Information - Kansas State University

Kansas State University
Department of Chemistry
This presentation will provide you with information
about some of the many different research topics
that we offer.
Feel free to take a virtual trip through our
Department (use the slide show option) and do not
hesitate to contact us if you have any questions or
comments.
Prof. Aakeröy: aakeroy@ksu.edu or 785-532 6096

Going to graduate School
How about Kansas State University

You can make new molecules...

Aufsicht
...or study their properties.

Several focus areas
Asymmetric catalysis
Biophysical chemistry
Drug design in theory
and practice
Structure and bonding
Bioanalytical chemistry
and chemical sensors
Materials science and
nanotechnology
Supramolecular chemistry and crystal engineering

Biological sensors
Electronic structure
Quantum chemistry
Chemical separation
Biophysical
chemistry
Ultrasensitive microscopy
Single-molecule spectroscopy

Professor Christine Aikens
Quantum chemistry
Application of electronic structure methods to:
Nanoparticles
Nanostructured materials
Complex intermetallics
Quasicrystals
To investigate:
Optical properties
Interparticle interactions
Growth mechanisms
Design and programming of
efficient algorithms in the
GAMESS program

Nanostructured Materials
Control over assembly of nanoparticles is
primary obstacle to bottom-up construction of
novel materials and devices
Goals:
•Understand the interactions between
nanoscale building blocks
•Achieve control over these interactions
•Elucidate how certain types of interactions
lead to specific target structures
Self-assembly of
colloidal crystals
Binary nanoparticle
superlattices
Shevchenko, E. V. et al.
Nature 2006, 439, 55.
Murray, C. B. et al. Science 1995, 270, 1335.
Aikens Group

Complex Intermetallics
Complex intermetallic icosahedral alloys
– Excellent long-range order but no periodicity
How do these structures form
Goals:
– Cluster-by-cluster
– Atom-by-atom
• Explain stability of gas-phase clusters
• Determine structural motifs in these clusters
• Examine the atom-by-atom growth mechanism
in order to determine its viability
icosahedral Zn-Mg-Dy
Aikens Group

Professor Viktor Chikan
Physical Chemistry and Material Chemistry
Research Interest
Physical chemistry of nanostructuresoptical,
electrical properties and
thermodynamics of doped quantum confined
semiconductor systems
Synthesis of Doped Nanostructures
Controlling the conductivity (carrier density, carrier
mobility) in quantum confined semiconductor devices is
important for future applications. We are developing
synthetic methods of creating doped quantum dots. In
addition, we are interested in doping intrinsically
anisotropic (such as GaSe quantum dots) and
extrinsically anisotropic quantum confined systems (e.g.
CdSe quantum rods).

Time-domain Terahertz Spectroscopy of Doped Nanostructures
1 THz = 300 µm = 33 cm -1 = 4.1 meV
Measuring the
conductivity of the
doped nanostructures is
challenging because of
the difficulty to
connecting them to
external circuitry.
Terahertz radiation
generated by an
ultrafast laser provides
a convenient way to
measure the frequency
dependant complex
conductivity of the
doped nanostructures.

Ultrafast Carrier Dynamics
(Time-resolved Terahertz Spectroscopy)
While Time-domain
Terahertz Spectroscopy
offers a way to probe the
equilibrium conductivity
of the doped system,
Time-resolved Terahertz
Spectroscopy provides a
way to measure the
transient conductivity in
doped quantum dots, p-
n junctions and 3D
quantum Wells.

Professor Christopher Culbertson
Bioanalytical Chemistry -
Separations, Microfluidics, and Cell Analysis
We are interested in
developing new separation
and sample handling
components for microfluidic
(Lab-on-a-Chip) devices and
then using these devices to
solve interesting bioanalytical
problems.
These devices may facilitate 1) the early diagnosis and successful
treatment of diseases like cancer, and 2) a better understanding
how complex organisms develop from single cells.

