The PiTT-CMU MSTP NewSleTTer - University of Pittsburgh :: MSTP

The PiTT-CMU MSTP NewSleTTer
University of Pittsburgh | Carnegie Mellon
Volume IX, No. 1
Fall 2010
Contents
2010 MSTP
Retreat, 1, 4
Alumni Profile:
David Levinthal
(‘06), 2-3
Director’s Corner,
3
Grand
Introductions: The
Incoming Class of
2010, 5
Newly Funded
Fellowships and
Recently Awarded
PhDs, 6
2010 MSTP Annual Retreat
MSTP students, faculty, alumni, and program adminstrators convened for some
great science, fun and relaxation, and quality peer mentorship
The 14th annual retreat of the University of
Pittsburgh-Carnegie Mellon University MSTP
was held on August 20-22, 2010. The retreat
commenced on Friday, August 20th in the
Biomedical Science Tower (BST) at the University
of Pittsburgh with an illuminating talk by the
Friday keynote speaker, Laura Niedernhofer,
MD, PhD, Associate Professor of Microbiology
and Molecular Genetics. Dr. Niederhofer spoke
about her research on the process of aging, while
touching upon her career path, her selection of
mentors, and the maturation of her scientific
interests. The keynote speech was followed
by two student scientific talks (meanwhile, the
director of the MSTP, Clayton Wiley, MD, PhD,
gave an update on the MSTP to affiliated faculty).
Aaron Secrest (MS3) presented first, detailing his
graduate studies in epidemiology with a talk titled
“Mortality in Childhood-Onset Type I Diabetes is
Improving”). Following Aaron’s talk, Sam Clanton
(G6) featured his work in the CMU Robotics
graduate program with a presentation titled
“Simultaneous 7-Dimensional Cortical Control
of an Arm and Hand Robot via Direct Brain
Interface.” Next, James Bales (MS3), Yvonne
Chao (G4), and Vineet Agrawal (G3) gave a
presentation about their recent experience at the
2010 American Physician Scientist Association
national conference. Following the talks, 76
students from the Pitt-CMU MSTP took over
the first floor lobby of the BST to present their
research in written abstract and poster formats to
colleagues and faculty. After the poster session
and lunch, the presentations for the William
E. Brown Outstanding Mentor Award and the
Drs. S. Sutton Hamilton MSTP Scholar Award
were given. Satdarshan Pal Singh Monga,
MD, thesis advisor to MSTP student Michael
Thompson (MS3), was awarded the Outstanding
Mentor Award, and Corrine Kliment (MS4)
was awarded the MSTP Scholar Award for her
outstanding scientific contributions in Dr. Tim
Oury’s laboratory. After a group photograph was
taken within the voluminous foyer of the Petersen
Events Center, the retreat attendees dispersed
for the drive to Seven Springs Mountain resort.
The Seven Springs portion of the retreat
began Friday evening with an indoor/outdoor
barbeque, followed by a friendly team-building
competition. Highlights of the team-building
activities included trivia, a faculty-themed variant
of “pin the tail on the donkey,” MSTP-themed
charades, and a Rock Band finale. Later in
see page 4, Retreat
Student
Announcements, 6
Student
Publications, 7
Upcoming Events,
8
Above: The students and staff of the Pitt-CMU MSTP, August 2010. (Photo credit: University of Pittsburgh
CIDDE) Right top: Corrine Kliment (MS4), winner of the 2010 Drs. S. Sutton Hamilton MSTP
Scholar Award (Photo credit: Judd Englert, MS4) Right bottom: Michael Thompson (MS3, left) with
his thesis mentor and winner of the William E. Brown Outstanding Mentor Award , Dr. Satdarshan
Monga (right) after Michael’s defense. (Photo courtesy of Michael Thompson)
1

Profiles in Medicine: David Levinthal
An alumnus from the Class of 2006 explores the decisions that shaped his path from undergraduate
studies at Cornell University to the Pitt-CMU MSTP and his current fellowship in GI.
