Introduction to bioinformatics - National Genetics Reference ...

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Major Bioinformatics Databases • Growing steadily in number and in size – In Nucleic Acids Research journal, they reported 179 databases, 95 were new – In total there are 1170 molecular biology databases • Specialisations – Which genome they contain (mouse, human, all of them) – Which types of information about the genome they contain • Contain information such as – Sequences: of bases and of residues – Structure: 3d conformations of known proteins – Families: Which sets of genes are known to be homologous – Annotations: which processes each gene is involved in • And lots of other information – Conceptual structure • How concepts in biology/genetics are related to each other • Here is a list of some of the different ones
Primary sequence resources Nucleic EMBL GenBank DDBJ Protein SWISSPROT TrEMBL PIR NRL-3D •They have long-term national or international funding •The resources are: – Archival: they take the data as produced with little or no addition of information – Horizontal: they gather all of a type of information from all sources
Page 1 and 2: Shedding some light on Bioinformati
Page 3 and 4: What is Bioinformatics? “Bioinfor
Page 5: GENE EXPRESSION ANALYSIS COMPARATIV
Page 8 and 9: Growth of Sequences and Annotations
Page 10 and 11: Computers - they are your workbench
Page 12 and 13: Computer Software On a computer the
Page 16 and 17: Nucleic Acid Sequence Databases •
Page 18 and 19: Issue 1: Why so many IDs? Biology!
Page 20 and 21: Issue 3: Data redundancy COMMENT RE
Page 22 and 23: CDS 133..4575 Database entries usua
Page 24 and 25: FEATURES Location/Qualifiers source
Page 26 and 27: NCBI Map of links between Entrez no
Page 28 and 29: An accession number and identifer N
Page 30: Issue 5 cntd. • Most databases st
Page 34: Issue 6 cntd: : Standard vocabulary
Page 37 and 38: Issue 7: sequence formats - how man
Page 39 and 40: Multiple FASTA sequences in one fil
Page 41: Sequence Retrieval System (SRS) •
Page 44 and 45: Issue 8: Keeping up-to to-date with
Page 46 and 47: Issue 10: Data Security and Clinica
Page 48: We all are bioinformaticians! “Bi

Introduction to bioinformatics - National Genetics Reference ...

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