Skin Biomarkers as objective measures of stratum corneum barrier

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Biomarkers Indicative of Stratum Corneum Health Stratum Corneum Quality & Health Objective Biomarker Barrier Quality Keratin 1,10,11 Barrier Integrity and Cohesion Total Protein Dryness Induced Irritation and Redness Hydration IL1-ra/IL1-α Pyrrolidone Carboxylic Acid (PCA)
Biomarker Sampling and Analysis Approach “Non-invasive sampling of stratum corneum” Sampling Sites ● Leg ● Arm ● Targeted Multiple Analyte Assay - Multiplexed ELISA - LC/MS/MS ● Colorimetric Assay for Protein - normalize targeted analyte data 1) Apply D-Squame Tape 2) Remove Tape 3) Extract Analytes 4) Analysis Samples
Page 1 and 2: SKIN BIOMARKERS AS OBJECTIVE MEASUR
Page 3: Objectives • Develop a set of ski
Page 7 and 8: Winter vs. Summer: Traditional Meas
Page 9 and 10: Winter vs. Summer: Total Protein T
Page 11 and 12: Winter vs. Summer: Pyrrolidone Carb
Page 13 and 14: Advanced Body Wash: Keratin 1, 10,
Page 15 and 16: Regular Body Wash: IL1ra:IL1αRatio
Page 17 and 18: Skin Biomarker Summary Biomarkers S
Page 19 and 20: References 1. Engelke M, Jensen JM,

Skin Biomarkers as objective measures of stratum corneum barrier

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