Matzinger Oscar Date of birth
Matzinger Oscar Date of birth
Matzinger Oscar Date of birth
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Curriculum Vitae<br />
1. General information<br />
Name:<br />
<strong>Matzinger</strong> <strong>Oscar</strong><br />
<strong>Date</strong> <strong>of</strong> <strong>birth</strong>: 07.12.1970<br />
Nationality/Origin:<br />
Swiss/Zurich<br />
Family status:<br />
Married to Carole <strong>Matzinger</strong>-Besson<br />
Children: Inès, 19.08.08 Robin, 27.01.2011<br />
Private address:<br />
Pr<strong>of</strong>essional address:<br />
Rue du Midi 19, 1800 Vevey, Switzerland<br />
+41 79 541.75.10 <strong>Oscar</strong>.<strong>Matzinger</strong>@gmail.com<br />
Service de radio-oncologie, CHUV 1011 Lausanne, Switzerland<br />
+41 79 556.48.21 <strong>Oscar</strong>.<strong>Matzinger</strong>@chuv.ch<br />
Language: Bilingual: French & (Swiss-) German<br />
Spoken & Written: English<br />
2. Academic titles<br />
• Thesis in medicine (2002), University <strong>of</strong> Lausanne, Pr<strong>of</strong>. Luc Tappy<br />
“Effects <strong>of</strong> fatty acids on exercise plus insulin-induced glucose utilization in trained and sedentary subjects”<br />
• Board Certified (FMH) in radiation-oncology (2007)<br />
• Privat-Docent & Senior lecturer (“Privat Docent & Maître d’enseignement et de recherche”) (2011), University <strong>of</strong><br />
Lausanne.<br />
3. Pre-graduate<br />
• Medical school at University <strong>of</strong> Lausanne (1992 – 1998)<br />
• Graduation 1998<br />
4. Post-graduate<br />
a. Before Board Certification<br />
4.1999 – 9.2000 Resident, institute <strong>of</strong> physiology, University <strong>of</strong> Lausanne<br />
Pr<strong>of</strong> Eric Jécquier & Luc Tappy<br />
10.2000 – 3.2001 Resident, department <strong>of</strong> internal medicine, CHUV - Lausanne<br />
Pr<strong>of</strong> Pascal Nicod & Gérard Weber.<br />
4.2001 – 9.2001 Resident, department <strong>of</strong> medical oncology, CHUV<br />
Pr<strong>of</strong> Serge Leyvraz<br />
10.2001 – 9.2002 Resident, department <strong>of</strong> radiology, CHUV<br />
Pr<strong>of</strong> Pierre Schnyder<br />
10.2002 – 3.2005 Resident, department <strong>of</strong> radiation oncology, CHUV<br />
Pr<strong>of</strong> René-Olivier Miriman<strong>of</strong>f<br />
4.2005 – 3.2006 Resident, department <strong>of</strong> radiation oncology, Inselspital - Bern<br />
Pr<strong>of</strong> Richard Greiner<br />
4.2006 –12.2006 Deputy-Chief Resident (chef de clinique adjoint), department <strong>of</strong> radiation oncology, Inselspital<br />
Pr<strong>of</strong> Richard Greiner & Daniel Aebersold<br />
b. After Board Certification<br />
1.2007 – 3.2008 Chief Resident (“chef de Clinique”), in charge <strong>of</strong> H&N and lung cancer, melanoma and<br />
sarcoma, department <strong>of</strong> radiation oncology, CHUV, Pr<strong>of</strong> René-Olivier Miriman<strong>of</strong>f<br />
4.2008 – 3.2009 Radiotherapy Quality Assurance Fellow & Clinical research physician (CRP), European<br />
Organisation <strong>of</strong> Research in Treatment <strong>of</strong> Cancer (EORTC), Brussels<br />
4.2009 – 12.2009 Chief Resident, in charge <strong>of</strong> GI and lung cancer, melanoma, and sarcoma, department <strong>of</strong><br />
radiation oncology, CHUV, Pr<strong>of</strong> René-Olivier Miriman<strong>of</strong>f<br />
1.2010 – 3.2011 Associate physician (“médecin associé”), in charge <strong>of</strong> GI and lung cancer, melanoma, and<br />
sarcoma, department <strong>of</strong> radiation oncology, CHUV, Pr<strong>of</strong> René-Olivier Miriman<strong>of</strong>f<br />
4.2011 – actual Senior physician (“médecin adjoint”), in charge <strong>of</strong> GI and lung cancer, melanoma, and sarcoma,<br />
department <strong>of</strong> radiation oncology, CHUV, Pr<strong>of</strong> René-Olivier Miriman<strong>of</strong>f & Pr<strong>of</strong> Jean Bourhis<br />
