History of Clinical Research - IPPCR Video and Handout Archive

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History of Clinical Trials “Then Daniel said to the steward… Test your servants for ten days; let us be given vegetables to eat and water to drink. Then let our appearance and the appearance of the youths who eat the king’s rich food be observed by you, and according to what you see, deal with your servants. So he harkened to them in this matter; and tested them for ten days. At the end of ten days it was seen that they were better in appearance and fatter in flesh than all the youths who ate the king’s rich food. So the steward took away their rich food and dthe wine they were to drink, di and gave them vegetables.” Daniel 1:11 – 16 c. 530 BC
Iranian Medicine: Al Rhazi and Ibn Sina Al Rhazi (865-925): •Discovered use of alcohol as antiseptic •Contributions to medicine, alchemy, and philosophy •1 st treatise on pediatrics •recorded in over 184 books and articles Ibn Sina - Avicenna (973-1037): • Leader in pharmacy, philosophy, medicine and pharmacology • Wrote the Canon of Medicine, main European medical textbook of 14 th –16 th c. • Text contains 1 st known treatise on clinical trials – provided foundation for systematic approach to drug testing
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Page 3 and 4: 2010-20112011 IPPCR Enrollment Data
Page 5 and 6: IPPCR 32 Participating Off-Campus S
Page 7: IPPCR Administrative Comments • C
Page 10 and 11: Introduction to the Principles & Pr
Page 16 and 17: Definition of Clinical Research •
Page 18 and 19: Ancient Chinese Medicine 2737 B.C.
Page 20 and 21: Susruta: Father of Indian Surgery R
Page 22 and 23: Hippocrates’ Accomplishments •
Page 24 and 25: Galen • Greek physician lived 6 c
Page 28 and 29: Ibn Sina (Avicenna) “The Canon of
Page 31 and 32: Antonj Van Leeuwenhoek (1632-1723)
Page 33 and 34: Sir Christopher Wren (1632-1723) 17
Page 35 and 36: History of Clinical Trials James Li
Page 37 and 38: Story of Smallpox
Page 39 and 40: Small Pox in American History • 1
Page 41 and 42: Epidemiology
Page 43 and 44: Washing Hands
Page 45 and 46: Ignaz P. Semmelweis (1818-1865) 186
Page 47: History of Clinical Trials Semmelwe
Page 50 and 51: Story of Antisepsis Joseph Lister (
Page 52 and 53: Claude Bernard (1813-1878) 1878) Bo
Page 54 and 55: Surgery
Page 56 and 57: Immunology
Page 58 and 59: Robert Koch (1843-1910) 1910) Born
Page 60 and 61: Paul Ehrlich (1854-1915) 1915) Born
Page 62 and 63: End of 19 th Century: Women in Clin
Page 64 and 65: Accomplishments: Marie Curie (1867
Page 66 and 67: Benjamin Franklin In 1784: • King
Page 68 and 69: Statistics - Randomization
Page 70: Medical Research Council trial led
Page 73 and 74: Medical Research Ethics
Page 75 and 76: Informed Consent at the NIH Clinica
Page 77:
History of Clinical Research - A Me
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History of Clinical Research - IPPCR Video and Handout Archive

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