Beyond IUI, IVF and ICSI - eshre
Beyond IUI, IVF and ICSI - eshre
Beyond IUI, IVF and ICSI - eshre
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Nuclear vacuoles <strong>and</strong> sperm competence<br />
• DNA Integrity<br />
• Mitochondrial function<br />
• Chromosomal aberrations<br />
What Are Sperm Vacuoles?<br />
Nuclear vacuoles are irregular entities in the condensed<br />
chromatin <strong>and</strong> are not limited by a membrane<br />
Vacuoles occur commonly in human sperm nuclei but<br />
are generally observable only with TEM<br />
Palermo et al., 2011<br />
Are sperm vacuoles responsible<br />
for DNA damage?<br />
6600x<br />
SCD TUNEL<br />
Palermo FISH et al., 2011<br />
Page 40 of 127
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