Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
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Tools to predict immunogenicity<br />
• Process / formulation characterization<br />
(including aggregates, particles…)<br />
• Animal studies - transgenics<br />
• In silico B-cell prediction<br />
• In silico T-cell prediction<br />
• T-cell epitope screening assays<br />
• T-cell activation assays<br />
THE MAIN CHALLENGE NOW:<br />
• Clinical How studies to bridge the gap<br />
• Postmarketing surveillance / pharmacovigilance
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