Coda® Lo-Boy - IVFOnline.com

Coda Air ®
The only clinically tested and proven filtration technology for
safe use in IVF laboratories.
Good Air is Good Medical Practice
Air quality in the incubator and the lab is an
important factor for embryo development.
Protect Embryos
…Embryos do not have an “immune system”
• VOCs can have significant detrimental effects on embryos.
• VOCs are too small to be trapped by HEPA filters.
• Coda ® filters are common-sense safety devices that serve to
protect embryos from unforeseen Volatile Organic Contaminants
(VOCs) and other contaminants.
Common VOCs found inside incubators, such as, Benzene,
Acetone, Ethanol, and Formaldehyde are 100 to 1000 times smaller
than the pore size of the HEPA filter.

Why Should You Use Coda ® ?
Extensive studies and testing of incubators have shown that air inside incubators contains 6X more VOCs than outside
air. The incubators and other environmental chambers behave as a stand-alone micro-environment and, therefore, have
their own unique levels of contaminants, Volatile Organic Contaminants (VOCs), Chemical Air Contaminants (CACs),
vapors, solvents, micro-organisms, endotoxins, and particulates.
Coda ® has been introduced since
1997 and has been the only
technology with significant impact
on IVF results. Coda ® has proven to
increase implementation and
pregnancy rates by 5–25% overall or
by 6% on average in clinics
worldwide.
Coda ® installation is now becoming
a standard and required practice for
most IVF labs. More than 500
leading IVF clinics worldwide are
using Coda ® technology and have
reported increased results.
In addition, the patient population
is becoming more aware of the
impact of the air quality on embryo
development and pregnancy
results. The patient population has
recognized Coda ® products as a
necessary technology for the
protection and improvement of the
embryo culture environment and
results.
Coda ® 2
Coda ® 2 Kit
C2KT-107
C2KT-106 (w/o Coda® Xtra Inline® Filter)

Protect Embryos
…Embryos do not have an “immune system”
• VOCs can have significant detrimental effects on embryos.
• VOCs are too small to be trapped by HEPA filters.
• Coda ® filters are common-sense safety devices that serve to protect embryos from
unforeseen Volatile Organic Contaminants (VOCs) and other contaminants.
Common VOCs found inside incubators, such as, Benzene,
Acetone, Ethanol, and Formaldehyde are 100 to 1000 times
smaller than the pore size of the HEPA filter.
Air contaminants present in research and clinical
laboratories interact with specimens, samples, tissues,
media and oils. Studies show that Chemical Air
Contaminants (CACs) and Volatile Organic
Contaminants (VOCs) introduced from many sources
may seriously distort your results. The Coda ® Air and
Gas Filtration System can maximize the air quality of
your incubators and laboratories by removing up to
99.97% of these contaminants. The following table shows
the filtration power of the Coda ® System compared to
existing HVAC systems and HEPA filters used with your
equipment. HEPA filters are designed to stop materials
down to 0.3 microns.
μg/m 3
25
20
15
10
5
Benzene
Toluene
Xylenes
Styrene
0
Outside air
Return air
Hallways
Procedure
Room
Laminar
flow units
Incubators
Volatile Organic Contaminants in Air Outside and Inside an ART Laboratory
(Cohen et al., Human Reprod. 12, 1742-1749, 1997)
HEPA filters are designed to stop materials down to
0.3 microns. Unfortunately many of the gases found in IVF
labs; benzene, acetone, ethanol, formaldehyde, etc; are 100 to
1000 times smaller than the pore size of the HEPA filter. If
improving results is your goal, then Coda ® is the solution. For
more information call IVFonline or visit our website at
www.IVFonline.com.
FDA 510(k) Cleared ISO13485:2003 ISO9001:2000
Laboratories
Gas Lines
Incubators

