Asian Journal of Pharmacodynamics and Pharmacokinetics

Xu HY et al. Asian Journal of Pharmacodynamics and Pharmacokinetics 2009; 9(1):11-25
Rhizoma Coptidis is a very useful herb in
traditional oriental medicine. Cheng [58] did statistics
of 13 reciping books before the Song Dynasty in
which Chinese medicinal formulaes including
Rhizoma Coptidis were approximate 5 percentage of
all. There are many known formulaes having
continued to be used until now such as Zuojinwan
(including Rhizoma Coptidis and Fructus Evodiae, 6
1)Fanzuojinwan (including Rhizoma Coptidis and
Fructus Evodiae16), Coptidis Decoction for
Detoxification(including Rhizoma Coptidis, Radix
Scutellariae, Cortex Phellodendri and Gardenia
jasminoides Ellis).
Most chemical constituents of Rhizoma Coptidis
had been found and total alkoids had been thinked as
main active components espcially berberine.
Pharmacological action of Coptis chinensis and
berberine had been studied systematically.Both in
Traditional Chinese and Western Medicine,berberine
was widly applied to treat with infectious diseases
including not only mainly gastrointestinal bacterial
infection but also respiratory infection and
dermatologic infection. Recently, new pharmacologic
action such as anticancer, hypoglycemic activity
improving function of the circulatory system are
more and more paid attention to by people. With the
development of the living standard of the people and
aging of societal population, the incidence of
diabetescardiovascular disease and hypertension
were increasing and both Coptis chinensis and
berberine have good efficacy to treat with these
diseases. Bescause of extensive pharmacologic
effects and affluent resource of Coptis chinensis in
China , it is worth doing more in-depth research on
its chemical composition and pharmacologic action
and making full use of it.
Acknowledgement This project was
supported by National Key Technologies R&D
Program of China in the Eleventh h Five-year Plan
under Grant No. 2006BAI06A01 and
No.2007BAI41B06
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