Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
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Human interferon-a2 immune tolerant mice<br />
IgG Titer<br />
100000<br />
rhIFN a2b<br />
ovalbumin<br />
10000<br />
1000<br />
Titers on<br />
day 22<br />
100<br />
10<br />
Wildtypes<br />
Transgenics<br />
Week 1 Week 2 Week 3<br />
Day 1 Day 8<br />
Day 15<br />
Day 22<br />
5 μg / injection<br />
Blood sampling<br />
(s.c. or i.p.)