Student Accolades Congratulations to our newly funded Fellowships! Vineet Agrawal ECM Degradation and Macrophage Polarization in Endogenous Stem Cell Recruitment (F30, Mentor: Stephen Badylak, MD, PhD) Natasha Corbitt <strong>The</strong> Role <strong>of</strong> Gut Bacteria in Kupffer Cell Developmental and Function (F31, Mentor: A. Jake Demetris, MD) Gil H<strong>of</strong>tman Developmental Trajectories <strong>of</strong> Prefrontal Cortical GABA Neurons and Schizophrenia (F30, Mentor: David Lewis, MD) Max Horowitz GATA2 as a <strong>The</strong>rapeutic Target in Parkinson’s Disease (F30, Mentor: J. Timothy Greenamyre, MD, PhD) Benjamin Mantell Metabolic Crosstalk Between Cells and the Liver in Obesity (F30, Mentor: Robert O’Doherty, PhD) Jason Sanders Epidemiology <strong>of</strong> Lens Aging in Older Women (F30, Mentor: Anne Newman, MD, MPH) Congratulations, Doctor! Recently Awarded PhDs James Bales Dopamine and Camp Regulated Phosphoprotein, 32 KDA: A novel therapeutic target in traumatic brain injury, Advisor: Edward Dixon, PhD (Neuroscience, Pitt) Christin Glorioso Between Destiny and Disease: Genetics and Molecular Pathways <strong>of</strong> Human Central Nervous System Aging, Advisor: Etienne Sibille, PhD (Neuroscience, Pitt) Carl Johnson Preclinical Biocompatibility Assessment <strong>of</strong> Pediatric Ventricular Assist Devices, Advisor: William Wagner, PhD (Bioengineering, Pitt) Gerald Nora Processing <strong>of</strong> Alternative DNA Structures in the Human Telomere, Advisor: Patricia Opresko, PhD (Molecular Biophysics/Structural Biology, Pitt) Aaron Secrest Mortality Trends in a Population-based Type 1 Diabetes Cohort, Advisor: Trevor Orchard, MBBCh, MMedSci (Epidemiology, Pitt) Michael Thompson β-cantenin: A friend or foe in liver pathobiology, Advisor: Satdarshan Monga, MD (Cellular & Molecular Pathology, Pitt) Student Announcements 6 David Wheeler (G3) and Amir Faraji (G4) attended the 2010 Nobel Laureate Meeting at Lindau (Germany) from June 27- July 2, 2010. Amir was sponsored by the NIH and David was sponsored by the Oak Ridge Associated Universities (ORAU). Lola Grace Grimm Secrest (6 lb 11 oz, 19.5 inches) was born to Aaron (MS3) and Katie Secrest on June 26, 2010.
New <strong>MSTP</strong> Student Publications through September 2010 Kaczorowski, D.J., Afrazi, A., Scott, M.J., Kwak, J.H., Gill, R., Edmonds, R.D., Liu, Y., Fan, J., and T.R. Billiar. (2010). Pivotal Advance: <strong>The</strong> pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. J Leukoc Biol.Oct; 88(4):609-18. [PMID: 20413727] Richardson, W.M., Sodhi, C.P., Russo, A., Siggers, R.H., Afrazi, A., Gribar, S.C., Neal, M.D., Dai, S., Prindle, T. Jr, Branca, M., Ma, C., Ozolek, J., Hackam DJ. (2010). Nucleotide-binding oligomerization domain-2 inhibits toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology. Sep; 139(3):904-17, 917. e1-6. [PMID: 20580721] Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W., and C.E. Dixon. (2010). Alterations in calcineurin subunit B is<strong>of</strong>orm expression in rat hippocampus following a traumatic brain injury. Brain Res. Oct 28; 1358:211-20. [PMID: 20713027] Bridges, J.P., Ikegami, M., Brilli, L.L., Chen, X., Mason, R.J., and J.M. Shannon. (2010). LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice. J. Clin. Invest. May 3; 120(5):1736-48. [PMID: 20407208] Chan, V., Starr, P.A., and R.S. Turner. (2010). Bursts and oscillations as independent properties <strong>of</strong> neural activity in the parkinsonian globus pallidus internus. Neurobiol. Dis. Aug 18 [Epub ahead <strong>of</strong> print; PMID: 20727974] Chao, Y.