2
Dr. David Levinthal graduated from
the Pitt MSTP in 2006. Accepted into the
University of Michigan’s gastroenterology
fast-track program, he completed two
years of Internal Medicine Residency
in Ann Arbor, before returning to Pitt to
pursue a post-doctoral year of research
with Dr. Peter Strick in the Department of
Neurobiology. Dr. Levinthal continued to
do full-time research with Dr. Strick during
the first year of his GI Fellowship and is
now entering his second fellowship year.
Below, he shares his candid thoughts
on his career path and advice for future
physician-scientists.
Q: How did you decide on a career as
an MD-PhD?
A: I have known from an early age that I
wanted to pursue a career in the sciences.
That interest became more specifically
targeted to neuroscience by the time I
completed college and began medical
school. I had a tremendous research
experience in my undergraduate lab at
Cornell University, working on vitamin A
metabolism, intracellular trafficking, and
nuclear receptor interaction. Although this
experience prepared me well for the reality
and frustrations of laboratory science, I
loved it and was hooked. In retrospect,
I realize that my mentor gave me a lot of
responsibility and an actual, publishable
project – my data ended up in a JBC
publication! I had a solid two years with
that group, and I felt a bit like a graduate
student by the end. After that experience,
there was no question in my mind that I
wanted to be a scientist.
Cornell has a very strong premed
curriculum and I had a few good
experiences shadowing physicians, as
well as doing a hospital-based research
project, but I wasn’t sure I wanted to
pursue medicine at first. I thought I had to
make a choice, and although I really liked
the idea of being a physician, I would have
pursued a PhD program if I’d been forced
to decide between the two.
Then I learned about MD/PhD
programs. What a perfect fit! You can do
BOTH? What a cool way to synthesize
patient care, basic science, and the
potential for translational research. When
the time came to apply to medical school,
I applied to mostly MD/PhD programs.
Q: How did you pick your thesis lab
and mentor?
A: I think the main drives for choosing
my thesis lab were: 1) to actually like my
mentor as a person (and potential friend)
2) finding a mentor with a good reputation
as a advisor/teacher, and 3) being
presented with a clear idea about my
research project from the very beginning.
I interviewed with many advisors, but
ultimately when I met Don DeFranco we
just clicked. He had a great idea for a
research project dealing with oxidative
stress and cell death in neurons, and so I
signed on. I think it’s really important that a
thesis project have discernable research
goals and publishable experimental units
that are designed to answer a question no
matter what the result. Dr. DeFranco had
a clear sense of my thesis project pretty
much from the start, and he laid it all out
when we first met. I decided to join the lab
because the project appeared interesting
and feasible. We applied for an F-30 and
it was funded in the first round of review,
largely because he had already put a lot
of thought into the project before we even
got started. That helped me get through
my PhD in a timely manner (3.5 years)
even with the anticipated research snags
and inevitable technical problems.
Q: How did you choose your specialty?
A: Like most medical students, I didn’t
know which direction I was going in
until sometime during third year. By the
time I’d nearly finished graduate school,
I had developed an interest in pain
research, so I thought about how best to
pursue that – anesthesiology? neurology?
internal medicine? After I started third
year rotations, it became clear to me that
internal medicine really was the best fit.
Then I had to come up with a specialty.
So I did rotations in gastroenterology,
endocrine, and critical care. After reflecting
and speaking with faculty, I realized that
my interests were directed toward a
procedure-based specialty that required
a broad scope of medical knowledge. For
me, that specialty was gastroenterology.
GI deals with multiple organs, complex
physiology, manifestations of disease
secondary to systemic illness, among other
things – in total, a complex and varied field.
Perfect for me. Then how does GI relate to
neuroscience? Well one of the fascinating
aspects of GI is the mind-body connection
that likely plays a role in functional bowel
disorders. While intuitively connected, the
neurophysiologic basis of CNS control
over GI function is poorly understood.
As you may imagine, there are not many
neuro-gastroenterologists, so my interest
in neuroscience seemed like a natural fit
to fill this gap in knowledge. In addition,
from a funding standpoint, it’s always a
good thing to study an incredibly prevalent
disease, and to be uniquely trained to do
so.