Prof. Christopher Culbertson
Buffer
Sample
Waste
5.08 cm
SW
High Efficiency Separations
3.0
2.5
D
E
S
G
Q
P
T
A
10mM Borate/50mM SDS w/ 10% i-PA
l = 11.84 cm; E sep = 740 V/cm
Single Cell
Analysis
2.0
1.5
1.0
0.5
N
C
Y
V
M I L
K
F
K
W
R
0.0
70
80
90
100
110 120 130
Elution time (sec)
140
150
160
170

Professor Dan Higgins
Analytical Chemistry, Materials Chemistry, Optical
Microscopy and Spectroscopy
Single Molecule Spectroscopy
Near-field Scanning Optical Microscopy (NSOM)

1. High Resolution Optical Microscopy Studies of
Liquid-Crystal/Polymer Composites
Multiphoton Excited Fluorescence Microscopy
Near-Field Optical Microscopy
Aluminu m
125 µm
Optical
Fiber
100 nm
Conventional
Fluorescence
Two Photon Excitation
Near Field
Far Field
Higgins Group
Detector

2.Polymer/LC Composites: Order LC Droplet Arrays and
Photorefractive Materials
NSOM Imaging: Photorefractive LCs
Multiphoton Excited Fluorescence:
Hexagonal LC Droplet Arrays
4 µm
Topography
Birefringence
Fluorescence
4 µm
Asymmetric Laser Beam Diffraction
Pu
Pr
2 µm
Hall and, Higgins, J. Phys. Chem, in press.
Higgins Group
Luther, Springer, Higgins, Chem. Mater., 2001, 13, 2281.

3. Organic Photovoltaics:
Self-Assembly of New Solar
Cell Materials
Dye/Polymer
Composites
O N O
N(CH 3
) 3
+
X-
Fluorescence
1200
1100
1000
900
Domain Organization
O
N
O
C 12 -PDI +
0
50
100
150
Polarization (degrees)
Higgins Higgins Group Group

Professor Takashi Ito
Analytical Chemistry (Chemical Sensing), Electrochemistry,
Self-Organized Nanostructural Materials, Nanofluidics
Our Research Interests:
1. Synthesize and characterize novel selforganized
nanostructural materials
with uniform domain morphologies.
2. Clarify molecular-level mass- and
charge-transport within the nanoscale
domains.
3. Apply these materials for chemical
sensing, separations and energy-related
technologies.

Preparation and Characterization of Nanoporous Materials
• Design and prepare monolithic materials comprising an array of
self-organized cylindrical nanopores with uniform pore sizes.
• Characterize the properties of nanopores using electrochemical,
spectroscopic and microscopic techniques.
Anodic nanoporous metal oxides
Block copolymers
Electrochemical
characterization
1) T. Ito, A. A. Audi, G. P. Dible Anal. Chem. 2006, 78, 7048.
2) Y. Li, H. C. Maire, T. Ito Langmuir 2007, 23, 12771.
3) Y. Li, T. Ito Langmuir 2008, 24, 8959.
4) H. C. Maire, S. Ibrahim, Y. Li, T. Ito Polymer 2009, 50, 2273.
5) D. M. N. T. Perera, T. Ito Analyst 2010, 135, 172.
6) F. Li, R. Diaz, T. Ito RSC Adv. 2011, 1, 1732.
7) S. Ibrahim, S. Nagasaka, D. S. Moore, D. A. Higgins, T. Ito ECS Trans. 2012, 41, 1.
8) B. Pandey, P. Thapa, D. A. Higgins, T. Ito Langmuir 2012, 28, 13705.

