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Clinical Significance<br />
• In a patient both BAbs and NAbs can lead<br />
to loss of efficacy and/or negatively impact<br />
safety, therefore both may be clinically<br />
important<br />
• NAbs may be more effective in directly<br />
impacting efficacy<br />
– IL-2 and IFN-b higher titers of NAbs are<br />
associated with loss of efficacy