Q: Can you tell me what a typical day
for you right now is like?
A: Right now, my days are spent on
inpatient consults, performing procedures,
and spending half a day a week in
continuity clinic. I’m on-call once every
eight to nine days, and during that time,
I cover the VA, Magee, and Montefiore/
Presby. It can get very busy. Our fellowship
program has an impressive educational
component with lectures/conferences
throughout the week, typically starting
at 7:30 a.m. So a typical day could be:
conference from 7:30-8:30 a.m., see
follow-up patients in the hospital, get new
consults, do some procedures, finish
see page 3, Levinthal

On June 1, 2010 we matriculated
a new class of 14 students (13 new
students in addition to one internal
second year medical student). As in
past years, the new students hail from
outstanding undergraduate schools
where they excelled in both academics
and research. With an average GPA of
3.73 and an average MCAT of ~35 they
demonstrate the continued success of
our MSTP to matriculate the best and the
brightest. All of the first years completed
their first professional development
course (molecular medicine) in addition
to a lab rotation from which they compiled
their Retreat posters.
For the rising second year
students, this was the inaugural year of
the summer professional development ii
course (methods and analysis) taught by
Dr. Geoff Murdoch and myself. In addition
to learning about their classmates’
summer research, the students were
given ample opportunity to formally
present their data and begin to create
their “elevator spiel” for use in future
networking. To keep them “off their toes,”
the students sampled a variety of red
wines throughout the course and then
were rigorously grilled in a blind tasting.
Only one student correctly matched all
the wines to grapes, so while Neil Kelly
has a potential additional career as a
sommelier, the rest will have
to buckle down to science
and medicine.
This fall begins our
MSTP workshops, a yearlong
series of eight discussions
over dinner. These workshops
are designed to maximize interactions
between students across different
stages of training. Groups of eight
students (one student from each class)
will analyze research, training, medical
and ethical cases germane to the
training of all physician scientists. Each
class, in turn, will have the opportunity
to contribute to the case discussed,
Director’s Corner
A Message From Clayton Wiley, MD, PhD
Associate Dean, Director of MSTP
lead the discussion at their respective
tables, and to summarize the outcome
of the dinner discussion and potentially
present it in a written form such as in
future newsletters. Like all other aspects
of our MSTP, the workshops are an
experiment and represent our continued
efforts to push the edge of the envelope
in training physician scientists.
from page 2, Levinthal
documentation, go home by about 6:30-7
p.m. Repeat.
But the past two years I was doing
100 percent research during a post-doc
period of training built into my fast-track
pathway in GI. The fast-track is a relatively
new training path in internal medicine
designed for MD/PhDs who have a very
good sense of what specialty they wish to
pursue. For GI, the pathway is two years
residency plus four years fellowship (two
and a half years of which can be spent
doing research).
Q: How do you balance family time
and career or how do you see yourself
balancing these in the future?
A: My wife, Sarah, and I have found a
balance that works for us. It was really
hard to have quality time with her during
my internship – I was a walking zombie for
most of the year. But she was so wonderful
and supportive – I don’t think I could have
made it through it without her. The best
advice is to really make the most of the time
you have with your family. We tend to plan
little day trips or outings for my days off.
That makes them memorable and special.
Our son was born last August
and I was very fortunate to have a flexible
schedule last year. Now it’s much harder
that I’m back in the clinic full-time. Again,
the days off are precious and my first
priority is to spend time with the family.
There is no question that pursuing a
medical career puts a strain on family life.
But the silver lining is that an academic
medicine career, once well established,
may present some opportunities for a
more flexible schedule. Someday. Maybe.
Q: Where do you see yourself in ten
years?
A: By then I will certainly be on the faculty
somewhere, likely here at the University
of Pittsburgh if all works out. I hope to
have my second R01 grant by then and
have made it to the rank of associate
professor with a successful tenure. My
ideal balance would be to have about 80
percent of my time devoted to research
with 20 percent clinical effort. I’d also like
to be involved in national GI organizations
like the AGA by serving on committees,
as well as beginning to be invited to give
presentations at outside institutions. I’d
also like to have an independent lab, with
graduate students, post-docs, and possibly
fellows working with me. The coolest thing
would be to begin to translate some of my
research into actual therapeutic trials. A tall
order, but one can dream.
