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Vaccine

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Clinical Significance<br />

• In a patient both BAbs and NAbs can lead<br />

to loss of efficacy and/or negatively impact<br />

safety, therefore both may be clinically<br />

important<br />

• NAbs may be more effective in directly<br />

impacting efficacy<br />

– IL-2 and IFN-b higher titers of NAbs are<br />

associated with loss of efficacy

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