Skin Biomarkers as objective measures of stratum corneum barrier

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Protocol • Standard Leg-Controlled-Application Testing (LCAT) protocol 2 was used in this study with a minimum dryness entrance criteria of 2.0 (0-5 scale, 0=no dryness) during winter season. • The following products were applied once a day. – Leave-on lotion containing petrolatum; – Advanced petrolatum-depositing body wash; – Regular body wash containing sodium laureth sulfate, sodium lauryl sulfate and cocamidopropyl betaine. • A total of ten consecutive tape strips were taken for biomarker analysis at the baseline and at week 1, 2, and 3 of product usages, respectively. • The same panelists returned in the summer and their skin biomarkers were measured to understand seasonal effect.
Winter vs. Summer: Traditional Measures Measures Winter Summer P values for (n=27) (n=27) pair wise comparison Dryness (mean) 2.8 ± 0.2 1.7 ± 0.2 P
Page 1 and 2: SKIN BIOMARKERS AS OBJECTIVE MEASUR
Page 3 and 4: Objectives • Develop a set of ski
Page 5: Biomarker Sampling and Analysis App
Page 9 and 10: Winter vs. Summer: Total Protein T
Page 11 and 12: Winter vs. Summer: Pyrrolidone Carb
Page 13 and 14: Advanced Body Wash: Keratin 1, 10,
Page 15 and 16: Regular Body Wash: IL1ra:IL1αRatio
Page 17 and 18: Skin Biomarker Summary Biomarkers S
Page 19 and 20: References 1. Engelke M, Jensen JM,

Skin Biomarkers as objective measures of stratum corneum barrier

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