Q: What advice do you have for current
MSTP students?
A: ASK QUESTIONS! Navigating this
career path is very difficult. It is easy to
lose time. Before making any of the major
decisions, ask lots and lots of questions
– of the alumni, of students further
along in the program, of PhD program
students, post-docs, everyone. Don’t
forget about your original class of medical
students that went straight through to
residency. They are seasoned, veteran
residents/fellows, maybe even attending
physicians, by the time you are applying
to residency programs. Their input is
invaluable because they are your friends
and they’ll give you the honest truth about
specific residencies and career paths.
Q: Final thoughts?
A: I couldn’t have made a better decision
for my career. Every year that goes by, I
love practicing medicine more and more.
It becomes a part of your self-image and
at this point, after being involved in patient
care to some degree since 1998, it’s pretty
hard-wired into me. Of course, research
has always been something that I have
loved from the start.
Interview conducted by Niyathi Hegde
(G1)
Alunni Relations Chair
Dr. David Levinthal can be reached at
dlevinth@pitt.edu
3

from page 1, Retreat
the evening, there was free time and
students enjoyed a poker tournament,
various jam sessions, and the Rock Band
video game. At the end of the evening,
David Wheeler (G3)led the incoming
MSTP students on the traditional hike to
the top of the Seven Springs mountain.
Saturday morning started
off with the classic Seven Springs
hearty breakfast buffet followed by
the “State of the Program” address
given by Dr. Clayton Wiley. Dr. Wiley
introduced the newest members of
the MSTP before discussing issues
ranging from medical school reentry to
USMLE Step 1 board exam changes.
Following Dr. Wiley’s address,
graduating MS4 students imparted
pearls of wisdom garnered through
their years of training in PowerPoint
form. This year junior students listened
to insightful presentations by Mandar
Aras, Mehret Birru, Frank Cackowski,
Judd Englert, Melanie Ruffner, Corrine
Kliment, Jeremy Tilstra, Pete Vosler, and
Genevieve Woodard. Retreat attendees
were also honored to hear a presentation
on alternative career options for MSTP
graduates by Pedram Afshar, MD, PhD,
who graduated from the Pitt-CMU MSTP
in 2009.
This year, four workshops were
prepared for the Saturday afternoon
session instead of the traditional three
to address the interests of students at
all different levels of training. For the
incoming first years, MSTP co-directors
Richard Steinman, MD, PhD, and
George Stetten, MD, PhD, introduced
the scientific community in Pittsburgh
and discussed using scientific resources
here to advance a translational research
agenda. Second year students were
treated to a presentation covering study
tips for their upcoming USMLE Step
1 board exam later in the school year.
For junior graduate students, Michelle
Kienholz, a professional science writereditor
at the University of Pittsburgh,
spoke about communication in science
through manuscripts, oral presentations,
and other avenues. For senior graduate
students, Dr. Wiley and alumnus Brian
Shirts, MD, PhD (Class of 2006) gave
a presentation about interviewing for
residency, a departure from previous
years in which the topic was negotiating
your first job after residency. Following
the workshops, students were able to
relax and enjoy the resort’s various
outdoor recreational activities, including
volleyball, swimming, tennis, and bicycling
(organized by Mike Leibowitz, G5).
