Protein Aggregation and Immunogenicity

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Any substance can be rendered immunogenic! Soluble molecules: B-cell tolerance Repetitive epitopes on polymeric or particulate drug carriers: B-cell stimulation Prerequisites: • At least 10-20 repetitive epitopes () • Inter-epitope distance between 5-10 nm Jiskoot et al., Pharm Res 26: 1303-1314 (2009)
B-cell stimulation by epitope arrays Wouldn’t protein aggregates act similarly = protein molecule And particles with adsorbed proteins = protein molecule Poliovirus FMD Virus
Page 1 and 2: Protein Aggregation and Immunogenic
Page 3 and 4: Immunogenicity - definition T cell
Page 5 and 6: Clinical consequences of immunogeni
Page 7 and 8: Factors influencing immunogenicity
Page 9 and 10: Factors influencing immunogenicity
Page 11 and 12: Aggregates and immunogenicity: clin
Page 13 and 14: Immunogenicity: the formulation mat
Page 15 and 16: Immunogenicity: the formulation mat
Page 17: Fate of auto-reactive B cells after
Page 21 and 22: Protein immunogenicity - our curren
Page 23 and 24: Tools to predict immunogenicity •
Page 25 and 26: Human interferon-a2 immune tolerant
Page 27 and 28: Only “native like” aggregates i
Page 29 and 30: Memory study - injection and blood
Page 31 and 32: Antibody response against aggregate
Page 33 and 34: Aggregated rhIFNb does not act as a
Page 35 and 36: Conclusions from studies with trans
Page 37 and 38: Protein immunogenicity - wrap up St
Page 39 and 40: Thank you ! Hope to see you again a
Page 41 and 42: IgG titer Transgenic immune toleran
Page 43: Switching from IFNβ-1b to IFNβ-1a

Protein Aggregation and Immunogenicity

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