CLARK Prescription Drug Abuse - Misuse Neurobiology Epidemiology EBPs

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One Size Does Not Fit All: Addiction Addiction involves the complex interaction of multiple, individual-specific factors including a person’s inherent biology as well as their environment, experience, and age. • Gene-environment interactions • Developmental stages • Mental health & stressful life events including physical & sexual abuse –Evidence that social factors and life experiences influence dopamine transmission pathway • Co-morbidities 22
Addiction: Neurobiological Interdependencies All of these brain regions must be considered in developing strategies to effectively treat addiction. Adapted from NIDA <strong>Drug</strong> <strong>Abuse</strong> & Addiction 23
Page 2 and 3: Prescription Drug Abuse & Misuse: N
Page 4 and 5: Secretary Kathleen Sebelius U.S. De
Page 6 and 7: Prescription Drugs Abuse & Misuse:
Page 8 and 9: Topics Neurobiology Epidemiology EB
Page 10 and 11: Addiction is a Chronic Brain Diseas
Page 12 and 13: Movement Motivation Dopamine Addict
Page 14 and 15: Slide courtesy of NIDA 14
Page 16 and 17: Dopamine & Exogenous Opioids: Hyper
Page 18 and 19: Other Neurotransmitter Systems Scie
Page 20 and 21: Opioid Binding Sites Adapted from N
Page 24 and 25: Topics Neurobiology Epidemiology Tr
Page 26 and 27: Past Month Nonmedical Use of Types
Page 28 and 29: Source Where Pain Relievers Were Ob
Page 30 and 31: Past Month and Past Year Heroin Use
Page 32 and 33: Past Year Initiates of Specific Ill
Page 34 and 35: Substances for Which Most Recent Tr
Page 36 and 37: Percentage of ED visits involving n
Page 38 and 39: Opioid Related Emergency Department
Page 40 and 41: Topics Neurobiology Epidemiology EB
Page 42 and 43: ROSC: A Way to Better Health for Al
Page 44 and 45: ROSC Framework Provides a coordinat
Page 46 and 47: One Size Does Not Fit All: Evidence
Page 48 and 49: Medication Assisted Treatment MAT i
Page 50 and 51: EBP: Rehabilitation & Therapeutic M
Page 52 and 53: EB Treatment is Complicated: Interd
Page 54 and 55: EBP Opioid Overdose Toolkit Over 23
Page 56 and 57: EBP Treatment Protocols and KAP Key
Page 58 and 59: EBP Consensus Guidelines (in proces
Page 60 and 61: EBP Literature Reviews September 20
Page 62 and 63: EBP: SBIRT’s Return-on-Investment
Page 64 and 65: SAMHSA Block Grants (Dollars in Tho
Page 66 and 67: Implementation of National Action P
Page 68 and 69: Key Takeaways of National Action Pl
Page 70 and 71: “Advancing Access to Addiction Me
Page 72:
THANK YOU! Westley.Clark@samhsa.hhs
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CLARK Prescription Drug Abuse - Misuse Neurobiology Epidemiology EBPs

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