Coda ® Air Technology
Coda ® VOC Filtration Technology for Laboratories, Incubators and Gas Lines
Coda ® – the only Proven VOC Filtering Technology for ART
Coda Tower ® ECO TM
GECO-009/115
GECO-009/230
Coda Tower ® ECO TM & Lo-Boy Filter Kits
GESA-001 Coda® Canister ECO TM Semi-Annual Kit
GEAK-001 . . . . . . . .Coda® Canister ECO TM Annual Kit
CCLS-082 . . . . . . . .Coda® Canister Lo-Boy Semi-Annual Kit
CCLA-082 . . . . . . . .Coda® Canister Lo-Boy Annual Kit
Coda ® Unit
GCIU-010
Coda ® Lo-Boy
GXTU-042/115
GXTU-042/230
Coda ® Aero
GCAU-010/115
GCAU-010/230
Coda ® Aero Filters
GCAF-001 . . . . .Pkg of 1
GCAF-002 . . . . .Pkg of 2
Coda ® 2 Kit
C2KT-107
C2KT-106 (w/o Coda® Xtra Inline® Filter)
Why Should You Use Coda ® ?
As you know your specimens spend all their time inside your incubators and its stand-alone
micro-environment. They are subject to unique levels of contaminants, Volatile Organic
Contaminants (VOCs), Chemical Air Contaminants (CACs), vapors, solvents, microorganisms,
endotoxins, bacteria, viruses and particulates. The air inside incubators contains 6
times the contaminants of the outside air. Installing a Coda ® inside your incubator creates a
perfectly controllable air environment and constantly circulates the air and removes VOCs
such as Styrene, Acetone, Benzene, Toluene, Octane, n-Decane, Freon, aldahydes, Nonane,
Methylcyclohexane and Butane present in most incubators and laboratory environment.
Coda ® SP
GCSP-010
The following are some of the common sources of air contamination inside incubators and
laboratories in general.
• Everytime you open an incubator the air contaminants such as VOCs and particulates
present in any laboratory environment will enter and reside inside your incubator.
• The incoming incubator gas lines such as CO2, N2 , or trigas contain VOCs and
particulates that may contaminate your incubator.
• All Dishes or plasticware placed inside your incubator release high levels of styrene
and other VOCs.
• Equipment and furniture off-gassing. For example, aldehydes are released from
formica materials.
• New incubator materials release VOCs. New incubators have especially high
levels of VOCs which you can smell easily. This will impact culture results in a
new incubator.
• Unexpected contamination in the air surrounding the building or the laboratory
sourced from general outside air pollution such as car exhausts, industry,
packaging and insulation, construction, adhesives and paints, demolition, and
waste will unexpectedly penetrate into the laboratory and the incubator.
Coda ® Xtra Inline ® Filters
GILX-001 . . . . . . .Pkg of 1
GILX-006 . . . . . . .Pkg of 6
GILX-012 . . . . . . .Pkg of 12
Coda ® Inline ® Filters
GILF-001 . . . . . . .Pkg of 1
GILF-006 . . . . . . .Pkg of 6
GILF-012 . . . . . . .Pkg of 12
Coda ® Filters
GCIF-001 . . . . .Pkg of 1
GCIF-006 . . . . .Pkg of 6
GCIF-012 . . . . .Pkg of 12
Coda ® has been used successfully worldwide, and has been proven to reduce the
contamination levels of most gasses by up to 500% and in some cases virtually eliminate
unwanted VOCs.
FDA 510(k) Cleared ISO13485:2003 and ISO9001:2000
Coda ® Passthru Device
GCPT-050

