PROTEIN TRANSDUCTION: - Moores Cancer Center

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UCSD Cancer Center Foundation PRESIDENT OF THE FOUNDATION BOARD Cinda K. Lucas * OFFICERS Gordon P. Boerner * Marilynn Boesky * Howard I. Cohen * William T. Comer, Ph.D. * Frank M. Goldberg * Charles F. Gorder Sr., Esq. * Mary Rand Taylor * John McDonnell * BOARD OF DIRECTORS J. Samuel Armstrong, IV Terry Ash Kathryn A. Bernert, Esq. Howard C. Birndorf Sophie Brody Deborah J. Case Carol L. Chang Jay de Groot Charles Faith Yehudi Gaffen Howard Goldfeder* Donald W.Grimm Andre R. Horn Ernest Huang, Ph.D. Al Hugo-Martinez Jacqueline Johnson, Ph.D. Maurice C. Kaplan, Esq. * Jerome S. Katzin, Esq. * Jeffrey Lipinsky George L. Liggins, M.P.H., Ph.D. Joany Mosher Henry L. Nordhoff Carrie O’Brien Anne S. Otterson John W. Otterson, II Cynthia Polak Kenneth D. Polin, Esq. ADVISORY BOARD John R. Bonn, Esq. Diane Clarke Lois J. Crandell Audrey S. Geisel George L. Gildred Irwin Jacobs, Ph.D. Richard Levi Art Lujan Marianne McDonald, Ph.D. John H. Moxley III, M.D. Peter Preuss Clayton D. Pruett Ruth L. Schulman John Walton Walter Zable EX OFFICIO MEMBERS Robert C. Dynes, Ph.D. Edward W. Holmes, M.D. Robert Horsman Katherine Kennedy Sam Iacobellis, Ph.D. Esther R. Nahama Tom Nielsen Rebecca Newman INTERIM DIRECTOR, MOORES UCSD CANCER CENTER Gordon Gill, M.D. DEPUTY DIRECTOR, CLINICAL OPERATIONS David W. Easter, M.D. DEPUTY DIRECTOR, RESEARCH OPERATIONS Thomas J. Kipps, M.D., Ph.D. ASSOCIATE DIRECTOR FOR ADMINISTRATION Ira S. Goodman DIRECTOR OF DEVELOPMENT Sarah Godfrey ASSISTANT DIRECTOR OF DEVELOPMENT Cheryl D. Coate DEVELOPMENT ASSISTANTS Christa Collins Maryann Lapthorn Jennifer Mann * Officers and Members of the Executive Committee Moores UCSD Cancer Center News is a publication of the UCSD Cancer Center Foundation. Comments are welcome. UCSD Cancer Center Foundation 9500 Gilman Drive MC 0658 La Jolla, CA 92093-0658 (858) 822-0022 Executive Editor: Sarah Godfrey • Editor: Nancy Stringer Contributing Writers: Cheryl D. Coate, Sarah Godfrey, Nancy Stringer • Cover Photo: Dave Siccardi • Design: Janice Gordon Message from the Director As many of you may know, at the end of last year Dr. David Tarin stepped down as director of the Cancer Center to return full time to his research, teaching and clinical activities at UCSD. At that time, I was named as the interim director to maintain the Center’s forward momentum, and to continue its operations in a seamless fashion while the university conducts an international search for Dr. Tarin’s successor. It is an honor to serve as interim director of the Cancer Center, an organization I’ve been a part of since its founding in 1979. My UCSD roots go back even further. I’ve been a member of the UCSD faculty since 1969 when the School of Medicine was in its infancy. In those early days, there were no buildings on our medical school campus! We rented space at the Salk Institute, where we conducted research and went about the business of organizing the curriculum and planning the facilities for a brand new school. That was an extraordinarily exciting time and, in many ways, is similar to the excitement and energy all of us who are involved in cancer feel with the new Cancer Center facility coming to life. As the building takes shape, it acts as a catalyst to focus our efforts on major decisions that will impact the future of the Center. One of the most important decisions is the recruitment of a permanent director, and there is good news on this front. UCSD has assembled a stellar search committee that is actively interviewing candidates, all of whom are nationally prominent figures in the cancer field. We are pleased both with the number of candidates who have expressed interest in coming here, and with the quality of the candidates. As you might imagine, the recruitment process for such an important position is lengthy, but we hope to be able to announce a new director later this year. In the interim, the leadership and members of the Cancer Center are engaged in an internal evaluation process, looking at our current strengths and identifying areas to expand and enhance. Out of this process will emerge our strategic goals — an important aspect of our transition to the new Cancer Center building, scheduled to open in Fall 2004. Another area of activity as we plan for occupancy of the new facility is that of continuing to build and strengthen our clinical programs and our clinical research. In line with that, in this issue Cancer Center News 2
