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The Human Telomerase Ribonucleoprote<strong>in</strong> Complex<br />
The human telomerase complex<br />
consists of:<br />
• hTERT (the catalytic reverse<br />
transcriptase subunit)<br />
• hTR (the RNA template)<br />
• Telomerase associated prote<strong>in</strong>s:<br />
TEP1 & p23/hsp90<br />
• prote<strong>in</strong> components of snoRNPs<br />
<strong>in</strong>clud<strong>in</strong>g dysker<strong>in</strong><br />
• DNA-b<strong>in</strong>d<strong>in</strong>g prote<strong>in</strong>s TRF-1 & TRF-2<br />
• TRF-1 associated prote<strong>in</strong>s TIN2 &<br />
tankyrase<br />
• other associated prote<strong>in</strong>s<br />
Estimated molecular mass > 1000 kDA<br />
Shay, J.W. and Wright, W.E. Science 286;2284-2285 (1999).
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