Introducing the Coda ® 2
Proven Filtration Technology to remove contaminants such as Volatile Organic
Contaminants (VOCs) inside incubators
…Common Sense Safety Devices to Protect Embryos, Stem Cells or any other Cell Culture
The Coda ® Incubator Unit has proven itself in human IVF for the past two decades to remove Volatile Organic
Contaminants (VOCs) presents in any incubator or laboratory.
Coda ® 2
Placed on the top shelf of the incubator
Coda ® Unit
Placed on the top shelf of
the incubator
Coda ® 2 Kit
C2KT-107
C2KT-106 (w/o Coda® Xtra Inline® Filter)
Available as an economical start up Kit for incubator
and gas line: with 6 months supply of Coda ® Filters,
1 Coda ® Xtra Inline ® Filter and accessories.
Coda ® SP
Mounted into the access
hole of your incubator
CodaInside
Coda ® Inside your incubator has proven to remove VOCs and
CACs. Particulates that can potentially inhibit any cell culture
development. Testing in certain laboratories has shown that in
the presence of formaldahydes even the mouse cell culture was
inhibited. Coda ® is a patented technology, manufactured by a
certified ISO medical company and each building material is
tested for any off-gassing and safe use in human embryos. Coda ®
includes activated carbon filtration and a 99.997 % HEPA filter to remove VOCs and CACs and particulates completely
from the air inside your environment. This will improve your embryo and stem cell quality and development, along
with giving you better overall performance and results. Our Coda ® 2 is ‘greener’, saves energy and is made of 100%
recyclable materials.
Do you know what VOCs reside inside your incubators?
styrene, methylcyclohexane, acetone, benzene, n-Decane, octane, etc.
Coda …the only solution introduced since 1997
FDA 510(k) Cleared

Coda ® Lo-Boy
Better utilization of space with horizontal air flow.
The Coda ® Lo-Boy is a compact state-of-the art air purification and
filtration system designed to bring the air quality to the max in
your laboratory and other work areas.
The Coda ® Lo-Boy is the ONLY one of its kind in the market today,
designed to remove all the Volatile Organic Contaminants (VOCs),
Chemical Air Contaminants (CACs), odors, molds, and particulate
present in the air.
The Coda ® Lo-Boy has a specially designed Four-Stage Filtration
System. Our new Canister System consists of a Pre-filter, a Second
Stage Filter, 5 Canister Main Stage Filters, and a Fourth Stage HEPA
filter. These filters only need to be changed twice a year and remove
even more VOCs and CACs from the air. The Coda®
Lo-Boy maintains the lowest noise level in the industry today.
Coda Tower ® Results
Coda ® Lo-Boy
Coda ® Lo-Boy Annual Kit Consists of:
• 5 Coda ® Canisters on frame
• 1 Coda ® HEPA Filter
• 2 Coda ® PreFilters
Cat # CCLA-082
Coda ® Lo-Boy Semi-Annual Kit Consists of:
• 5 Coda ® Canisters on frame
• 2 Coda ® PreFilters
Cat # CCLS-082
©1998 Patented
• Proven in IVF Labs Worldwide
• Proven to Increase Success Rates
• Effective Coverage of up to 400 Square Feet
• 3 Year Warranty
The Coda ® Aero is a technology that is designed to improve the air health
conditions in your IVF laboratories and workspace. Our Coda ® Technology
reduces particulates, harmful Volatile Organic Contaminants (VOCs) and
Chemical Airborne Contaminants (CACs).
Our specially designed HEPA filter removes 99.97% of contaminants and is
combined with our unique blend of activated carbon and alumina impregnated
with potassium permanganate for optimum absorption and oxidation of a wide
variety of gases and particulate contaminants.
Coda ® is the ‘First’ product in laboratory air purification and has been the most successful for the last 10 years.
Our 270° design allows the Coda ® Aero to be placed anywhere in the room. The variable speed fan allows YOU to
adjust the speed to accommodate your room size and air flow. The air flow pattern will remain effective at ALL speeds
and will work to CLEAR the air.
Buy a name you can trust…Coda ® Aero

