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The Geometry The Nucleus

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Curing AIDS by Mastering<br />

<strong>The</strong><br />

Harmonies<br />

Of Cell<br />

Mitosis<br />

No single biological question<br />

allows us to more directly<br />

confront the fundamentals of<br />

living processes—from curing<br />

AIDS to counteracting the aging<br />

process—than mitosis, the<br />

capacity of living organisms to<br />

grow, reproduce themselves, and<br />

transmit information to their progeny.<br />

by Warren J. Hamerman<br />

M. S :hliwa, <strong>The</strong> Cytoskeleton (New York: Springer-Verlag, 1986), p. 50.<br />

Viewed from the standpoint of mitosis, the overall<br />

capacity of living organisms to reproduce themselves<br />

is virtually continuous. In the human being's<br />

bone marrow and other high mitotic areas, for example, 10-<br />

million cell divisions are occurring every second. <strong>The</strong> frontiers<br />

of 21st century biology will be shaped by science's<br />

success in understanding how this mitotic process is<br />

"tuned," its species-specific and tissue-specific harmonic<br />

laws, and the nature of the overall "musical system" within<br />

which healthy living forms have the freedom to lawfully<br />

develop, differentiate, proliferate, and evolve.<br />

Just as surely as Johannes Kepler's discovery and Karl<br />

Gauss's later elaboration of the harmonies of the planetary<br />

solar system unveiled the mysteries of astrophysics, so too<br />

will the study of the harmonies of cell mitosis and cell division<br />

unveil the mysteries of the living process.<br />

<strong>The</strong> unique biological feature of the slow-acting AIDS<br />

virus is that when it infects a cell, the genetic message or<br />

genome of the virus migrates to the nucleus, where it in-<br />

<strong>The</strong> geometric ordering of the cell is beautifully evident in<br />

this chicken embryo fibroblast, as seen by immunofluorescence<br />

microscopy.<br />

corporates its :lf into the normal genetic message of the<br />

cell. Although the virus's genome succeeds in getting incorporated<br />

in o the host cell's DNA, it may lie dormant<br />

across many iiell divisions of the parent cell before the<br />

virus's messag e takes over, expresses itself while the cell is<br />

undergoing m tosis, and turns the cell into a virus "factory."<br />

What is the lature of the "activation signal" that converts<br />

a latent inf ecti Dn into an actual one? This is one of the most<br />

central questiDns of AIDS research. <strong>The</strong>re is currently a<br />

debate in the scientific community over whether the activation<br />

signal s an antigenic or a mitogenic stimulus, or<br />

both. (An anti »enic signal refers to a stimulus from an antigen<br />

or protei T specific to another disease to which the<br />

immune syste n is responding; a mitogenic stimulus results<br />

from a specifi : growth factor associated with cell division.)<br />

No matter wr at the origin, however, the signal's "tuning<br />

mechanism nust be governed by the same fundamental<br />

process, and it is theoretically possible to send the cell<br />

nucleus a "deactivation" signal instead of an "activation"<br />

signal<br />

Perhaps thd most important biological clue to the unique<br />

nature of AIDS is that when the virus is activated, it causes<br />

the cells it irfects to rapidly divide and grow, fusing or<br />

clumping tog ;ther with hundreds and thousands of other<br />

21st(ENTURY May-June 1988 31

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