Beyond IUI, IVF and ICSI - eshre
Beyond IUI, IVF and ICSI - eshre
Beyond IUI, IVF and ICSI - eshre
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Microfluidic Sperm Sorter:<br />
Strengths <strong>and</strong> Weaknesses<br />
Strengths:<br />
1. Ease of use / disposable<br />
2. No centrifugation ti needed<br />
d<br />
- reduce physical<br />
or DNA damage<br />
3. Toxicology testing<br />
- freest<strong>and</strong>ing, no<br />
power source<br />
needed<br />
Weaknesses:<br />
1. Only uses 40 l semen<br />
- solution maybe<br />
multi-channels<br />
l<br />
2. Efficiency hard to predict<br />
- under some<br />
circumstances<br />
unimportant<br />
3. Not compatible with current<br />
<strong>IVF</strong> insemination techniques<br />
Microfluidic Sperm Sorter:<br />
Final Thoughts<br />
With respect to ART therapeutic use, the microfluidic<br />
sperm sorter by itself may seem unremarkable.<br />
The power of the device lies in its integration into a<br />
microfluidic system that is in development.<br />
Micro-insemination <strong>and</strong> Potential Use of<br />
Microfluidics in Embryo Development<br />
Intracytoplasmic Sperm Injection (<strong>ICSI</strong>)<br />
1) Revolutionized treatment of severe male factor infertility<br />
2) Invasive<br />
- 5-7% oocytes lysed<br />
- spindle damage <strong>and</strong> aneuploidy (?)<br />
- bypasses natural selection<br />
3) Long-term safety unknown<br />
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