Evening brought along a candlelit
dinner featuring the entrees New
York Strip Steak, Broiled Crabcakes,
and Eggplant Tower. The Saturday
night keynote speaker was alumnus
Robert Labadie, MD, PhD (Class
of 1996), Associate Professor of
Otolaryngology-Head and Neck Surgery
& Bioengineering from Vanderbilt
University. He spoke about his career
trajectory and research while pausing
to offer various “pearls” of wisdom
along the way regarding successfully
navigating a career as a physician
scientist. Following the completion of
official activities, students enjoyed an
evening of social activities, including
another jam session. On Sunday, many
students opted to participate in the
MSTP-sponsored golf and whitewater
rafting outings (organized by Gaurav
Shukla (G5) and Dani Simmonds (G1),
respectively).
by John Kang (G2)
2010 Retreat Co-chair
4
Above Top Left: Dr. Laura Niedernhofer talks about her career path and current research program at the Keynote Address. (Photo credit: David Svilar, G3) Above Top Middle:
Jeff Koenitzer (G3), Maxx Horowitz (G4) and Daniel Roh (G4) raise the roof with their jazzy tune. (Photo credit: Liang-I Kang, G3) Above Top Right: MSTP students present their
latest data to their peers and to faculty at the poster sessions on Friday. (Photo credit: David Svilar) Above left: During the Friday night team-building activities, a blindfoleded
Dr. Clayton Wiley cautiously attempts to “pin the glasses on the Murdoch” using only his teammates’ shouted insrtuctions to guide him. (Photo credit: Liang-I Kang) Above Right:
MS1s and accompanying upperclassmen stand triumphantly on the peak of the ski slope after the notoriously symbolic hike. (Photo credit: Liang-I Kang)

Grand Introductions: the incoming
Class of 2010
THE BAD (as in good) BOYS
Up first…Matthew Hedberg: Matt hails from the University of
Utah. He is interested in the BMG graduate program. Mr. Hedberg
enjoys going out (agoraphobics have less fun), watching movies,
and going to concerts. In a single word, his entire essence can be
summed up as cogent. I suppose he convinced the right people to
let him join our ranks.
Runner up…Benjamin Rothrauff: Ben attended Northwestern
University. He plans to join the bioengineering program. In his
free time Ben likes exercising, learning biomechanics, and reading.
Fortunately he can exercise his brain while reading about biomechanics
to maximize his time. Mr. Rothrauff can be described
as simply urbane, bringing class and sophistication to the city of
Pittsburgh.
Third, but not third-rate…Brian Ahn: Brian joins us from
the University of California, Berkeley. Just like our other Brian
(Rosborough), he will be joining the immunology graduate program.
For fun, Mr. Ahn enjoys outdoor activities like rock climbing
and hiking as well as playing guitar and anything physical. Guys
that are musically, mentally, and physically gifted can only be described
as versatile.
Connect Four…Xuan Ding: Mr. Ding will ring your bell. Joining us
from Duke University, he plans to study bioengineering/biomedical
engineering. In his spare time, he plays basketball, watches
TV, and participates in outdoor activities. Like most scientists, he
considers himself to be a pragmatist.
Favorite (#) Five…Bo Wang: Bo is anything but Bo-ring. He likes
to split his time among school, soccer, Starcraft II, and badminton.
Mr. Wang is going into the bioengineering program. He went to
the University of Pittsburgh for his undergraduate degree and is
staying with us. Bo describes himself as a meanderer, but faithful
seems more fitting.
Sizzling Six…Daniel Chung: Dan went to Johns Hopkins University
for undergrad and is looking forward to joining CNUP for
graduate education. Like his fellow first-year Bo, he enjoys Starcraft
in addition to most video games and watching movies. Don’t
be fooled--Daniel is no couch potato, but describes himself plainly
as moderate.
The Flavorful First Year…Matthew Geramita: Coming from the
University of Michigan, Matt is planning on joining the neuroscience
graduate program. Mr. Geramita enjoys running, grilling, and
exploring used book stores. As a grill king, Matt’s fundamental nature
can only be described as hickory-smoked.
Knock. Knock. Who’s there?…Jared Moreines: Joining us from
the South, Jared attended Emory University. This Southern gentleman
is planning to join the neuroscience graduate program. Mr.
Moreines enjoys cooking, skiing, and tennis. In addition to his skills
inside and outside of the kitchen, Jared is humorous. Who knew
we had a jokester on our hands?
