Cleveland Clinic Lerner Research Institute

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A Legacy of Research Focusing on the Patient “It is through The Cleveland Clinic Foundation … that a continual policy of active investigation of disease will be assured. That is to say, we are considering not only our duty to the patient of today, but no less our duty to the patient of tomorrow.” George W. Crile, MD Founder, Cleveland Clinic, at the opening of the first Cleveland Clinic building on February 26, 1921 “It seems to me a pity either to weaken or lose the research approach to the patients’ problems, which has always been an integral part of good medical practice, or to lose the humanitarian philosophy of the good doctor.” Irvine H. Page, MD First Division Chair (1945-1966) “From the 1940s to the late 1960s, the Division of Research was a hub of advanced laboratory and clinical hypertension studies. It wasn’t until the 1970s that funding from the National Institutes of Health [NIH] became the prime source of competitively awarded research funding. Our investigators, with proven scientific innovations, were well positioned to compete, and one of the first successful NIH awards was a large program grant in hypertension research.” F. Merlin Bumpus, PhD Division Chair (1967-1984) “From its founding, strong research and education were wrapped around the Cleveland Clinic’s central mission of better care for the patient. Research programs so designed and integrated inspire and inform scientists, no matter how basic their research, to keep their eyes on the patient’s problems. With this vision, and immersed in a powerful ever-improving clinical environment, research becomes inherently translational — and exciting. After all, isn’t that why we invest in medical research, why the NIH has flourished and why The Cleveland Clinic has sustained its own special quality on behalf of those we serve?” “A strong basic research establishment is a vital part of a strong academic clinical institution. You can’t have good translational research without good basic research.” George Stark, PhD Division Chair (1992-2002) Bernadine Healy, MD Division Chair (1985-1991)
Welcome to the Lerner Research Institute From its earliest days, Cleveland Clinic envisioned and encouraged an environment of discovery and an atmosphere that fostered communication and collaboration among laboratory-based and clinical researchers. Today, this philosophy and culture continues to serve Cleveland Clinic’s mission – to provide the highest-quality patient care. The medical care available today would not be possible without the research discoveries of the past. And today’s investigations pave the way for new interventions and therapies that will have great positive impact on the lives of patients of tomorrow. Lerner Research Institute encompasses the complete breadth of research, from the laboratory bench where discoveries are made to projects that translate those discoveries into new treatments that are tested in clinical trials. For example, current research projects encompass discovering new ways protein synthesis is regulated, identifying a new human virus, determining the clinical effectiveness of new treatments for diseases, and designing evidencebased decison models for physicians when treating prostate cancer, etc. With 11 research departments and nearly 2,000 full-time employees, Lerner Research Institute continues to grow in its stature as a premier biomedical research institute in the United States. Our research strength is founded upon the fact that our investigators ask highly significant and innovative questions that are focused on specific diseases. This approach encourages laboratory-based and clinical researchers to work closely with each other – to share ideas, observations and their diverse talents to effectively and efficiently translate discoveries into world-class patient care. We’ve expanded our research efforts in recent years into emerging areas that have a high potential for novel ways to treat disease. We created the Genomic Medicine Institute, which encompasses state-of-the-art genomics research, clinical care and counseling. The Department of Stem Cell Biology and Regenerative Medicine was begun to take full advantage of this promising field of medical research in identifying novel paradigms in the generation of cell types and in the development of therapeutics to be used in the treatment of diseases that result from the destruction of tissue. The Institute’s investigators also play critical roles as faculty in two groundbreaking educational programs: The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and The Molecular Medicine PhD Program. Together, these programs train tomorrow’s clinicianscientists and translational researchers who will lead the way in conducting biomedical research. We are committed to conducting world-class biomedical research, to speed delivery of new therapies and treatments, and to maintain an environment of collegiality and multidisciplinary collaboration. Paul E. DiCorleto, PhD The Sherwin-Page Chair Institute Chair
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Cleveland Clinic Lerner Research Institute

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