*, Shepard, C.R.*, and A. Wells. (2010). Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer. Jul 7; 9(1):179. [PMID: 20609236] Rajagopalan, M.S., Stone, B., Rwigema, J.C., Salimi, U., Epperly M.W., G<strong>of</strong>f, J., Franicola, D., Dixon, T., Cao, S., Zhang, X., Buchholz, B.M., Bauer, A.J., Choi, S., Bakkenist, C., Wang, H., and J.S. Greenberger. (2010). Intraesophageal Manganese Superoxide Dismutase-Plasmid Liposomes Ameliorates Novel Total- Body and Thoracic Radiation Sensitivity <strong>of</strong> NOS1(-/-) Mice. Radiat Res. Sep; 174(3):297-312. [PMID: 20726721] White, J.S., Choi, S., and C.J. Bakkenist. (2010). Transient ATM kinase inhibition disrupts DNA damage induced sister chromatid exchange. Sci Signal. Jun 1; 3(124):ra44. [PMID: 20516478] Choi, S., Gamper, A.M., White, J.S., and C.J. Bakkenist. (2010). Inhibition <strong>of</strong> ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility <strong>of</strong> ATM kinase inhibitors. Cell Cycle. Oct 15; 9(20):4052-7. [PMID: 20953138] Frank, G.M.*, Divito, S.J.*, Maker, D.M., Xu, M., and R.L. Hendricks. (2010). A novel p40-independent function <strong>of</strong> IL-12p35 is required for progression and maintenance <strong>of</strong> herpes stromal keratitis. Invest Ophthalmol Vis Sci. Jul;51(7):3591-8. [PMID: 20207959] *Co-first authors Divito, S.J., Wang, Z., Shufesky, W.J., Liu, Q, Tkacheva, O.A., Montecalvo, A., Erdos, G., Larregina, A.T., and A.E.Morelli. (2010). Endogenous dendritic cells mediate the effects <strong>of</strong> intravenously injected therapeutic immunosuppressive dendritic cells in transplantation. Blood. Oct 14;116(15):2694-705. [PMID: 20576812] Divito, S.J. and L.K. Ferris. (2010). Advances and short-comings in the early detection <strong>of</strong> melanoma. Melanoma Res. Dec; 20(6):450-8. [PMID: 20856147] Marenco, S., Savostyanova, A., van der Veen, J.W., Geramita, M., Stern, A., Barnett, A.S., Kolachana, B., Radulescu, E., Zhang, F., Callicott, J.H., Straub, R.E., Shen, J. and D.R. Weinberger. (2010). Genetic modulation <strong>of</strong> GABA levels in the anterior cingulate cortex by GAD1 and COMT. Neuropsychopharmacology. Jul;35(8):1708- 17. [PMID: 20357758] Glorioso, C., Oh, S., Duillard, G. and E. Sibille. (2010). Brain molecular aging, promotion <strong>of</strong> neurological disease and modulation by Sirtuin5 longevity gene polymorphism. Neurobiol Dis. Sep 29. [Epub ahead <strong>of</strong> print; PMID: 20887790] Wang, L, Gordon, R.A., Huynh, L., Su, X., Park Min, K.H., Han, J., Arthur, J.S., Kalliolias, G.D., and L.B. Ivashkiv. (2010). Indirect inhibition <strong>of</strong> Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity. Apr 23; 32(4):518-30. [PMID: 20362473] Gupta, A.S., van der Meer, M.A.A., Touretzky, D.S., and A.D. Redish. (2010). Hippocampal replay is not a simple function <strong>of</strong> experience. Neuron. Mar 11; 65(5):695- 705. [PMID: 20223204] Haldar, M., Hedberg, M.L., Hockin, M.F., and M.R. Capecchi. (2009). A CreER based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer Res. Apr 15; 69 (8):3657-64. [PMID: 19351831] Marcu, J.P., Christian, R.T., Lau, D., Zielinski, A.J., Horowitz, M.P., Lee, J., Pakdel, A., Allison, J., Limbad, C., Moore, D.H., Yount, G.L., Desprez, P.Y., and S.D. McAllister. (2010). Cannabidiol enhances the inhibitory effects <strong>of</strong> Δ9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival. Mol Cancer <strong>The</strong>r. Jan; 9(1):180-9. [PMID: 20053780] Horowitz, M.P. and J.T. Greenamyre. (2010). Mitochondrial iron metabolism and its role in neurodegeneration. J Alzheimer’s Dis. 20 Suppl. 