6.2012 – 10.2012 Acting head <strong>of</strong> radiation-oncology department, CHUV<br />
As <strong>of</strong> 2013<br />
As <strong>of</strong> 2016<br />
Designated Head <strong>of</strong> department, Radiation Oncology department, Hospital <strong>of</strong> Riviera, Vevey<br />
Designated Head <strong>of</strong> department, department <strong>of</strong> medical oncology and radiation oncology,<br />
Hospital <strong>of</strong> Rennaz
2<br />
5. Teaching<br />
2004 – actual Bedside teaching, university <strong>of</strong> Lausanne<br />
2005 – 2006 Participation in pre- and post-graduate teaching, department <strong>of</strong> radiation oncology, Inselspital<br />
2004 – actual Participation in pre-graduate teaching, radiation oncology department CHUV<br />
2004 – actual Participation post-graduate teaching, oncology & radiation-oncology department, CHUV<br />
2010 – actual In charge <strong>of</strong> the oncology teaching to the radiology and radiation oncology technologist school<br />
<strong>of</strong> Lausanne (“école HES Lausanne”)<br />
2010 – actual In charge <strong>of</strong> the « Journal Club » radiation oncology department, CHUV<br />
2010 – actual Formal teaching to medical students, University <strong>of</strong> Lausanne:<br />
• Module B3.2: Introduction to thoracic cancer<br />
• Module M1.3: Radiotherapy for lung cancer<br />
• Module M 2.5: Multidisciplinary lesson on colo-rectal cancer<br />
2011 – actual PD lessons: Radiation oncology treatment in thoracic and digestive cancer<br />
6. Management<br />
Former <strong>of</strong>ficer (premier-lieutenant), Swiss army (artillery)<br />
2004 – 2007 Vice president and COO, Swiss association <strong>of</strong> medical residents (ASMAC; 20 ≈ employees)<br />
2010 Management course for management position <strong>of</strong> the CHUV<br />
2010 – actual Complete reorganisation <strong>of</strong> the workflow, radiation oncology department, CHUV<br />
2010 – actual Creation <strong>of</strong> the business plan & medical project leader <strong>of</strong> the future department <strong>of</strong> radiation<br />
oncology, hospital <strong>of</strong> Riviera, Vevey<br />
2010 – actual Medical project leader <strong>of</strong> the future medical and radiation oncology department <strong>of</strong> the future<br />
hospital <strong>of</strong> Rennaz<br />
8.2011 – 3.2012 Academic supervisor <strong>of</strong> the radiation oncology department <strong>of</strong> Sion (clinical supervision;<br />
workflow analysis & improvement; equipment adequacy analysis)<br />
7. Award<br />
03.2010 Label FBM (faculty <strong>of</strong> biology and medicine, Lausanne) 2010 award:<br />
« Investigator-in-training award in clinical sciences ».<br />
8. Medical & scientific board activity<br />
2000 – 2004 Member <strong>of</strong> the board <strong>of</strong> the Swiss association <strong>of</strong> medical interns (ASMAC/VSAO)<br />
2002 – 2004 President <strong>of</strong> ASMAV (ASMAC, section Vaud)<br />
2000 – 2007 Delegate at the medical chamber <strong>of</strong> FMH<br />
2004 – 2007 Vice-president ASMAC/VSAO<br />
2007 – actual Executive board member SASRO (Scientific Association <strong>of</strong> Swiss Radiation Oncology), in<br />
charge <strong>of</strong> communication<br />
2008 – actual Executive board member SWITRO SWITRO (Swiss trials in Radiation Oncology), in charge <strong>of</strong><br />
implementation <strong>of</strong> QA programs in Swiss trials (SAKK & SASRO)<br />
2010 – actual Executive board member & secretary <strong>of</strong> SRO (Swiss society <strong>of</strong> radiation oncology)<br />
2010 – actual Board member for federal examination in radiation oncology<br />
2011 – actual Expert for federal examination in radiation oncology<br />
2008 – actual Chairman Gastro-intestinal working party EORTC Radiation Oncology Group<br />
2008 – actual Steering committee member <strong>of</strong> the « EORTC - Radio Oncology Group (ROG) »<br />