Applications of Nanoporous Materials
1. Fundamental Studies on Mass-
Transport within Nanodomains
• Single-molecule spectroscopy
(in collaboration with Prof. Higgins)
2. Chemical Sensing with
Cylindrical Nanodomains
• Uniform pore sizes and shapes
size-selective sensing media
• Controllable surface chemistry
chemically selective sensing media
1) K. H. Tran Ba, T. A. Everett, T. Ito, D. A. Higgins Phys.
Chem. Chem. Phys. 2011, 13, 1827.
2) A. W. Kirkeminde, T. Torres, T. Ito, D. A. Higgins J. Phys.
Chem. B 2011, 115, 12736.
3) S. C. Park, T. Ito, D. A. Higgins J. Phys. Chem. B in press.
4) K.-H. Tran-Ba, J. J. Finley, D. A. Higgins, T. Ito J. Phys.
Chem. Lett. 2012, 3, 1968.
1) Y. Li, T. Ito Anal. Chem. 2009, 81, 851.
2) S. Ibrahim, T. Ito Langmuir 2010, 26, 2119.
3) T. Ito, I. Grabowska, S. Ibrahim Trends Anal. Chem. 2010, 29, 225.
4) D. M. N. T Perera, B. Pandey, T. Ito Langmuir 2011, 27, 11111.
5) B. Pandey, K. H. Tran Ba, Y. Li, R. Diaz, T. Ito Electrochim. Acta
2011, 56, 10185.
6) F. Li, B. Pandey, T. Ito Langmuir, submitted.

Professor Jun Li
Analytical Chemistry and Materials Chemistry
Research Interest
The growth and characterization of nanowire
materials (carbon nanotubes/nanofibers, inorganic
semiconducting or metal nanowires), the fabrication
and integration of nanowire materials into solid-state
micro/nano- devices, and the development of novel
nanodevices (particular electronic devices) for
analytical and biomedical applications.
Goal
Our goal is to develop new biosensors and
nanobiotechnologies for environmental, security, and
biomedical applications through the innovation in
nanomaterials growth and device integration and
collaboration with industries and government
agencies.
Plasma Enhanced Chemical Vapor
Deposition
Graphite SWNT MWNT Carbon Nanofibers

Nanotechnology Platforms Based on
Vertically Aligned Nanowires
Mechanical
Electrical
Biomimetic Dry Adhesives
Electrical
MWCNT/CNF
Electrical
Ultrasensitve Nucleic
Acid Detection
E. Coli
Nanoscale IC Interconnects
Thermal &
Mechanical
Inorganic Nanowires
Electronic
Electrical
Ultrasensitive Immunosensor
Thermal Interface Materials
Vertical Nanoelectronics
and nanophotonics
Neural Electrical Interface

Fabrication of Carbon Nanofiber Nanoelectrode
Arrays for Biosensing
As-grown CNF arrays Inlaid CNF arrays in SiO 2
Micropatterned
2 mm
30 dies on a 4” wafer
50 mm
Nanopatterned
200 mm
A 3x3 microelectrode
5 mm
carbon nanofiber arrays
on each microelectrode
Nonpatterned
J. Li, et al, Nanoletters, 3(5), 597-602 (2003).
J. Li, et al, Appl. Phys. Lett., 82(15), 2491 (2003).
J. Koehne, et al., Clinic. Chem. 50:10, 1886 (2004).
500
nm

Professor Ryszard Jankowiak
Physical, biophysical, and analytical chemistry
Photosynthesis
Research
Cancer
Research
N1

The primary events of interest are excitation energy transfer and
charge separation, both of which involve arrays of interacting
chlorophyll molecules and other cofactors that are held in strategic
positions by protein scaffolding.
Photosynthesis Research
Solar energy driven
primary events of
photosynthesis; molecular
electronics…

Cancer Research
Understanding the activity of
carcinogens, structure of DNA
adducts, and development of
advanced biomonitoring
techniques
for cancer risk assessment…
Develop novel methods/devices for screening estrogen-derived DNA
adducts, conjugates, and metabolites in human samples
immunoaffinity biosensor columns with imaging capabilities…
innovative MAb-based biosensors on glass, polymer, and/or silicon wafer
substrates with multiple addressable patches on the surface designed and built
for detection of CEQ-derived biomarkers
Detection will be based on a novel “first-come-first-served” approach and
fluorescence based imaging. Human samples to be studied include: urine, serum,
and tissue extracts obtained from human breast and prostate cancer patients…

Professor Paul Smith
Biophysical chemistry
Co-solvent effects on peptides
and proteins.
Modeling of opioid peptides and
their receptors.
Computer simulation of the structure
and dynamics of peptides, proteins
and nucleic acids.

