AlumniBulletin - The University of Alabama at Birmingham
AlumniBulletin - The University of Alabama at Birmingham
AlumniBulletin - The University of Alabama at Birmingham
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PROGRAMS WORTH SUPPORTING:<br />
<strong>The</strong> Nancy R. and Eugene C. Gwaltney<br />
Family Endowed Chair in Medical Research<br />
By Dawn Mesa<br />
Ask Eric J. Sorscher, M.D.,<br />
about the research currently taking<br />
place under his direction <strong>at</strong> the<br />
Gregory Fleming James Cystic<br />
Fibrosis Research Center <strong>at</strong> UAB,<br />
and it quickly becomes apparent<br />
th<strong>at</strong> the center’s work revolves<br />
around p<strong>at</strong>ients.<br />
“<strong>The</strong> center focuses on understanding<br />
the basic mechanisms <strong>of</strong><br />
cystic fibrosis [CF], why people with<br />
CF get sick—from the gene th<strong>at</strong>’s<br />
functioning improperly, to ways in<br />
which th<strong>at</strong> gene’s expression influences<br />
cells, to the way those cells are<br />
involved in the disease process,” says<br />
Sorscher. “An awful lot <strong>of</strong> wh<strong>at</strong> we<br />
do is research directed toward new<br />
therapies. When we have an idea<br />
about something th<strong>at</strong> might benefit<br />
p<strong>at</strong>ients as quickly as possible, we try<br />
to test it in the clinic.”<br />
With a very active group <strong>of</strong><br />
researchers who are both scientists<br />
and clinicians, the center has a strong<br />
team th<strong>at</strong> is capable <strong>of</strong> quickly taking<br />
new therapeutic approaches into the<br />
clinic. This activity has led to the<br />
public<strong>at</strong>ion <strong>of</strong> numerous articles on<br />
research findings. Recently, the faculty<br />
in the center published a study in<br />
the Journal <strong>of</strong> Pedi<strong>at</strong>rics on a new<br />
drug therapy th<strong>at</strong> led to weight gain<br />
and improved lung function for CF<br />
sufferers. <strong>The</strong> center has also published<br />
the results <strong>of</strong> a gene-therapy<br />
trial, outlining some <strong>of</strong> the challenges<br />
th<strong>at</strong> will be faced in genetherapy<br />
tre<strong>at</strong>ments for cystic fibrosis<br />
and CF p<strong>at</strong>ients.<br />
An additional study, which used<br />
an approach to CF therapy developed<br />
by UAB microbiologist David M.<br />
Bedwell, Ph.D., has shown th<strong>at</strong> for a<br />
subset <strong>of</strong> p<strong>at</strong>ients with a specific form<br />
<strong>of</strong> CF, it’s possible to correct the problem<br />
in the nasal airways. One <strong>of</strong> the<br />
UAB investig<strong>at</strong>ors, Szuszanna Bebok,<br />
M.D.—in collabor<strong>at</strong>ion with CF<br />
researchers in Israel who have many<br />
p<strong>at</strong>ients with this particular form <strong>of</strong><br />
the disease—will soon publish the<br />
results <strong>of</strong> this study in the New<br />
England Journal <strong>of</strong> Medicine.<br />
<strong>The</strong> center is also a member <strong>of</strong> a<br />
select n<strong>at</strong>ionwide group th<strong>at</strong> tests<br />
the l<strong>at</strong>est therapies in CF tre<strong>at</strong>ment.<br />
Currently, it is the lead center for a<br />
multicenter trial in particular str<strong>at</strong>egies<br />
being explored by Bedwell and<br />
pedi<strong>at</strong>rician John Paul Clancy,<br />
M.D. “All <strong>of</strong> the newest therapies<br />
are being tested in <strong>Birmingham</strong>,”<br />
says Sorscher. For instance, when<br />
azithromycin was announced last<br />
year as a new means <strong>of</strong> tre<strong>at</strong>ing the<br />
lung infections th<strong>at</strong> CF p<strong>at</strong>ients<br />
<strong>of</strong>ten get, UAB was one <strong>of</strong> the sites<br />
th<strong>at</strong> was integral to the trial. “It<br />
looks as if this medic<strong>at</strong>ion will be<br />
very beneficial to certain people<br />
with cystic fibrosis,” he says.<br />
Sorscher emphasizes two things<br />
about the CF research in the center:<br />
“<strong>The</strong> fact th<strong>at</strong> UAB has an outstanding<br />
ability to grasp the fundamental<br />
science—understanding<br />
the CF gene and its function in<br />
cells—and the outstanding group<br />
<strong>of</strong> people in the center who can<br />
take th<strong>at</strong> science and move it to<br />
p<strong>at</strong>ients as quickly as possibly in a<br />
rigorous, high-scrutiny fashion.<br />
<strong>The</strong> system here makes it possible<br />
to ‘settle’ the issue as to whether<br />
there is potential in a particular<br />
therapy or medic<strong>at</strong>ion for helping<br />
people who suffer from CF.”<br />
For inform<strong>at</strong>ion on contributing<br />
to <strong>The</strong> Nancy R. and Eugene<br />
C. Gwaltney Family Endowed<br />
Chair in Medical Research, please<br />
contact John Lankford, Ph.D., <strong>at</strong><br />
(205) 975-7341, or see the envelope<br />
enclosed in this issue.<br />
A RECEPTION IN POINT CLEAR<br />
Gerhard Boehm, M.D., and his wife, Linda, along with Arthur Corte and his<br />
wife, Beverly, hosted a reception for alumni, residents, fellows, and friends to meet<br />
William B. Deal, M.D., vice president and dean <strong>of</strong> the UASOM. <strong>The</strong> event was<br />
held <strong>at</strong> the home <strong>of</strong> Dr. and Mrs. Boehm in Point Clear, <strong>Alabama</strong>, on Wednesday,<br />
May 7, 2003. Guests from Mobile and Baldwin Counties <strong>at</strong>tended the event.<br />
Deal expressed a desire to <strong>of</strong>fer alumni, residents, fellows, and friends an opportunity<br />
for membership in an elite group called the Dean’s Partners, a group committed<br />
to reinforcing the financial backbone <strong>of</strong> the School <strong>of</strong> Medicine. More<br />
specifically, Deal envisions the Partners providing the necessary funds to sustain the<br />
UASOM’s n<strong>at</strong>ional reput<strong>at</strong>ion and ensuring its future by <strong>at</strong>tracting and providing<br />
scholarship support to bright and talented young men and women.<br />
Dean’s Partners are asked to invest in the School <strong>of</strong> Medicine by contributing<br />
annually. If you would like to become a member, please see the pledge card<br />
<strong>at</strong>tached in this issue or contact Meredith Murdock <strong>at</strong> (205) 934-4469.<br />
(Counterclockwise from top left) Betty Ruth Spier, M.D., and David G. Walsh, M.D.;<br />
William R. Staggers, M.D., and William B. Deal, M.D.; Hosts Gerhard A.W. Boehm,<br />
M.D. (left), and A. Arthur Corte (right) with Deal; Bobette (Mrs. Lowell J.) Friedman<br />
and Angus Cooper; Alumni and friends <strong>of</strong> the UASOM.<br />
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