Handout in pdf

Sphingolipid function
evidence for roles for sphingolipids in
signaling and cell regulation
A: Modular Action
– Regulated metabolism of sphingolipids
– Multiple bioactive sphingolipids; sphingosine, ceramide,
sphingosine-1 phosphate, and others.
– Identification of targets for sphingolipid action: mechanisms of
action e.g. kinases, phosphatases and receptors.
– Deciphering mechanisms of regulation of sphingolipid metabolism.
– Molecular genetics of sphingolipid function in yeast.
B: Other Functions
– Critical membrane components: required for viability in yeast and
mammalian cells.
– Enzymes of sphingolipid metabolism as targets for anti fungals and
antibiotics
– Cell cell interactions
– Receptors for various ligands and toxins