The general focus of the group is the study of the effects of solvent and
cosolvents on the structure and dynamics of biomolecules in solution. Our
main tool is molecular dynamics simulations which are used to provide
atomic level detail concerning the properties of these molecules.
Our current research is focused in several areas
Cosolvent Effects on Peptides and Proteins
Why do urea and gdmcl denature proteins
How does trifluoroethanol induce helix structure
What does the denatured state of a protein look like
Opioid peptides and delta-opioid receptor modeling
What does the delat-opioid receptor look like
What is the active conformation of receptor agonists
What is the conformational change of the receptor on activation
Improved force field parameters
How can we improve our ideas of how atoms/molecules interact

Opioid peptides and delta-opioid receptor
modeling
Opioids are small peptides that play a major role in
our response to pain. The design of improved and
non addictive new pain killing drugs depends on an
understanding of the interaction between opioids
and their receptor. The exact site of opioid peptide
binding to the receptor is unknown. We have
recently developed a model for the delta-opioid
receptor (see right) which can be used to probe the
interactions between potential drug molecules and
the receptor.
By simulating the conformational preferences
of known delta-opioid receptor agonists one
can speculate on the bioactive conformation
of the peptides required for receptor activation
(see left for Deltorphin I).

Organometallic chemistry
New catalysts
Nanoparticles
Environmental protection
Molecular magnets
Zeolite mimics
Supramolecular chemistry

Professor Christer Aakeröy
Supramolecular synthesis and structural chemistry
Fundamental crystal engineering
Design of functional solids
Supramolecular synthesis
Molecular sociology

Interactions between
molecules control...
Key steps in supramolecular synthesis
Recognition
…the bouquet of wine,...
…the ability of a drug to
block an enzyme,...
Binding
Organization
This needs to be achieved
without making or breaking
any covalent bonds!
We use hydrogen bonds and
halogen bonds as molecular
‘glue’ for linking different
building blocks into predictable
architectures.
Function
R
O
O
H
H
O
O
R
R
O
N
H
H
N
O
H
R
…and the formation of
thunder clouds.
R
H
N
H
O
O
H
N
H
R
H

S (mg/mL)
1. Supramolecular inorganic chemistry (NSF support)
L L
M
L L
L
M
L
M=Pt, Pd, Ni,Cu(I)
L
M
M=Ru, Ir, Rh, Fe, Co
L
L
L M L
L
L
Porous materials and
nanoparticles.
2-D
3-D
2. Supramolecular organic chemistry (NSF support)
(SR)
Ternary cocrystals
Molecular capsules
3. Pharmaceutical chemistry (Industry Support)
0.5000
0.4500
0.4000
0.3500
0.3000
Solubility studies of HMBA @ 24hrs
Why compounds fail or slow down in development
0.2500
0.2000
0.1500
0.1000
0.0500
We have shown that cocrystals
of anti-cancer agents
can improve properties such
as solubility.
0.0000
4,4-HMBA HMBA + Suc HMBA + Adip HMBA + Sub HMBA + Seb
API & Cocrystal
Aqueous solubility of the drug can be modulated!
The solubility can be increased or decreased
compared to that of the drug itself.

Professor Chris Levy
Organometallic chemistry and catalysis
Our primary interests are the
development of new stereospecific
catalysts for organic transformations and
polymerizations and the investigation of
organometallic structure and mechanism.
R 1 R 2
[O]
OH
R 1 R 2
We are creating new helical
transition metal catalysts for
the following asymmetric
transformations:
R 1 R 2
O
[O]
R 1 R 2
R 3 R 4
R 3
R 4
O
S [O] S
R 1 R 2 R 1 R 2

Some new helical complexes and their structures.
N
N
OHHO
NaOMe, 25ûC N N
+ FeCl 2 Fe
Toluene, EtOH O O
20h r.t.
HH
H H
H
N
OH
N
HO
+ ZnCl 2
NaOMe, 25ûC
N N
Zn
O O