Last but not least…James (Randall) McAuley: Randall, like his
fellow first-year Bo, just can’t get enough of Pennsylvania. He attended
Swarthmore College and is keeping an open mind about
graduate programs at Pitt. Mr. McCauley likes to fence, hike, and
play the cello. With his courtly ways, he’ll be playing our heart
strings in no time.
THE PHENOMENAL FEMALES
Numero Uno…Adrienne Taren: Adrienne graduated from
Middlebury College in 2009. She plans to study neuroscience/psychology
at CMU during her graduate school years.
She enjoys biking, running, and dancing. As a true physical
activity enthusiast, she can be described as enigmatic.
Dueces wild…Beth Oczypok: Beth is joining the ranks of
our fellow “Pittsburgh lifers,” hailing from the University of
Pittsburgh. She’s looking forward to joining the BMG program.
Beth enjoys reading, baking, and traveling. Perhaps
her nurturing persona will score us some baked goods at the
monthly MSTP workshops.
Triple threat…Julie Boiko: Julie excels on land, water, and
air! Joining us from Stanford University, Julie has landed herself
in the first year MSTP class. She enjoys swimming and
traveling, and describes herself as aquatic. However, she
plans to join the immunology program (a rather dry field).
Julie also enjoys reading about theology in her spare time.
Fantastic Four…Rachael Gordon: Rachael attended the
University of Pennsylvania for undergraduate education.
She plans to join the immunology graduate program here
at Pitt. Beware! Miss Gordon practices martial arts, so you
don’t want to come across her path in a dark alley. She also
enjoys cooking and home-brewing. Just like a bittersweet
beer, Rachael can be described as hoppy.
(Note: Rank according to order of email response.)
by Natasha Corbitt (G2)
2010-2011 Peer Mentorship/Welcoming Chair
Above: (back row, left to right) Matthew Geramita, Jared
Moreines, Matthew Hedberg, Benjamin Rothrauff, (front row, left
to right) Brian Ahn, Xuan Ding, J. Randall McAuley, Julie Boiko,
Elizabeth Oczypok, Adrienne Taren, Bo Wang, D. Wonjae Chung,
Rachael Gordon (Photo credit: University of Pittsburgh CIDDE)
5

Student Accolades
Congratulations to our newly funded Fellowships!
Vineet Agrawal
ECM Degradation and Macrophage Polarization in
Endogenous Stem Cell Recruitment (F30, Mentor:
Stephen Badylak, MD, PhD)
Natasha Corbitt
The Role of Gut Bacteria in Kupffer Cell Developmental
and Function (F31, Mentor: A. Jake Demetris,
MD)
Gil Hoftman
Developmental Trajectories of Prefrontal Cortical
GABA Neurons and Schizophrenia (F30, Mentor:
David Lewis, MD)
Max Horowitz
GATA2 as a Therapeutic Target in Parkinson’s Disease
(F30, Mentor: J. Timothy Greenamyre, MD,
PhD)
Benjamin Mantell
Metabolic Crosstalk Between Cells and the Liver in
Obesity (F30, Mentor: Robert O’Doherty, PhD)
Jason Sanders
Epidemiology of Lens Aging in Older Women (F30,
Mentor: Anne Newman, MD, MPH)
Congratulations, Doctor! Recently Awarded PhDs
James Bales
Dopamine and Camp Regulated Phosphoprotein, 32 KDA: A novel therapeutic target in traumatic brain injury,
Advisor: Edward Dixon, PhD (Neuroscience, Pitt)
Christin Glorioso
Between Destiny and Disease: Genetics and Molecular Pathways of Human Central Nervous System Aging,
Advisor: Etienne Sibille, PhD (Neuroscience, Pitt)
Carl Johnson
Preclinical Biocompatibility Assessment of Pediatric Ventricular Assist Devices, Advisor: William Wagner, PhD
(Bioengineering, Pitt)
Gerald Nora
Processing of Alternative DNA Structures in the Human Telomere, Advisor: Patricia Opresko, PhD (Molecular
Biophysics/Structural Biology, Pitt)
Aaron Secrest
Mortality Trends in a Population-based Type 1 Diabetes Cohort, Advisor: Trevor Orchard, MBBCh, MMedSci
(Epidemiology, Pitt)
Michael Thompson
β-cantenin: A friend or foe in liver pathobiology, Advisor: Satdarshan Monga, MD (Cellular & Molecular
Pathology, Pitt)
Student Announcements
6
David Wheeler (G3) and Amir Faraji (G4) attended the 2010
Nobel Laureate Meeting at Lindau (Germany) from June 27-
July 2, 2010. Amir was sponsored by the NIH and David was
sponsored by the Oak Ridge Associated Universities (ORAU).
