Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
Protein Aggregation and Immunogenicity
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<strong>Protein</strong> immunogenicity – our current knowledge<br />
• Practically all rh therapeutic proteins <strong>and</strong> antibodies are<br />
immunogenic<br />
• We do not exactly know why<br />
• Besides patient- <strong>and</strong> treatment-related factors,<br />
formulation <strong>and</strong> product quality are important<br />
• Aggregates are suspicious as risk factors<br />
• We do not know which aggregates<br />
• We do not know the critical aggregate dose
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