open access: Nature Reviews: Key Advances in Medicine
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UROLOGY<br />
Division of Urologic Oncology, Department of<br />
Surgery, Fox Chase Cancer Center, 333<br />
Cottman Avenue, Philadelphia, PA 19111, USA<br />
(M. C. Smaldone, R. G. Uzzo).<br />
Correspondence to: R. G. Uzzo<br />
r_uzzo@fccc.edu<br />
Compet<strong>in</strong>g <strong>in</strong>terests<br />
The authors declare no compet<strong>in</strong>g <strong>in</strong>terests.<br />
1. Go, A. S., Chertow, G. M., Fan, D.,<br />
McCulloch, C. E. & Hsu, C. Y. Chronic kidney<br />
disease and the risks of death, cardiovascular<br />
events, and hospitalization. N. Engl. J. Med.<br />
351, 1296–1305 (2004).<br />
2. Campbell, S. C. et al. Guidel<strong>in</strong>e for<br />
management of the cl<strong>in</strong>ical T1 renal mass.<br />
J. Urol. 182, 1271–1279 (2009).<br />
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<strong>in</strong> <strong>Nature</strong> <strong>Reviews</strong> Urology. Research Highlights, News & Views, <strong>Reviews</strong>,<br />
and Perspectives—you won’t miss a th<strong>in</strong>g!<br />
http://www.nature.com/register<br />
3. Van Poppel, H. et al. A prospective, randomised<br />
EORTC <strong>in</strong>tergroup phase 3 study compar<strong>in</strong>g the<br />
oncologic outcome of elective nephron-spar<strong>in</strong>g<br />
surgery and radical nephrectomy for low-stage<br />
renal cell carc<strong>in</strong>oma. Eur. Urol. 59, 543–552<br />
(2011).<br />
4. Simhan, J. et al. Objective measures of renal<br />
mass anatomic complexity predict rates of<br />
major complications follow<strong>in</strong>g partial<br />
nephrectomy. Eur. Urol. 60, 724–730 (2011).<br />
5. D<strong>in</strong>do, D., Demart<strong>in</strong>es, N. & Clavien, P. A.<br />
Classification of surgical complications: a new<br />
proposal with evaluation <strong>in</strong> a cohort of 6336<br />
patients and results of a survey. Ann. Surg.<br />
240, 205–213 (2004).<br />
6. Kutikov, A. & Uzzo, R. G. The R.E.N.A.L.<br />
nephrometry score: a comprehensive<br />
standardized system for quantitat<strong>in</strong>g renal<br />
tumor size, location and depth. J. Urol. 182,<br />
844–853 (2009).<br />
7. Holl<strong>in</strong>gsworth, J. M., Miller, D. C., Daignault, S. &<br />
Hollenbeck, B. K. Ris<strong>in</strong>g <strong>in</strong>cidence of small renal<br />
masses: a need to reassess treatment effect.<br />
J. Natl Cancer Inst. 98, 1331–1334 (2006).<br />
8. Chawla, S. N. et al. The natural history of<br />
observed enhanc<strong>in</strong>g renal masses: metaanalysis<br />
and review of the world literature.<br />
J. Urol. 175, 425–431 (2006).<br />
9. Jewett, M. A. et al. Active surveillance of small<br />
renal masses: progression patterns of early<br />
stage kidney cancer. Eur. Urol. 60, 39–44 (2011).<br />
10. Smaldone, M. C. et al. Small renal masses<br />
progress<strong>in</strong>g to metastases under active<br />
surveillance: A systematic review and pooled<br />
analysis. Cancer http://dx.doi.org/10.1002/<br />
cncr.26369.<br />
S86 | JANUARY 2012 www.nature.com/reviews