2008 – actual Executive board member <strong>of</strong> the « EORTC (ROG) Quality Assurance group »<br />
2010 – actual Executive board member ARRAD (Association Romande de Radioprotection)<br />
2011 – actual Representative <strong>of</strong> the CHUV in the « Swiss Proton Task Force ».<br />
2009 – actual Reviewer in: « Lancet Oncology »; « International Journal <strong>of</strong> Radiation Oncology Biology and<br />
Physics » « Radiotherapy & Oncology »; « Lung Cancer »; « Case reports in medicine »;<br />
« Melanoma research »; « Rare Tumors »; « World Journal <strong>of</strong> Surgical Oncology »<br />
2011 – actual Clinical protocol peer-reviewer for: « Institut National du Cancer – INCa (France) »; « Nova<br />
Scotia Health Research Foundation »<br />
9. Membership scientific societies<br />
2008 – actual EORTC groups: RT & Lung & GI & H&N<br />
2008 – actual SAKK groups: RT & Lung & GI<br />
2003 – actual ESTRO (European Society for Therapeutic Radiology and Oncology)<br />
2010 – actual ASTRO (American Society for Therapeutic Radiology and Oncology)
3<br />
10. Research activity<br />
GCP Certification, level 3 (Swiss medic recognition: 27.10.2011)<br />
a) Clinical research:<br />
Strong clinical research activity in the frame <strong>of</strong> EORTC; SAKK and local protocols.<br />
Main focus:<br />
• GI cancer (anal cancer; gastric cancer)<br />
• Lung cancer<br />
• Quality assurance in clinical trials<br />
Principal investigator:<br />
- PARADAC: pooled analysis <strong>of</strong> all phase II & III randomised trials in anal cancer (EORTC, UKCCR,<br />
RTOG, SWOG, FNLCC). Publication Q1 2013<br />
- Phase II multicentric trial (Lausanne, Geneva, Sion): “Concomitant intensity-modulated radiotherapy<br />
combined to capecitabine, mitomycin, and panitumumab in patients with stage II-IIIB squamous-cell<br />
carcinoma <strong>of</strong> the anal canal”. Approval <strong>of</strong> ethic committee and Swiss Medic. Start Q4 2012<br />
Co – Principal investigator:<br />
- Co-author <strong>of</strong> a multicentric phase IB trial in gastric cancer (Lausanne; St-Gall): “Traitement de<br />
cetuximab en combinaison avec une radiothérapie locale et une chimiothérapie périopératoire dans le<br />
cancer gastrique localement avancé et résécable”. Study started Q3 2012<br />
- Author <strong>of</strong> the radiotherapy chapter and responsible for the radiotherapy QA <strong>of</strong> SAKK 16-08 study<br />
in lung cancer (Preoperative chemotherapy and radiotherapy with concomitant Cetuximab in non-small<br />
cell lung cancer (NSCLC) patients with IIIB disease. A multicentre phase II trial).<br />
- Member <strong>of</strong> the writing committee: EORTC trial 22043-30041: Study co-ordinator Pr<strong>of</strong>. Michel Bolla.<br />
“Postoperative external radiotherapy combined with concomitant and adjuvant hormonal treatment versus<br />
post-operative external radiotherapy alone in pathological stage pT3a-b R0-1 N0 / pT2R1N0, Gleason<br />
score 5-10 prostatic carcinoma. A phase III study”.<br />
Local PI & European expert for the radiation oncology quality:<br />
- EORTC 40084-22084 - RTOG 0848: « A Phase III Trial Evaluating Both Erlotinib and Chemoradiation<br />
as Adjuvant Treatment for Patients with Resected Head <strong>of</strong> Pancreas Adenocarcinoma ».<br />
3 US and 3 EU experts review all radiotherapy plans before treatment authorisation<br />
Local-PI:<br />
- Etude EORTC 62092-22092: « A phase III randomized study <strong>of</strong> preoperative radiotherapy plus surgery<br />
versus surgery alone for patients with Retroperitoneal sarcoma (STRASS) ».<br />
b) Radiobiology:<br />
In charge <strong>of</strong> the radiobiology lab <strong>of</strong> CHUV since 2011. Ongoing projects:<br />
• Radio-sensitization effect <strong>of</strong> TAT-RasGAP 317-326 peptide with Pr<strong>of</strong> Widmann, Institute <strong>of</strong><br />
physiology, University <strong>of</strong> Lausanne<br />
