Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham

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• EGCG prevents UVB-induced immune suppression, and UVB-induced immune suppression is considered as a risk factor for the development of non-melanoma skin cancer. • We have also shown that inhibition of UVBinduced immunosuppression in mice by EGCG is associated with the increased levels of IL-12. Carcinogenesis, 20: 2117-2124, 1999. • IL-12 has anti-tumor activity and DNA repair ability. Therefore,
Hypothesis • We hypothesize that chemopreventive effect of EGCG against photocarcinogenesis is mediated through IL-12.
Page 1 and 2: September 11, 2006; Botanicals Work
Page 3 and 4: • The skin is one of the largest
Page 5 and 6: Causes of Skin Cancer • Following
Page 7 and 8: Multi-stage carcinogenesis model sh
Page 9 and 10: UV Radiation and Facts • Although
Page 11 and 12: Dietary supplements may have the ab
Page 13: Topical application of (-)-epigallo
Page 17 and 18: EGCG inhibits UVB-induced tumor mul
Page 19 and 20: EGCG inhibits tumor growth greater
Page 21 and 22: EGCG reduces or repairs UV-induced
Page 23 and 24: UV-induced Sunburn Cells • The fo
Page 25 and 26: EGCG Repairs UVB-induced CPDs in XP
Page 27 and 28: Conclusion • EGCG from green tea
Page 29 and 30: Working Support • Anshu Mittal, P

Santosh K. Katiyar, Ph.D. - University of Alabama at Birmingham

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