Coda ® Xtra Inline ® Filters
Improved, more effective and economical due to an
increased size and amount of pure filtering materials, with
more amplified residence contact time and absorption
capacity.
Your first line of defense in removing contaminants such
as Volatile Organic Contaminants (VOCs) and Chemical
Air Contaminants (CACs) from incoming gas sources.
Coda ® Inline ® Filters have proven over 10 years to be safe and
effective in Human IVF in purifying the gas for incubators, reducing
contaminants and helping to improve results.
The Coda ® Xtra Inline ® Filter protects the air and environment inside your
incubator from harmful contaminants present in your gas sources ending up
in your incubator, by removing all Volatile Organic Contaminants (VOCs),
Chemical Air Contaminants (CACs) and particulates which may be in the gas
or reside in the old tanks and tubing.
Coda ® Inline ® Filters are the ‘only’ filter proven Safe and Effective in IVF and
Human Reproduction.
Coda ® Xtra Inline ® Filters are a proven quality product.
• Your first line of defense in removing contaminants such as Volatile
Organic Contaminants (VOCs) and Chemical Air Contaminants (CACs)
from incoming gas sources.
• Contains 100% clean activated carbon and a 99.997% HEPA filter
system.
• Made in the USA with tested proven materials.
• Proven in over 600 labs worldwide for 15+ years in stem cell research,
hES cells, embryonic development and human reproduction and IVF.
• Human IVF Laboratories that use our Coda ® Inline ® Filters have
reported better and more consistant overall pregnancy rates and
increases in live birth rates.
Coda ® Xtra Inline ® Filters – Small Investments – Big Savings
• Attaches to your incoming gas lines supplying cleaner gas due to an
increased amount of pure filtering materials, with an amplified residual
contact time and absorption capacity.
• Manufactured in a clean room environment with stringent quality
control.
• Delivered to you in an air tight sealed, sterilized packages.
• Economical and easy to install.
• Our Patented Technology makes Coda ® Filters a superior product and
is Patented Protected in the United States, European Union, Australia
and other countries worldwide. Coda ® Inline ® Filters are covered by the
following patents: U.S. Patent No. 6,013,119, No. 6,843,818, No.
6,225,110 and No. 6,200,362. The European Community Patent No: 98
923 448.9.
Be aware of counterfeit Inline ® Filters not safe for use in
Human IVF. You may introduce more contaminants as filters
may not be manufactured in a clean room environment and
filtering materials may not be cleaned, tested and properly
qualified for safe use in Human IVF.
N.S.
Grade 1
Day 7
Control
Coda
N.S.
Blasts
P < 0.05
Fresh
P < 0.05
Frozen
Day 8 Pregnant (Day 90+)
Effect of Coda Filtration on Bovine Embryo Qualuty and Pregancy Rates
(Merton et al., Theriogenology 67, 1233-1238, 2007)
FDA 510(k) Cleared

Voted #1 in IVF…
The Coda ® Canister is the only filter with a 97% efficiency rating.
With more activated carbon and potassium permanganate.
The Coda ® Canister has more absorption capacity and a longer life efficiency over all similar carbon, potassium
permanganate filled filters in the market today. The IVF laboratory requires the added protection of the Coda ® Canister
in your Coda ® Tower ECO TM , Coda ® Lo-Boy and HVAC systems.
The IVF Laboratory requires Better Air Quality…
By genX the “Leader in Air Purification” in IVF.
H
C
C
H
C
C
C
C
H
H
H
H
FDA 510(k) Cleared

