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Targeting by probe-based circularisation

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Parallel sequencing of 177 exons in<br />

10 cancer genes<br />

454 sequencing<br />

59.000 reads per exp<br />

55%<br />

90% map to the selected<br />

sequence (49 kb) =><br />

Average enrichment:<br />

600.000<br />

10x<br />

508 <strong>probe</strong>s<br />

Dahl, et al. (2007) PNAS, 104, 9387-9392

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