Professor Eric Maatta
eam@ksu.edu
Synthetic Inorganic and Materials Chemistry
Polyoxometalate clusters
Multinuclear NMR studies
Metal-ligand multiple bonds
Transition metal catalysis
Hybrid materials
really big molecules

A couple of our favorites . . .
A soluble polystyrene incorporating a
redox-active polyoxometalate cluster
A nitrido-polyoxometalate:
[(Os VI N)P 2 W 17 O 61 ] 7-

Professor Emily McLaurin
Inorganic Chemistry and Materials Chemistry
Sensing of biological analytes
Heterostructures for catalysis
New materials for solar light harvesting
Energy transfer and charge transfer at interfaces

Material surfaces and interfaces
Surface chemistry plays a critical role
in the properties of nanomaterials.
Changing the material surface adjusts
the particle solubility, conductivity,
stability, and luminescence among
other properties.
Doped materials for ratiometric sensing
+ analyte
Synthesis of new transition
metal-doped semiconductor
nanomaterials allows for
exploration of new sensing
mechanisms using dopant
related properties. The dopant
also acts as a probe of the
semiconductor surface.

New materials for light harvesting and catalysis
Asymmetry
Materials that absorb a large part of
the solar spectrum are often easily
oxidized. Stability can be enhanced
using new structures and materials.
Charge separation in semiconductor
nanomaterials can be improved by
formation of hetero- and asymmetric
structures as well as alternative
morphologies.
New morphologies
Heterostructures
Examination of energy and charge transfer
processes affecting hybrid organic-semiconductor
and metal-semiconductor systems can improve
solar conversion and storage efficiencies.

Total synthesis
Proteins and peptides
Anti-cancer drugs
Host-guest chemistry
Regioselective catalysis
Ferroelastic materials

Professor Stefan Bossmann
Organic, Bioinorganic and Materials Chemistry
Stem Cell
Identification
Optical Tomography
Tumor Imaging

Professor Stefan Bossmann
Organic, Bioinorganic and Materials Chemistry
Synthesis of Fe(0)-Nanoparticles for Tumor Imaging,
Hyperthermia Treatment of Cancer and Catalytic Applications

Professor Stefan Bossmann
Organic, Bioinorganic and Materials Chemistry
Stem Cells and Defensive Cells take up of Fe(0)-nanoparticles and
transport them to tumors thus permitting cell-based cancer therapy.
A: Melanoma in a Black Mouse; B: Stem Cells (red) travel to the
location of tumors/metastases
This work is performed in close collaboration with Prof. Dr. Deryl L.
Troyer, Department of Anatomy&Physiology

Professor Mark Hollingsworth
Physical-Organic and Solid-State Organic Chemistry

Probing the elastic properties of materials - studies of
ferroelastic and ferroelectric domain switching
Domain switching is an important phenomenon in
technological devices, but it also can be used as a
tool to understand how elastic properties of
crystals are affected by internal molecular
structures, impurities and defect structures.
2,10-Undecanedione/urea crystals contain
ferroelastically distorted domains that are
twinned across two types of boundaries
to give as many as twelve sectors.
Pure crystals of this material
undergo irreversible (plastic)
domain reorientation (above),
but 2-undecanone impurities
can make this process elastic.
(See videos on the next page.)
before stress after stress
As a complement to SWBXT,
birefringence mapping using the
Metripol microscope gives both
indicatrix orientation (upper) and
Synchrotron white beam X-ray
topography (SWBXT) images
taken before and after stress for
optical retardation (lower) and
reveals disorder both within and
between domains, especially at
crystals containing 10% (top), 14% boundaries that show epitaxial
(middle) and 18% 2-undecanone mismatches.
(bottom) show that impurities
unpin stressed defect sites and
make domain switching reversible.
By generating a large series of ferroelastic inclusion compounds that are closely related to each other,
and then comparing domain switching in these crystals as a function of impurities, it is possible to show
that the impurities control the dynamics and reversibility of domain switching by breaking up cooperative
hydrogen bonding networks and unpinning stressed sites in these crystals.

