgen-receptor blockers: • Action: (--) binding of DHT to androgen receptor. • Types: • Others: • Spironolactone (aldosterone antagonist) • Flutamide. • Cyproterone acetate. • Cimetidine: androgen receptor blocker. • Ketoconazole: (--) adrenal & ovarian androgen synthesis. • Insulin-senstizing agents: e.g, metformin • 5a-reductase inhibitors.
• Supportive measures: • Shaving, tweezing, waxing, and use of depilatories temporary measures, which may need to be repeated daily. • Bleaching is effective for mild hair growth. • Electolysis: permanent destruction of hair follicles: Multiple treatment are needed. • Laser epilation: provides directed damage to hair follicles, which temporarily or permanently remove terminal hair, can be used over a larger area.
Page 2 and 3: By Prof.Dr. Nabil Lymon Head of Int
Page 4 and 5: Virilization: • Is hirsutism asso
Page 6 and 7: Types of Hair 1. Lanugo hair: It is
Page 8 and 9: 2. Degree to which hair follicles a
Page 10 and 11: Sources of androgens in females:
Page 12 and 13: I- Testosterone • Total testoster
Page 14 and 15: II- Sex Hormone-Binding Globulin (S
Page 16 and 17: III- 5 α-Reductase • 5 α-Reduct
Page 18 and 19: Diagnosis of Hirsutism
Page 20 and 21: 2) Presence or absence of virilizat
Page 22 and 23: Differential Diagnosis of Hirsutism
Page 24 and 25: a) The fundamental pathophysiologic
Page 26 and 27: 2- Idiopathic hirsutism: • This c
Page 28 and 29: 4- Cushing syndrome: • Adrenocort
Page 30 and 31: 6- Disorders of pituitary origin
Page 32 and 33: Laboratory Evaluation of Hirsutism
Page 34 and 35: 2) Serum DHEAS (a marker of adrenal
Page 36 and 37: 5) Oestrogen levels. Estradiol is u
Page 38 and 39: Treatment
Page 40 and 41: • Suppression of androgen synthes

Hirsutism & Virilization

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