here - Molecular Medicine Ireland
here - Molecular Medicine Ireland
here - Molecular Medicine Ireland
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
MMI Education & Training<br />
ANNUAL SCIENTIFIC MEETING 2013<br />
Science Gallery, Trinity College Dublin<br />
Thursday 14 March<br />
• MMI Clinical and Translational Research Scholars present their research<br />
as short talks and posters.<br />
• MMI Clinician Scientist Fellowship Programme alumni present their<br />
research and an update on their career plans.<br />
• The wider community pursuing Clinical & Translational research, with a<br />
particular focus on medical graduates, present posters on their work.<br />
• Opportunities to learn more about key initiatives to support clinical and<br />
translational research such as the Dublin Centre for Clinical Research<br />
and ICRIN.<br />
The MMI Annual Scientifi c Meeting has been approved for External Continuing Professional<br />
Development (CPD) Credits from the Royal College of Physicians of <strong>Ireland</strong> (6 Credits).
Programme<br />
MMI Education & Training Annual Scientific Meeting 2013<br />
Date: Thursday 14 March 2013<br />
Venue: Science Gallery, Trinity College Dublin<br />
0915 Registration + Tea / Coffee<br />
0930<br />
Welcome and Opening Remarks<br />
Professor Laurence Egan (Chair of Clinical Pharmacology and Head of the Department of Pharmacology and<br />
Therapeutics, NUI Galway)<br />
Session 1 Chair: Dr Douglas Veale (Consultant Rheumatologist, DAHC/St. Vincent’s University Hospital and Medical<br />
Director of SVUH Education and Research Centre)<br />
MMI Clinical & Translational Research Scholars Talks<br />
0945<br />
1000<br />
1015<br />
1030<br />
Karen Hanrahan (UCD)<br />
Epithelial-mesenchymal transition in docetaxel-resistant prostate cancer cell lines<br />
Marie Fitzgibbon (NUI Galway)<br />
Chronic pain associated with inflammation-induced depression: mechanisms and modulators<br />
Eilis Dockry (TCD)<br />
γδ TcCell Targeting of Non-Small Cell Lung Cancer and Mesothelioma cells using IL-23<br />
MMI Clinician Scientist Fellowship Programme Alumni Talk<br />
Dr Aonghus O'Loughlin (MMI Fellowship in National University of <strong>Ireland</strong>, Galway. Currently Specialist<br />
Registrar Diabetes and Endocrinology, Beaumont Hospital)<br />
Novel Cell-Based Therapies for Diabetic Ulceration<br />
1055 Poster Viewing + Tea / Coffee<br />
Session 2 Chair: Professor Geraldine Boylan (Director of the Neonatal Brain Research Group in UCC and Cork<br />
University Maternity Hospital)<br />
MMI Clinical & Translational Research Scholars Talks<br />
1125<br />
1140<br />
1155<br />
1210<br />
Niamh Denihan (UCC)<br />
Validation of early biomarkers in Hypoxic–ischaemic encephalopathy<br />
Stephanie Slevin (NUI Galway)<br />
Effect of Infliximab on monocyte subtypes in blood of patients with chronic inflammatory bowel disease.<br />
Trudy McGarry (UCD)<br />
Beta-1 integrin is a critical mediator of TLR2-induced cell migration and invasion in RA<br />
MMI Clinician Scientist Fellowship Programme Alumni Talk<br />
Dr Aoife Lowery (MMI Fellowship in National University of <strong>Ireland</strong>, Galway. Currently Specialist Registrar in<br />
Surgery, Beaumont Hospital, Dublin)<br />
MicroRNA - Biomarker and Therapeutic Potential in Breast Cancer<br />
1235 Poster Session (adjudicated) + Lunch
Session 3 Chair: Dr Aideen Long (Associate Professor, Institute of <strong>Molecular</strong> <strong>Medicine</strong>, TCD)<br />
MMI Clinical & Translational Research Scholars Talks<br />
1430<br />
1445<br />
1500<br />
Ciara Harty (UCC)<br />
Hepatitis C virus disruption of lipid and autophagy pathways provides an opportunity for the discovery of new<br />
adjunct therapies<br />
Rachel Bermingham (TCD)<br />
Functions of Innate Type 2 Lymphoid Cells in Inflammatory disorders<br />
MMI Clinician Scientist Fellowship Programme Alumni Talk<br />
Dr Fionnuala Ní Áinle (MMI Fellowship in Trinity College Dublin. Currently Consultant Haematologist, Mater<br />
Misericordiae Hospital, Dublin)<br />
Enhancing the Therapeutic Potential of Activated Protein C<br />
1525 Tea / Coffee + Poster Viewing<br />
Session 4 Chair: Professor Jonathan Hourihane (Head of Department of Paediatrics, University College Cork)<br />