The Coda ® Canister Main Stage Filter
The Coda ® Canister Main Stage Filter begins with a >95%
absorption efficiency rating which is far above the 57%
efficiency rating of conventional loose carbon filled V-cell
filters.
Installing the Coda ® Canisters, that come mounted on our
custom frame, will adsorb almost 1 lb of VOCs and CACs,
2 times that of a V-cell filter while still maintaining the same
efficiency rating.
Efficiency [%]
100.00
90.00
80.00
70.00
60.00
50.00
40.00
30.00
20.00
10.00
Single-Pass Molecular Filtration Efficiency of genX Coda Tower
and Lo-Boy Filters Gas-Phase challenge: 9 ppm toluene
2nd generation: 5 @ 10-in
gasketed canisters
1st generation: 12" x 24"
loose-fill v-cell filter
0.00
0 100 200 300 400 500 600 700 800 900 1000
Absorbed [g]
The Coda ® Canister will continually remove more harmful contaminants from the air in your IVF laboratory, without
a reduction in air exchanges, protecting you and your specimens.
The Coda ® Canister easily loads into the Coda Tower ® ECO TM , Coda ® Lo-Boy and most HVAC systems.
Coda ® Canister ECO TM
Coda ® Canister ECO TM Semi-Annual Kit Consists of:
• 4 Coda ® Canisters on frame
• 2 Coda ® PreFilters
Cat # GESA-001
Coda ® Canister ECO TM Annual Kit Consists of:
• 4 Coda ® Canisters on frame
• 1 Coda ® HEPA Filter
• 2 Coda ® PreFilters
Cat # GEAK-001
Coda ® Lo-Boy
Coda ® Lo-Boy Semi-Annual Kit Consists of:
• 5 Coda ® Canisters on frame
• 2 Coda ® PreFilters
Cat # CCLS-082
Coda ® Lo-Boy Annual Kit Consists of:
• 5 Coda ® Canisters on frame
• 1 Coda ® HEPA Filter
• 2 Coda ® PreFilters
Cat # CCLA-082

Coda ® Studies
(Racowsky et al., Proc. 11th World Congr. IVF & Hum. Reprod. Genet, 1999)
Lopez L, Rivero P, Llosá V, Palumbo A (2004) Fertilization, implantation, and pregnancy rates before and after the installation of
Coda ® incubator units in a human IVF laboratory. (unpublished). Centre de Fecundatión in Vitro Angela Palumbo (FIVAP), La
Laguna, Tenerife, Spain
Before
Coda ® Filters
With
Coda ® Filters
80
Period 6 months 12 months
Number of patients 65 154
60
Before Coda Filters
With Coda Filters
Patient age (years) 35.7 36.2
Number of cycles 86 207
Transfers: Day 2 1 68
Day 3 74 92
Day 4 0 3
Percent
40
20
58.5
74.8
13.1
21.7
27.6
41.3
Day 5 0 16
0
Fertilization Rate
Implantation Rate
Pregnancy Rate
Merton JS, Vermeulen ZL, Otter T, Mullaart E, de Ruigh L, Hasler
JF (2007) Carbon-activated gas filtration during in vitro culture
increased pregnancy rate following transfer of in vitro-produced
bovine embryos. Theriogenology 67, 1233-8.
% of Embryos or Transfers
50
40
30
20
10
0
N.S.
Control
Coda
Blastocysts
on Day 8
N.S.
Grade 1
Embryos
P < 0.05
Pregnancy
Rate
Mayer JF, Nehchiri F, Weedon VM, Jones EL, Kalin HL,
Oehninger SC, Toner JP, Gibbons WE, Muasher SJ (1999)
Prospective randomized crossover analysis of the impact
of an incubator air filtration system. Proc. 11th World
Congress on In-Vitro Fertilization and Human
Reproductive Genetics’
% of Transfers
Pregnancy Rate
P < 0.02
60
40
20
0
Control
Coda
PubMed link: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17331571

