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Vaccine

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Seasonal Influenza <strong>Vaccine</strong>s<br />

Potency Measurements<br />

� Potency measurements require reference immunoreagents<br />

� Type/Subtype matched antisera<br />

� Type/Subtype matched antigen (virus) HA reference standard<br />

� SRID assay features<br />

� Antiserum is incorporated into agarose matrix<br />

� Samples are solubilized with detergent and allowed to diffuse<br />

into the agarose<br />

� A zone of immunoprecipitin forms where the antibody-antigen<br />

complex is no longer soluble

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