Ferroelectric domain switching in inclusion
compounds of tetra-t-butylcalix[4]arene
O
N
O
-
+
+
N
O -
Host structure
In an electric field, the guests rotate
about the pseudo-fourfold axis of the host
X
X
X
Y
X
Y
Z
Y
X
Z(X')
X
Which of the above guests could show
ferroelectric domain switching

Professor Duy H. Hua
Synthesis and Bio-evaluation of Natural and Unnatural Products,
Design of Enzyme Inhibitors, and Syntheses of Beltenes and
Nanomaterials
Anti-cancer agents targeting
Gap junction intercellular
communication
Development of new stereo-selective reactions
Synthesis of nanogels for selective drug delivery

Two major research projects are being carried out in our
group, and they are: synthesis, mechanism, and
bioevaluation of biologically active compounds and
syntheses and applications of beltenes and nanomaterials.
Bioactive
Compounds
O
Biophysical Analyses
Releasing of blood vessel
H
H
O
O
CO 2 H
Myriceric Acid A
for release of vasospasm
OH
OH
O
H
O
O
N
CH 3
NH 2
N
N
N
A Tricyclic Pyrone Adenine
for disaggregation of A42
oligomers
Surface Plasmon Resonance of
A and CP2
RO
Duy H. Hua
R'HN
OAr
N
Quinolines for gap junction
intercellular communication
Gap junction channel and PQ1

Duy H. Hua
R 1 R 2 R 2
Synthetic targets
R 1 R 2 R 2
R 2
R 1 R 2
R 1
R 1
R 2 R 1
R 2
R 1
R 1 R 2
R 2
R 1 [12]Cyclacenes
R1
R 2 R 2
R 1 R 1
10.64 Å
9.71 Å
Armchair Carbon nanotube
Atomic force microscopic
images of functionalized
carbon nanotubes
1
H- 15 N-HSQC spectrum of A40
peptide
Bar is 0.5 mm.

Professor Ping Li
Chemical Biology/Bioorganic Chemistry
Research Interests
Use synthetic organic chemistry
and molecular biology as major
tools to study and manipulate
biologically
important
enzymes/proteins. Currently, I
have four projects in my lab.

1. Studies of ghrelin acylation by ghrelin
O-acyltransferse (GOAT).
GOAT was recently discovered 1-2 as a potential drug target
for curing obesity. We will investigate its molecular
mechanisms and design effective inhibitors to it.
1. Gutierrez, J. A.; Solenberg, P. J.; Perkins, D. R.; Willency, J. A.; Knierman, M. D.; Jin, Z.;
Witcher, D. R.; Luo, S.; Onyia, J. E.; Hale, J. E. Proc. Natl. Acad. Sci. USA 2008, 105, 6320.
2. Yang, J.; Brown, M. S.; Liang, G.; Grishin, N. V.; Goldstein, J. L. Cell 2008, 132, 387.
Commercial products made of PHA
2. Mechanistic studies of polyhydroxyalkonate
(PHA) biosynthesis.
Biodegradable plastic PHAs can substitute oil-based
plastics that are non-biodegradable. Our ultimate
goal is to understand mechanisms of proteins
involved in PHA biosynthesis and to engineer them
to produce PHAs in an economically competitive
fashion, which will help to protect our environment
and save energy.

3. Investigation of peptidoglycan glycosyltransferases
(PGTs) in peptidoglycan
biosynthesis.
PGT catalyze the final step of polymerizing Lipid II to
form the nascent bacterial wall. Because their function
is unique and essential for bacterial survival, PGTs
have been the major target of clinically used
antibiotics. Our goals are to understand the
mechanism of substrate recognition by PGTs, to
develop a model that can predict interactions between
PGTs and substrate, and to design novel inhibitors to
PGTs.
4. Site-specific protein labeling using SNAP tag.
Selective labeling of proteins has become an essential tool to
visualize and characterize biological activities inside living cells.
The SNAP tag was first introduced by Kai Johnsson using a human
O 6 -alkylguanine-DNA alkyltransferase (hAGT), which transfers the
alkyl group from its substrate, O 6 -alkylguanine-DNA to one of its
cysteine residues. Our goals are to develop novel small molecule
probes for specific labeling and apply this technology for detection
of protein-protein interactions.