Coda Studies by Cohen et al.
Cohen J, Gilligan A, Esposito W, Schimmel T, Dale B (1997) Ambient air and its potential effects on conception in vitro.
Hum Reprod 12, 1742-9.
Schimmel T, Gilligan A, Garrisi GJ, Esposito Jr. B, Cecchi M, Dale B, Cohen J (1997) Removal of volatile organic
compounds from incubators used for gamete and embryo culture. Fertil Steril 68 Suppl. 1, S165 (Abstract P-151).
Cohen J, Gilligan A, Willadsen S (1998) Culture and quality control of embryos. Hum Reprod 13 Suppl 3, 137-44;
discussion 145-7.
Hall J, Gilligan A, Schimmel T, Cecchi M, Cohen J (1998) The origin, effects and control of air pollution in laboratories
used for human embryo culture. Hum Reprod 13 Suppl 4, 146-55.
Coda Studies by Others
Mayer JF, Nehchiri F, Weedon VM, Jones EL, Kalin HL, Oehninger SC, Toner JP, Gibbons WE, Muasher SJ (1999)
Prospective randomized analysis of the impact of an IVF incubator air filtration system (Coda, GenX) on clinical
pregnancy rates. In 'Proc. 11th World Congress on In-Vitro Fertilization and Human Reproductive Genetics’ pp. P-
096
Mayer JF, Nehchiri F, Weedon VM, Jones EL, Kalin HL, Oehninger SC, Toner JP, Gibbons WE, Muasher SJ (1999)
Prospective randomized crossover analysis of the impact of an IVF incubator air filtration svstem (Coda. genX) on
clinical pregnancy rates. Fertil Steril 72, Suppl 1, S42 (Abstract O-110).
McLellan ST, Panagoulopoulos C, Dickinson KA, Wright DL, Toth TL, Lanzendorf SE (2001) Effect of incubator air
filtration system on IVF outcomes. Fertil. Steril. 76, Suppl.1, S103.
Merton JS, Vermeulen ZL, Otter T, Mullaart E, de Ruigh L, Hasler JF (2007) Carbon-activated gas filtration during in
vitro culture increased pregnancy rate following transfer of in vitro-produced bovine embryos. Theriogenology 67,
1233-8.
Racowsky C, Jackson KV, Nurredin A, Balint C, Shen S, de los Santos MJ, Kely JR, Pan Y (1999) Carbon-activated
air filtration results in reduced spontaneous abortion rates following IVF. In ‘Proc. 11th World Congress on In-Vitro
Fertilization and Human Reproductive Genetics’. Sydney, Australia. (Ed. .) pp. O-059 (Abstract)
Battaglia DE, Khabani A, Rainer C, Moore DE (2001) Prospective randomized trial of incubator Coda filtration units
revealed no effect on outcome parameters for IVF. Fertil. Steril. 75 Suppl.1, S6.
Forman M, Polanski V, Horvath P, Gilligan A, Rieger D (2004) Reductions in volatile organic compounds, aldehydes,
and particulate air contaminants in an IVF laboratory by centralized and stand-alone air filtration systems. Fertility
and Sterility 82 Suppl. 2, S324 (Abstract P535).
Lopez L, Rivero P, Llosá V, Palumbo A (2004) Fertilization, implantation, and pregnancy rates before and after the
installation of Coda® incubator units in a human IVF laboratory. Unpublished.
sales@IVFonline.com
www.IVFonline.com
US/Canada: 1-800-720-6375
Intl.: 1-519-826-5800
Fax: 1-519-826-6947

The original Coda Tower ® has been redesigned to SAVE ENERGY
and to HELP our environment, giving you the new Coda Tower ®
ECO TM .
The ECO TM has a smaller footprint, using less laboratory space, while
increasing air flow, CFM’s and air exchanges, changing the air in your laboratory
more times per minute. More air exchanges means cleaner air.
Our Coda ® Canister filters remove and reduce the levels of VOCs, (volatile organic
contaminants) and CACs (chemical air contaminants) while our 99.997% HEPA
filter removes far more particulates due to the increased air exchanges.
Benefits of the Coda ® Tower ECO TM
ECO-friendly ECO-nomical ECO-filter pack
ISO13485:2003 and ISO9001:2000 Company
FDA 510(k) Cleared
US/Canada: 1-800-720-6375
International: 1-519-826-5800
Fax: 1-519-826-6947
email: sales@IVFonline.com
©2010 international G-CODAFOLD-2010-03-16