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Telomeres<br />
<br />
The ends of eukaryotic chromo-somes<br />
are capped by short G-rich sequences<br />
(telomeres) that are tandemly<br />
repeated for several hundred to<br />
thousand base pairs.<br />
<br />
In humans the telomeric repeat is<br />
TTAGGG.<br />
<br />
Telomeres prevent chromosomal<br />
degradation, end-to-end fusion, and<br />
chromosomal rearrangements.<br />
Human telomeres shorten with each<br />
cell division.<br />
<br />
Telomeric shorten<strong>in</strong>g is thought to<br />
function as a molecular clock that<br />
triggers senescence and crisis.<br />
Haber, D.A. NEJM 332 (14):955 , 1995
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