of the newsletter, on page 9, we introduce three new members of our Cancer Center family — clinical counselor Cynthia Sava, medical oncologist Lakshmi Vemuri, and cancer pharmacist Susan Wilson. In future issues we will bring you news of additional recruitments of clinicians with expertise in clinical research, particularly of innovative therapies. We are continuing to actively recruit to enhance our ability to translate new discoveries into more effective therapies. To better understand the importance of clinical research in our ongoing efforts to improve care for patients, I hope you will read the feature article about cancer vaccines on page 6. This article showcases exciting clinical research under way now at the Cancer Center that may lead to improved care for lymphoma patients. Clinical research and, ultimately, new standards of clinical care are founded upon basic science discoveries. Our cover story focuses on an intriguing new field of basic research called protein transduction, which is generating excitement among scientists around the world and holds tremendous promise for a broad range of clinical applications. We hope you enjoy learning about new developments at the Cancer Center as much as we enjoy sharing them with you. Sincerely, Gordon Gill, M.D. Interim Director, Moores UCSD Cancer Center Introducing…Gordon Gill, M.D. Adistinguished physicianresearcher, Dr. Gordon Gill has been a member of the UCSD faculty for 34 years. During his tenure at UCSD, he has served as chief of the Division of Endocrinology and Metabolism in the Department of Medicine (1971-95) and was associate chair for scientific affairs in the Department of Medicine (1992-95). Most recently he served as Dean for Scientific Affairs for the School of Medicine. He received his undergraduate and medical degrees from Vanderbilt University. After serving a residency and a National Institutes of Health post-doctoral fellowship at Yale-New Haven Hospital, he joined the UCSD faculty during the first year it taught medical students. IN THIS ISSUE 4 Cover Story: Protein Transduction 6 Cancer Vaccines 7 Know Your Breast Cancer Risk 8 Construction Update 9 New Clinical Staff 10 Development News 12 The Last Word Dr. Gill has served on numerous scientific boards and the editorial boards of many professional journals. Since 1995 he has been an associate editor of Cecil’s Textbook of Medicine. He is also a fellow of the American Academy of Arts and Sciences, and is a recipient of Research Career Development and MERIT awards from the NIH. His research has often focused on molecular abnormalities leading to malignant transformation, and his clinical practice in internal medicine and endocrinology has included a special interest in thyroid cancer and endocrine tumors. He holds a research grant from the NIH that is in its 36th year of continual funding, a rare accomplishment among scientists. ON THE COVER: The two cells, shown in red, illustrate the power of protein transduction to change the biology of human cells. In the laboratory, two types of the same protein, known to alter membrane architecture, were delivered into the cell membranes. In the top panel, the protein contained an inactivating mutation and the cell surface remained smooth. In the bottom panel, using a version containing an activating mutation, spikes appeared within 10 minutes in more than 95 percent of the cells. 3 Cancer Center News
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Page 7 and 8: Jerry Hermesch: REGAINING HIS FUTUR
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PROTEIN TRANSDUCTION: - Moores Cancer Center

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