Protein Aggregation and Immunogenicity

More documents

Recommendations

Info

Antibody response against aggregated rhIFNa2a is T cell dependent – in both wildtype <strong>and</strong> transgenic mice Anti-rhIFNa2a antibody titers after a 3-week injection protocol Pneumovax (TI antigen) – CD4 + T cells blocked + not blocked Sauerborn et al. (2010) Manuscript in preparation
Aggregated rhIFNb does not act as an adjuvant for native rhIFNa2a in transgenic mice Anti-rhIFNa2a antibody titers after a 3-week injection protocol rhIFNb Sauerborn et al. (2010) Manuscript in preparation
Page 1 and 2: Protein Aggregation and Immunogenic
Page 3 and 4: Immunogenicity - definition T cell
Page 5 and 6: Clinical consequences of immunogeni
Page 7 and 8: Factors influencing immunogenicity
Page 9 and 10: Factors influencing immunogenicity
Page 11 and 12: Aggregates and immunogenicity: clin
Page 13 and 14: Immunogenicity: the formulation mat
Page 15 and 16: Immunogenicity: the formulation mat
Page 17 and 18: Fate of auto-reactive B cells after
Page 19 and 20: B-cell stimulation by epitope array
Page 21 and 22: Protein immunogenicity - our curren
Page 23 and 24: Tools to predict immunogenicity •
Page 25 and 26: Human interferon-a2 immune tolerant
Page 27 and 28: Only “native like” aggregates i
Page 29 and 30: Memory study - injection and blood
Page 31: Antibody response against aggregate
Page 35 and 36: Conclusions from studies with trans
Page 37 and 38: Protein immunogenicity - wrap up St
Page 39 and 40: Thank you ! Hope to see you again a
Page 41 and 42: IgG titer Transgenic immune toleran
Page 43: Switching from IFNβ-1b to IFNβ-1a

Protein Aggregation and Immunogenicity

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?