2: S551-68. [PMID: 20463401] Horowitz, M.P. and J.T. Greenamyre. (2010). Gene-environment interactions in Parkinson’s disease: <strong>The</strong> importance <strong>of</strong> animal modeling. Clin Pharmacol and <strong>The</strong>r. Oct; 88(4):467-74. [PMID: 20811350] Bosch, J.J., Iheagwara, U.K., Reid, S., Srivastava, M.K., Wolf, J., Lotem, M., Ksander, B.R., and S. Ostrand-Rosenberg. (2010). Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8(+) cytotoxic, tumor-specific T cells. Cancer Immunol Immunother. Jan; 59(1):103-12. [PMID: 19557412] Johnson, C.A. Jr., Vandenberghe, S., Daly, A.R., Woolley, J.R., Snyder, S.T., Verkaik, J.E., Ye, S.H., Borovetz, H.S., Antaki, J.F., Wearden, P.D., Kameneva, M.V., and W.R. Wagner. (2010). Biocompatibility assessment <strong>of</strong> the first generation Pedia- FlowTM Pediatric Ventricular Assist Device. Artif Organs. Jul 9 [Epub ahead <strong>of</strong> print; PMID: 20626737] Ye, S.Ho., Johnson, C.A. Jr., Woolley, J.R., Murata, H., Gamble, L.J., Ihsihara, K., and W.R. Wagner. (2010). Simple surface modification <strong>of</strong> a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity. Colloids Surf B Biointerfaces. Sep 1; 79(2):357-64. [PMID: 20547042] Zhong, Z., Chang, S.A., Kalinowski, A., Wilson, K.L., and K.N. Dahl. (2010). Stabilization <strong>of</strong> the spectrin-like domains <strong>of</strong> nesprin-1alpha by the evolutionarily conserved “adaptive” domain. Cell Mol Bioeng. Jun 1; 3(2):139-150. [PMID: 20563238] Dahl, K.N., Kalinowski, A., and K. Pekkan. (2010). Mechanobiology and the microcirculation: cellular, nuclear and fluid dynamics. Microcirculation. Apr; 17(3):179-91. [PMID: 20374482] Kliment, C.R., and T.D. Oury. (2010). Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med. Sep 1; 49(5):707-17. [PMID: 20452419] Houghton, A.M., Rzymkiewicz, D.M., Ji, H., Gregory, A.D., Egea, E.E., Metz, H.E., Stolz, D.B., Land, S.R., Marconcini, L.A., Kliment, C.R., Jenkins, K.M., Beaulieu, K.A., Mouded, M., Frank, S.J., Wong, K.K., and S.D. Shapiro. (2010). Neutrophil elastase mediated degradation <strong>of</strong> IRS-1 accelerates lung tumor growth. Nat Med. Feb; 16(2):219-23. [PMID: 20081861] Koenitzer, J.R., and B.A. Freeman. (2010). Redox signaling in inflammation: interactions <strong>of</strong> endogenous electrophiles and mitochondria in cardiovascular disease. Ann NY Acad Sci. Aug; 1203:45-52. [PMID: 20716282] Polk, A.A., Maul, T.M., McKeel, D.T., Snyder, T.A., Lehocky, C.A., Pitt, B., Stolz, D.B., Federspiel, W.J., and W.R. Wagner. (2010). A biohybrid artificial lung prototype with active mixing <strong>of</strong> endothelialized microporous hollow fibers. Biotechnol Bioeng. Jun 15; 106(3):490-500. [PMID: 20091735] Tottey, S., Corselli, M., Jeffries, E.M., Londono, R., Peault, B., and S.F. Badylak. (2010). Extracellular matrix degradation products and low oxygen conditions enhance the regenerative potential <strong>of</strong> perivascular stem cells. Tissue Eng Part A. Sep 6. [Epub ahead <strong>of</strong> print; PMID: 20653348] Ho, A.W., Shen, F., Conti, H.R., Patel, N., Childs, E.E., Peterson, A.C., Hernandez- Santos, N., Kolls, J.K., Kane, L.P., Ouyang, W., and S.L. Gaffen. (2010). IL-17RC Is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol. Jul 