Introduction to bioinformatics - National Genetics Reference ...
Introduction to bioinformatics - National Genetics Reference ...
Introduction to bioinformatics - National Genetics Reference ...
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Issue 5: Annotation quality for biological<br />
databases<br />
• Annotation is additional information <strong>to</strong> the raw<br />
sequence; for example, references, gene position,<br />
cross – links <strong>to</strong> other databases<br />
• Most genes/proteins are identified and annotated<br />
based on the similarity <strong>to</strong> other genes with known<br />
functions using au<strong>to</strong>mated <strong>bioinformatics</strong> <strong>to</strong>ols<br />
(pipeline)<br />
• Comparison was made when data was less complete<br />
• If sequence is incorrectly annotated, the error<br />
propagates in the database
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