Acute Kidney Injury
Acute Kidney Injury
Acute Kidney Injury
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Pharmacological Interventions in <strong>Acute</strong> <strong>Kidney</strong> <strong>Injury</strong><br />
Drug<br />
Biological<br />
rationale<br />
Animal<br />
experiments<br />
Uncontrolled<br />
human data<br />
Small<br />
RCT<br />
Large<br />
RCT<br />
Loop diuretics Present Favorable Favorable Negative N/A<br />
Low-dose dopamine Present Favorable Favorable Variable Negative<br />
Mannitol Present Favorable Favorable N/A N/A<br />
The only FDA<br />
Ca antagonist Present Favorable Favorable Variable N/A<br />
Theophylline Present Favorable Favorable Positive N/A<br />
approved treatment for<br />
Prostaglandins Present Favorable Favorable N/A N/A<br />
established AKI<br />
Natriuretic peptide Present Favorable Favorable Negative N/A<br />
α-receptor antagonist Present N/A N/A Positive N/A<br />
is dialysis<br />
Endothelin antagonist Present Favorable N/A N/A N/A<br />
Thromboxane antagonist Present Favorable N/A N/A N/A<br />
Thyroxine Present Favorable N/A Negative N/A<br />
Saline Present Favorable Favorable Positive N/A<br />
NAC Present Favorable N/A Positive N/A<br />
Non-ionic media Present Favorable Favorable Positive positive<br />
C. Ronco and R.Bellomo Nephron Clinical Practice 93:C13, 2003
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