Professor Ryan J. Rafferty
Organic Chemistry & Chemical Biology
Total Synthesis
Development of Selective
Drug Delivery Systems
Drug Discovery
and Evaluation
Structurally Remodeling for Library Construction
Blood-Brain Barrier Penetration
Investigation, Enhancement, and Therapeutic

Total Synthesis, Structurally Remodeling for Library
Construction, Drug Discovery and Evaluation
•Total Synthesis Campaigns of Biologically
Interesting Compounds
•Structural Remodeling of Natural Products
and Complex Intermediates
•Library Construction
•Screening Campaigns of Synthesized
Compounds
•Biochemical and Molecular Biology
•Medicinal Chemistry
•Discovery of New Drug Candidates
Rafferty Research Group

Blood-Brain Barrier Penetration
Investigation, Enhancement, and Therapeutic
•Synthesis of Chemical Library Probing
Varying Chemo-physical Properties via
Ring Closing Metathesis, Diels-Alder &
Peripheral Modification reactions
•Evaluation of Compounds Upon Blood
Brain Penetration
•Library Construction
•Elaboration of Scaffolds and Evaluation against various diseases
Nature Reviews Drug Discovery 2007, 6, 650-661
Rafferty Research Group

Development of Selective Drug Delivery Systems
•Targeting Folate Receptors due to Over-
Expression within Cancers and Acidic
Microenvironments
•Enhancement of Drugs to Reduce Off-Target
Side Effects
•Evaluation of system in vitro/vivo
Rafferty Research Group

A few more reasons to consider Graduate
studies in Chemistry at Kansas State:
• Competitive stipends.
• An expanding and well-funded Department.
• First-rate research in inorganic, organic,
physical, analytical, materials, and biological
chemistry.
• Friendly and helpful staff and faculty.
• Our graduate students have successful careers
(see next few pages for some examples)!

Gregory Roman (Ph. D.
2006)
Assistant Professor
Bryn Mawr College
Andrew Moran (Ph.D. 2002)
Assistant Professor
Univ. of North Carolina, Chapel Hill
Nate Schultheiss (Ph. D. 2007)
Halliburton
(Fulbright Fellow with Jean-
Marie Lehn in 2008)
Gustavo Seabra (Ph.D. 2005)
Professor Adjunto
Universidade Federal de
Pernambuco, Brazil
Dr. Joaquin Urbina
Ph. D. 2005
Professor
University of Belize
Dr. Michelle Smith
Ph. D. 2009
GlaxoSmithKline, UK

QuickTime and a
decompre sor
are n eded to s e this picture.
Tom Everett (Ph. D. 2010)
Postdoc
Univ. of Missouri
Dmytro Demydov (Ph. D. 2006)
Research Assistant Professor
Univ. of Arkansas
Safiyyah Forbes (Ph.D. 2010)
Assistant Professor
Monmouth College, Illinois
Johanna Haggstrom (Ph. D. 2007)
Halliburton in Lawton, OK
Dambar Hamal (Ph.D. 2009)
Postdoc
Univ. of Connecticut
Pubudu Gamage (Ph. D. 2009)
Postdoc
Univ. of Wyoming
Yen-Ting Kuo (Ph. D. 2010)
Postdoc
Univ. of Michigan
Jeff Lange (Ph. D. 2009)
Staff Scientist
Stowers Institute for Medical
Research in Kansas City

We also have a beautiful Campus..
Anderson Hall
Student Union
The Art Museum
The Farrel library
The Hale library

...with over 20,000 students.

KSU is located in Manhattan...

…in the Flint
Hills, North-
East Kansas.

If you need more information about
Chemistry at Kansas State or if you
want to receive an application
package….
Contact:
Prof. Christer Aakeröy (aakeroy@ksu.edu)
or
Mary Dooley (mldooley@ksu.edu)

Welcome to Kansas State!
http://www.ksu.edu/chem/