1600 Clinician Scientist Keynote Lecture<br />
Professor Patrick Johnston<br />
(Head of the School of <strong>Medicine</strong>, Dentistry and Biomedical Sciences, Queen's University Belfast)<br />
Translational <strong>Medicine</strong>: An Evolving Paradigm<br />
1700<br />
Closing Remarks<br />
Dr Graham Love, Chief Executive, <strong>Molecular</strong> <strong>Medicine</strong> <strong>Ireland</strong><br />
1715 Presentation of Prizes & Wine Reception<br />
MMI Clinical & Translational Research Scholars Talks judging panel:<br />
<br />
<br />
Dr Aideen Long (Associate Professor, Institute of <strong>Molecular</strong> <strong>Medicine</strong>, TCD)<br />
Dr Douglas Veale (Consultant Rheumatologist, DAHC/St. Vincent’s University Hospital and Medical Director of<br />
SVUH Education and Research Centre)<br />
Posters judging panel:<br />
<br />
<br />
<br />
Dr Liam Fanning (Director, <strong>Molecular</strong> Virology Diagnostic & Research Laboratory & Senior Lecturer and<br />
Research Scientist, Department of <strong>Medicine</strong>, University College Cork & Cork University Hospital)<br />
Dr John Gormley (Director of Postgraduate Teaching and Learning, School of Research & Postgraduate<br />
Education, Trinity Centre for Health Sciences, St. James's Hospital)<br />
Dr Aideen O’Doherty (Clinical Research Coordinator, HRB Clinical Research Facility Galway, NUI Galway)
Posters from the wider community in Clinical &<br />
Translational Research<br />
MMI CTRSP Scholars Presenting Posters<br />
Posters<br />
No Presenting Author Poster Title<br />
1 Ayokunmi Ajetunmobi<br />
Development of a microelectrode array (mea) sensing biochip for the study of<br />
neuropsychiatric illness<br />
2 Eanna Connaughton Phenotypic, functional and molecular analysis of novel human monocyte subpopulations<br />
3 Roisin Dunne<br />
The effects of dual inhibition of angiogenesis and glycolysis to regulate neoadjuvant<br />
radiosensitivity in gastrointestinal cancers<br />
4 Oisin Gough Functional role of candidate genes emerging from GWAS in diabetic nephropathy.<br />
5 Michael Healy Investigation into the role of autophagy in chemo-resistant cancers<br />
6 Jennifer Hillis The pro-survival effect of NGF through the p75 ntr receptor in breast cancer<br />
7 Mark Jackson<br />
8 Lauren McDonagh<br />
9 Edel McGarry<br />
10 Niall Savage<br />
11 Wesley van Oeffelen<br />
Application of oxazoline containing ligands in palladium catalysed<br />
decarboxylation/protonation<br />
Validation and function of a novel miRNA signature in cisplatin resistant non-small cell<br />
lung cancer cells<br />
Role of the cell division cycle 7 kinase (cdc7) and claspin in the duplication of DNA and in<br />
the cellular response to chemotherapeutics drugs.<br />
Development of a smart needle integrated with a nanostructured impedance sensor for<br />
detection of breast cancer<br />
Mood, food and addiction: unraveling the interaction between hypothalamic peptides and<br />
mesolimbic dopamine signaling<br />
12 Julie Worrell The role and regulation of the CXCR3 receptor in pulmonary fibrosis<br />
13 Joe Chukwu<br />
Pharmacogenomic risk factors associated with sodium valproate-induced weight change<br />
in the paediatric population<br />
14 Genevieve Kelly Immune dysregulation in Hidradenitis Suppurativa [HS].<br />
15 Teresa Loftus Dublin Brain Bank<br />
16 Valerie Logan Rare kidney disease and vasculitis registry and bioresource<br />
17 David Murray<br />
18 Alice O'Farrell<br />
Guanine nucleotide exchange factors Dock7 and Ect2 mediate HGF/C-MET-induced<br />
glioblastoma cell invasion.<br />
Mechanistic interrogation of cardiac and vascular toxicities associated with the receptor<br />
tyrosine kinase inhibitor sunitinib: investigation of novel safety biomarkers of cardiotoxicity<br />
19 Alison Reynolds The application of zebrafish to drug discovery research<br />
20 Emma Roycroft A “snapshot” of genetic lineages of M. Tuberculosis in the Republic of <strong>Ireland</strong>, 2010-11<br />
The MMI Clinical & Translational Research Scholars Programme is funded under the Programme for Research in Third Level<br />
Institutions (PRTLI) Cycle 5, and co-funded under the European Regional Development Fund (ERDF)
Change language