Lola Grace Grimm Secrest (6 lb
11 oz, 19.5 inches) was born to
Aaron (MS3) and Katie Secrest
on June 26, 2010.

New MSTP Student Publications through September 2010
Kaczorowski, D.J., Afrazi, A., Scott, M.J., Kwak, J.H., Gill, R., Edmonds, R.D., Liu, Y.,
Fan, J., and T.R. Billiar. (2010). Pivotal Advance: The pattern recognition receptor
ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor
B synthesis by the macrophage through distinct but overlapping mechanisms. J
Leukoc Biol.Oct; 88(4):609-18. [PMID: 20413727]
Richardson, W.M., Sodhi, C.P., Russo, A., Siggers, R.H., Afrazi, A., Gribar, S.C.,
Neal, M.D., Dai, S., Prindle, T. Jr, Branca, M., Ma, C., Ozolek, J., Hackam DJ.
(2010). Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4
signaling in the intestinal epithelium. Gastroenterology. Sep; 139(3):904-17, 917.
e1-6. [PMID: 20580721]
Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W., and C.E. Dixon. (2010). Alterations in
calcineurin subunit B isoform expression in rat hippocampus following a traumatic
brain injury. Brain Res. Oct 28; 1358:211-20. [PMID: 20713027]
Bridges, J.P., Ikegami, M., Brilli, L.L., Chen, X., Mason, R.J., and J.M. Shannon.
(2010). LPCAT1 regulates surfactant phospholipid synthesis and is required
for transitioning to air breathing in mice. J. Clin. Invest. May 3; 120(5):1736-48.
[PMID: 20407208]
Chan, V., Starr, P.A., and R.S. Turner. (2010). Bursts and oscillations as independent
properties of neural activity in the parkinsonian globus pallidus internus. Neurobiol.
Dis. Aug 18 [Epub ahead of print; PMID: 20727974]
Chao, Y.*, Shepard, C.R.*, and A. Wells. (2010). Breast carcinoma cells re-express
E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer. Jul
7; 9(1):179. [PMID: 20609236]
Rajagopalan, M.S., Stone, B., Rwigema, J.C., Salimi, U., Epperly M.W., Goff, J.,
Franicola, D., Dixon, T., Cao, S., Zhang, X., Buchholz, B.M., Bauer, A.J., Choi,
S., Bakkenist, C., Wang, H., and J.S. Greenberger. (2010). Intraesophageal
Manganese Superoxide Dismutase-Plasmid Liposomes Ameliorates Novel Total-
Body and Thoracic Radiation Sensitivity of NOS1(-/-) Mice. Radiat Res. Sep;
174(3):297-312. [PMID: 20726721]
White, J.S., Choi, S., and C.J. Bakkenist. (2010). Transient ATM kinase inhibition
disrupts DNA damage induced sister chromatid exchange. Sci Signal. Jun 1;
3(124):ra44. [PMID: 20516478]
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Divito, S.J., Wang, Z., Shufesky, W.J., Liu, Q, Tkacheva, O.A., Montecalvo, A., Erdos,
G., Larregina, A.T., and A.E.Morelli. (2010). Endogenous dendritic cells mediate
the effects of intravenously injected therapeutic immunosuppressive dendritic cells
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Divito, S.J. and L.K. Ferris. (2010). Advances and short-comings in the early detection
of melanoma. Melanoma Res. Dec; 20(6):450-8. [PMID: 20856147]
Marenco, S., Savostyanova, A., van der Veen, J.W., Geramita, M., Stern, A., Barnett,
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Glorioso, C., Oh, S., Duillard, G. and E. Sibille. (2010). Brain molecular aging, promotion
of neurological disease and modulation by Sirtuin5 longevity gene polymorphism.
