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Acknowledgements Coworkers Cungui Mao Ruijuan Xu Helene Birbes Jackie Kraveka Korey Johnson Heather Greer Kashelle Othersen Tarek Taha Mark Venable Collaborators Yusuf Hannun Besim Ogretmen Alicia Bielawska Zdzislaw Szulc Julnar Usta Administrative Support Kathy Wiita National Institutes of Aging Veteran’s Administration Merit Award Paul Beeson Physician Faculty in Aging Award
Web site www.musc.edu/bcmb/ceramide
Page 1 and 2: Sphingolipid metabolism and functio
Page 3 and 4: Sphingolipid Metabolism
Page 5 and 6: Cellular Senescence: a model to stu
Page 7 and 8: Ceramide Levels and Sphingomyelinas
Page 9 and 10: Ceramide and cellular senescence C
Page 11 and 12: Background on Telomerase Telomeras
Page 13 and 14: Ceramide Inhibits Telomerase Activi
Page 15 and 16: Ceramide inhibits telomerase transc
Page 17 and 18: CONCLUSIONS Ceramide is a possi
Page 19 and 20: Bax Singomyelinase Ceramide
Page 21 and 22: Ceramide and Mitochondria 1. Activa
Page 23 and 24: Ceramide Levels in Liver Mitochondr
Page 25 and 26: Cellular localization of the bSMase
Page 27 and 28: Increase of ceramide levels in MCF7
Page 29: verexpression of the Mito-bSMase-D2
Page 32 and 33: Summery Evidence for a mitochondri

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