2013 Career Development Award in Breast Cancer Research ...

Career Development Awards 

in Breast Cancer Research 

2013 Career Development Award in Breast Cancer Research 

Request for Proposal (RFP) 

A. Requirements 

Proposal due/electronic submission: Friday, March 15, 2013 (by 5:00 p.m.) 

Decision and earliest possible start: Wednesday, May 1, 2013 

B. Purpose 

Applicants are invited to apply for trainee research development funds for translational 

research projects related to breast cancer research. The development of the proposal 

should lead to additional breast cancer research or possible inclusion in a large multiproject 

grant proposal such as a SPORE application for NCI funding. 

C. Eligibility 

Eligible Candidates: 

Funds from this program may be used to support post-doctoral or clinical fellows (who 

will be independent investigators within the next few years), junior faculty, or established 

investigators who wish to develop or refocus their careers on translational research. 

Investigators supported by NCI career development awards (K series) may also be 

eligible for support through this program as allowable. 

Each junior level candidate (post-docs, clinical fellows, and assistant professors) 

should have a mentor(s) and devote a significant percentage of his/her effort to 

translational research. 

Eligible Mentors 

An ideal mentor would be a Siteman Cancer Center Member or Affiliate Member at the 

Assistant Professor level or higher, have strong and active records of conducting 

research studies and/or studies of breast cancer diseases, as well as strong leadership 

capabilities and substantial mentorship experiences. Applications will not be considered 

without a Letter of Support from their mentor. If you are from an external but 

collaborative institution or in need of assistance in selecting a mentor please contact 

Kyle Neeley (contact information below) as early as possible. 

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Individuals from underrepresented racial and ethnic groups as well as individuals 

with disabilities are always encouraged to apply for support. 

Research application must be relevant to breast-cancer research. 

Amount: One Career Award will be awarded up to $50,000 for one year. 

Required documents: All documents are required to be on the PHS 398 forms unless 

otherwise noted. All NIH forms can be found at: http://grants1.nih.gov/grants/forms.htm 

See following for pages more detailed instructions. 

1. Face page and Abstract (use SCC Face Page).This document is created as you 

enter the system. 

2. Budget (398 budget pages 4 attached) and Budget Justification (narrative) 

3. NIH Biosketches (include all sections) for any personnel relevant to the project and/or 

included in the budget 

4. Other Support Page (including effort) 

5. Research Plan (up to 5 pages) 

6. Literature Cited 

7. Letter of Support from Mentor 

8. Letter(s) of Support from other relevant sources 

9. Additional Information Page- such as description of Human Subjects status, etc. 

D. Instructions 

A web-based online system will be used. These are internal awards and are NOT 

submitted through the Grants & Contracts Office. You must apply online at: 

http://www2.siteman.wustl.edu/grantsubmission/Home.aspx 

For “type” of grant, choose “2013 Career Award in BC” 

You will upload documents (listed below) as either .pdf or Word documents. Please note 

the face page is created in the system – please use lay language for the Abstract. 

Budget form page are separate documents that you can link to below, then upload with 

your narrative and other supporting documents. 

Please put your name (last name, first initial) at the top or in the header of each 

page. Use Arial 11 point or larger for all text. 

1. Face Sheet 

Fill out face sheet document as instructed in the application system. 

2. Budget and Justification (use PHS 398 budget pages.) 

When completing the budget page, refer to the list of expenditures allowed and not 

allowed: 

Expenditures Allowed 

• Salary support for the applicant as needed 

• Research supplies and animal maintenance (including animal per diem charges) 

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• Per diem charges for patients if part of a clinical study not reimbursable by 

standard payment terms 

• Technical assistance 

• Publication costs, including reprints, study instruments, surveys, etc. 

• Costs of computer time 

• Special fees (pathology, photography, etc.) 

Expenditures NOT Allowed 

• Secretarial/administrative personnel salary support 

• Office equipment and supplies 

• Computer/equipment maintenance fees 

• Tuition 

• Indirect institutional costs 

3. NIH-formatted Biographical Sketch or a current CV 

Upload biosketch if you have one prepared, if not, please upload your current CV and 

that of your mentor or mentors. 

4. Research Plan (5 pages maximum) for A-E 

The following headings should be used for the research plan. 

A. Specific Aims (1/2 page maximum): State concisely the hypothesis to be tested 

and the specific aim(s) to be achieved during the grant period. The aims must be 

reasonable to achieve during the one-year period of the award. 

B. Significance to Breast Cancer Research (1/2-1 page maximum): State the 

relevance of the proposed project to basic, clinical, or prevention and control 

breast cancer research. Please specify if the project is translational or will lead to 

translational research opportunities. Discuss any potential utilization of the 

Siteman Core facilities. 

C. Background and Preliminary Investigations (1-1.5 pages maximum): Discuss 

the pertinent research findings that have been described in the scientific literature 

and how this proposal will add to these results. Also discuss any preliminary data 

obtained that are relevant to this proposal. 

D. Experimental Design and Methods (1-1.5 pages maximum): Concisely present 

the experimental design and the methods to be used to accomplish the specific 

aims. Also indicate how the results will be interpreted and how they will lead to 

future investigations. Well-known methods and standard procedures may be 

described very briefly or referenced, but novel experimental approaches should 

be outlined in more detail. 

E. Plans for Subsequent External Funding (1/2 page maximum): Describe plans 

for future, collaborative applications based on the proposed work. 

5. Literature Cited (Approximately 1 page) 

6. Letter of Support - Mentor 

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7. Letters of Support –Other 

Include letters from other sources such as cores you may utilize, Centers, community or 

government agencies, etc. if relevant to the project. 

8. Additional Information Page 

Human Research Studies: All new cancer-related research involving human subjects, 

and thus needing approval by the Human Research Protection Office (HRPO), must first 

be reviewed and approved by the Siteman Cancer Center Protocol Review and 

Monitoring Committee (PRMC). Funds will not be released prior to PRMC and HRPO 

approval. Please include a page explaining your project’s human participation, or the 

anticipated date you will be submitting to the PRMC/HRPO, and when approval is 

expected. 

9. Any questions or difficulties with the system, email or call Kyle Neeley, 

neeleyk@wustl.edu , 454-8270. 

E. Review Process 

All applications will be evaluated by two anonymous scientific reviewers as well as a 

patient advocate and scored according to scientific merit and accordance with the RFA. 

Terms of the Award: 

• Funds are for one year. It is expected that the Grantee will completely utilize the 

full amount of funding during the one-year term of the award. No-cost extensions 

of one year may be granted with the approval of the Breast Cancer Research 

Steering Committee. All unspent funds at the end of the grant period (with nocost 

extensions as applicable) will be returned. 

• All awards must have appropriate institutional regulatory approvals (SCC 

Protocol Review and Monitoring Committee, Human Research Protection Office, 

Animal Studies, Radiation Safety) before funds will be transferred. 

• An annual progress report will be required no later than 60 days following the end 

of the funding period and for the following 3-5 years to capture any subsequent 

grants or publications. 

• Indirect costs will not be awarded. 

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