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Program Perspectives in Cell- and Gene-Based Medicines - DGTI

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<strong>Program</strong> Friday, March 16<br />

Friday, March 16<br />

Scientific Session 1 HZ 3<br />

08:30 - 10:30 Genome Eng<strong>in</strong>eer<strong>in</strong>g <strong>and</strong> Repair<br />

Chairs: Harald von Melchner, Frankfurt; Toni Cathomen, Hannover<br />

Inv7<br />

08:30 - 08:50<br />

Inv8<br />

08:50 - 09:10<br />

Inv9<br />

09:10 - 09:30<br />

OR1.1<br />

09:30 - 09:42<br />

OR1.2<br />

09:42 - 09:54<br />

OR1.3<br />

09:54 - 10:06<br />

OR1.4<br />

10:06 - 10:18<br />

OR1.5<br />

10:18 - 10:30<br />

CenH3 enhances gene vector ma<strong>in</strong>tenance by<br />

neo-centromere formation<br />

Aloys Schepers, Munich<br />

Insertion profiles of transposon based vectors<br />

<strong>and</strong> strategies for targeted transgene <strong>in</strong>sertion<br />

Zoltan Ivics, Langen<br />

Cut <strong>and</strong> paste - targeted genome eng<strong>in</strong>eer<strong>in</strong>g<br />

us<strong>in</strong>g designer nucleases<br />

Toni Cathomen, Hannover<br />

Designer nuclease platform comparison: ZFNs versus TALENs<br />

Claudio Mussol<strong>in</strong>o, Hannover<br />

Rapid generation of knock out cell l<strong>in</strong>es utiliz<strong>in</strong>g<br />

deep sequenc<strong>in</strong>g<br />

Tobias Schmidt, Bonn<br />

<strong>Gene</strong>ration of a tumor- <strong>and</strong> tissue-specific episomal non-viral<br />

vector system<br />

Manfred Ogris, Munich<br />

Identification of a doma<strong>in</strong> responsible for the dose-dependent<br />

antiproliferative <strong>and</strong> apoptotic effects of Sleep<strong>in</strong>g Beauty transposase<br />

Melanie Galla, Hannover<br />

Phenotypic correction of a X-CGD model cell l<strong>in</strong>e by targeted<br />

genome eng<strong>in</strong>eer<strong>in</strong>g<br />

Anne-Kathr<strong>in</strong> Dreyer, Hannover<br />

18<br />

Educational Session ISBT Academy 3 HZ 4<br />

08:30 - 10:30 Hematopoietic Stem <strong>Cell</strong> Transplantation <strong>and</strong> Graft<br />

Manipulation<br />

Chair: Anne Husebekk, Tromsø; Christian Seidl, Frankfurt<br />

08:30 - 09:00 Cl<strong>in</strong>ical applicability of stem cells from cord blood for<br />

transplantation<br />

Franco Locatelli, Pavia<br />

09:00 - 09:30 How does T-cell depleted grafts affect the cl<strong>in</strong>ical outcome of<br />

HSC transplantation<br />

Tobias Feucht<strong>in</strong>ger, Tüb<strong>in</strong>gen

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