15; 185(2):1063-70. [PMID: 20554964] Ruffner, M.A., and P.D. Robbins. (2010). Dendritic cells transduced to express IL-4 prevent diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS ONE. Jul 29; 5(7):e11848. [PMID: 20686610] Sanders, J.L., Cappola, A.R., Arnold, A.M., Boudreau, R.M., Chaves, P.H., Robins, J., Cushman, M., and A.B. Newman. (2010). Concurrent change in dehydroepiandrosterone sulfate (DHEAS) and functional performance in the oldest old: results from the Cardiovascular Health Study All Stars Study. J Gerontol A Biol Med Sci. Sep; 65(9):976-81. [PMID: 20466773] Orchard, T.J., Secrest, A.M., Miller, R.G., and T. Costacou. (2010). In the absence <strong>of</strong> renal disease, 20-year mortality risk in type 1 diabetes is comparable to that <strong>of</strong> the general population: A report from the <strong>Pittsburgh</strong> Epidemiology <strong>of</strong> Diabetes Complications Study. Diabetologia. Nov; 53(11):2312-9. [PMID: 20665208] Secrest, A.M., Becker, D.J., Kelsey, S.F., LaPorte, R.E., and T.J. Orchard. (2010). Cause specific mortality trends in a large population-based cohort with longstanding childhood-onset type 1 diabetes: <strong>The</strong> Allegheny County Type 1 Diabetes Registry. Diabetes. Aug 25. [Epub ahead <strong>of</strong> print; PMID: 20739685] Stetten, G., Horvath, S., Galeotti, J., Shukla, G., and B. Chapman, (2010). Image segmentation using the student’s ttest on adjacent spherical populations <strong>of</strong> pixels.” SPIE Medical Imaging, paper #7623-125, poster presentation 12/14-15/2010. Galeotti, J., Sajjad, A., Wang, B., Kagemann, L., Shukla, G., Siegel, M., Wu, B., Klatzky, R., Wollstein, G., Schuman, J., and G. Stetten. (2010). <strong>The</strong> OCT penlight: In-situ image guidance for microsurgery. SPIE Medical Imaging, paper #7625-1, oral presentation 12/14/2010. Svilar, D., Goellner, E.M., Almeida, K.H., and R.W Sobol. (2010). Base Excision Repair and lesion-dependent sub-pathways for repair <strong>of</strong> oxidative DNA damage. Antioxid Redox Signal. Oct 28. [Epub ahead <strong>of</strong> print; PMID: 20649466] Drowley, L., Okada, M., Beckman, S., Vella, J., Keller, B., Tobita, K., and J. Huard. (2010). Cellular antioxidant levels influence muscle stem cell therapy. Mol <strong>The</strong>r. Oct; 18(10):1865-73. [PMID: 20664528] Stetler, R.A., Gao, Y., Zukin, R.S., Vosler, P.S., Zhang, L., Zhang, F., Cao, G., Bennett, M.V.L. and J. Chen. (2010). Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. Proc Natl Acad Sci. Feb 16; 107(7) 3204-9. [PMID: 20133634] Romero, G., Sneddon, W.B., Yang, Y., Wheeler, D.S., Blair, H.C., and P.A. Friedman. (2010). Parathyroid hormone receptor directly interacts with dishevelled to regulate beta-Catenin signaling and osteoclastogenesis. J Biol Chem. May 7; 285(19):14756-63. [PMID: 20212039] Wheeler, D.S., Barrick, S.R., Grubisha, M.J., Brufsky, A.M., Friedman, P.A., and G. Romero. (2010). Direct interaction between NHERF1 and Frizzled regulates betacatenin signaling. Oncogene. Aug 30. [Epub ahead <strong>of</strong> print; PMID: 20802536] Jiao, J.A., Kelly, A.B., Marzec, U.M., Nieves, E., Acevedo, J., Burkhardt, M., Edwards, A., Zhu, X.Y., Chavaillaz, P.A., Wong, A., Wong, J.L., Egan, J.O., Taylor, D., Rhode, P.R., and H.C. Wong. (2010). Inhibition <strong>of</strong> acute vascular thrombosis in chimpanzees by an anti-human tissue factor antibody targeting the factor X binding site. Thromb Haemost, Jan; 103(1):224-33. [PMID: 20062929] 7
Change language