Neurobiol Dis. Sep 29. [Epub ahead of print; PMID: 20887790]
Wang, L, Gordon, R.A., Huynh, L., Su, X., Park Min, K.H., Han, J., Arthur, J.S., Kalliolias,
G.D., and L.B. Ivashkiv. (2010). Indirect inhibition of Toll-like receptor and
type I interferon responses by ITAM-coupled receptors and integrins. Immunity.
Apr 23; 32(4):518-30. [PMID: 20362473]
Gupta, A.S., van der Meer, M.A.A., Touretzky, D.S., and A.D. Redish. (2010). Hippocampal
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Haldar, M., Hedberg, M.L., Hockin, M.F., and M.R. Capecchi. (2009). A CreER based
random induction strategy for modeling translocation-associated sarcomas in mice.
Cancer Res. Apr 15; 69 (8):3657-64. [PMID: 19351831]
Marcu, J.P., Christian, R.T., Lau, D., Zielinski, A.J., Horowitz, M.P., Lee, J., Pakdel, A.,
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on human glioblastoma cell proliferation and survival. Mol Cancer Ther. Jan;
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Horowitz, M.P. and J.T. Greenamyre. (2010). Mitochondrial iron metabolism and
its role in neurodegeneration. J Alzheimer’s Dis. 20 Suppl. 2: S551-68. [PMID:
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Horowitz, M.P. and J.T. Greenamyre. (2010). Gene-environment interactions in Parkinson’s
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Bosch, J.J., Iheagwara, U.K., Reid, S., Srivastava, M.K., Wolf, J., Lotem, M., Ksander,
B.R., and S. Ostrand-Rosenberg. (2010). Uveal melanoma cell-based vaccines
express MHC II molecules that traffic via the endocytic and secretory pathways
and activate CD8(+) cytotoxic, tumor-specific T cells. Cancer Immunol Immunother.
Jan; 59(1):103-12. [PMID: 19557412]
Johnson, C.A. Jr., Vandenberghe, S., Daly, A.R., Woolley, J.R., Snyder, S.T., Verkaik,
J.E., Ye, S.H., Borovetz, H.S., Antaki, J.F., Wearden, P.D., Kameneva, M.V., and
W.R. Wagner. (2010). Biocompatibility assessment of the first generation Pedia-
FlowTM Pediatric Ventricular Assist Device. Artif Organs. Jul 9 [Epub ahead of
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Ye, S.Ho., Johnson, C.A. Jr., Woolley, J.R., Murata, H., Gamble, L.J., Ihsihara, K., and
W.R. Wagner. (2010). Simple surface modification of a titanium alloy with silanated
zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity.
Colloids Surf B Biointerfaces. Sep 1; 79(2):357-64. [PMID: 20547042]
Zhong, Z., Chang, S.A., Kalinowski, A., Wilson, K.L., and K.N. Dahl. (2010). Stabilization
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Dahl, K.N., Kalinowski, A., and K. Pekkan. (2010). Mechanobiology and the microcirculation:
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Kliment, C.R., and T.D. Oury. (2010). Oxidative stress, extracellular matrix targets,
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Houghton, A.M., Rzymkiewicz, D.M., Ji, H., Gregory, A.D., Egea, E.E., Metz, H.E.,
Stolz, D.B., Land, S.R., Marconcini, L.A., Kliment, C.R., Jenkins, K.M., Beaulieu,
K.A., Mouded, M., Frank, S.J., Wong, K.K., and S.D. Shapiro. (2010). Neutrophil
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Koenitzer, J.R., and B.A. Freeman. (2010). Redox signaling in inflammation: interactions
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Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B.,
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Tottey, S., Corselli, M., Jeffries, E.M., Londono, R., Peault, B., and S.F. Badylak. (2010).
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7

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The University of Pittsburgh and Carnegie
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