• Radio-sensitization effect <strong>of</strong> PP242 with Dr Olivier Dormond, Abdominal surgery department,<br />
CHUV<br />
• Radio-sensitization effect <strong>of</strong> Debio-1143 in vitro and in vivo (confidential). Debiopharm, Lausanne<br />
c) Founding:<br />
Onco Suisse: main co-investigator; 350.000 CHF « Characterization <strong>of</strong> T cell activation and<br />
suppression in melanoma patients by ex vivo analysis <strong>of</strong> myeloid, lymphoid and tumor cells »<br />
EORTC: 200'000 €; IMAGE trial: « EORTC Strategy Meeting 2008»<br />
Amgen: 500’000 CHF; “Concomitant intensity-modulated radiotherapy combined to capecitabine,<br />
mitomycin, and panitumumab in patients with stage II-IIIB squamous-cell carcinoma <strong>of</strong> the anal canal”
4<br />
Debiopharm: 167'000 CHF; « Radiosensitizing effect <strong>of</strong> Debio-1143 in vitro and in vivo ».<br />
Merck Serono: main co-investigator; 147’000 CHF: “Integration <strong>of</strong> cetuximab, in combination with<br />
local radiotherapy, in perioperative chemotherapy <strong>of</strong> resectable and locally advanced gastric cancer: A<br />
pilot phase II-trial”.<br />
d) Patent:<br />
Pending; co-inventor (C. Widmann & O. <strong>Matzinger</strong>): « use <strong>of</strong> a peptide enhancing the ability <strong>of</strong> radiation<br />
therapy to kill cancer cells » (confidential).<br />
11. Publications<br />
Number <strong>of</strong> original peer-reviewed papers: 31<br />
1. Joosten A, <strong>Matzinger</strong> O, Jeanneret-Sozzi W, Bochud F, Moeckli R. Evaluation <strong>of</strong> organ-specific peripheral<br />
doses after 2-dimensional, 3-dimensional and hybrid intensity modulated radiation therapy for breast cancer<br />
based on Monte Carlo and convolution/superposition algorithms: Implications for secondary cancer risk<br />
assessment. Radiother Oncol. 2013 Jan 22.<br />
2. Tsoutsou PG, Sozzi WJ, <strong>Matzinger</strong> O, Ozsahin M. Nomograms Predicting Locoregional Recurrence in the<br />
Subtype Era <strong>of</strong> Breast Cancer. J Clin Oncol. 2012 Dec 26.<br />
3. Perentes J, Bopp S, Krueger T, Gonzalez M, Jayet PY, Lovis A, <strong>Matzinger</strong> O, Ruffieux C, Ris HB, Letovanec<br />
I, Peters S. Ann Thorac Surg. Impact <strong>of</strong> lung function changes after induction radiochemotherapy on resected<br />
T4 non-small cell lung cancer outcome. 2012 Dec;94(6):1815-22.<br />
4. Fairchild A, Aird E, Fenton PA, Gregoire V, Gulyban A, Lacombe D, <strong>Matzinger</strong> O, Poortmans P, Ruyskart P,<br />
Weber DC, Hurkmans CW. EORTC Radiation Oncology Group quality assurance platform: establishment <strong>of</strong><br />
a digital central review facility. Radiother Oncol. 2012 Jun;103(3):279-86<br />
5. Rossier C, Dunet V, <strong>Matzinger</strong> O, Prior JO. PET/CT and radiotherapy: indications and potential applications.<br />
Cancer Radiother. 2012 Apr;16(2):152-63<br />
6. Ozsahin M, Santa Cruz O, Bouchaab H, <strong>Matzinger</strong> O, Tsoutsou PG. Definitive organ-sparing treatment <strong>of</strong><br />
anal canal cancer: can we afford to question it J Clin Oncol. 2012 Feb 20;30(6):673-4; 674-5<br />
7. Tsoutsou PG, Sozzi WJ, <strong>Matzinger</strong> O, Ozsahin M. Personalizing Locoregional Treatment in the Adjuvant<br />
Setting <strong>of</strong> Early Breast Cancer on the Basis <strong>of</strong> Molecular Background: An Exciting Enigma. J Clin Oncol.<br />
2011 Dec 10;29(35):4721-4722<br />
8. Khanfir K, Elhfidh M, Anchisi S, <strong>Matzinger</strong> O, Bieri S, Miriman<strong>of</strong>f RO, Ozsahin M, Zouhair A. Sequential or<br />
concomitant chemotherapy in limited stage small-cell lung cancer. Swiss Med Wkly. 2011 May 31<br />
9. Gonzalez M, Krueger T, Perentes JY, <strong>Matzinger</strong> O, Peters S, Ris HB. Extrapleural pneumonectomy with<br />
venous confluence resection for stage IVA thymic tumors. Ann Thorac Surg 2011;91:941-943<br />
10. Zouhair A, <strong>Matzinger</strong> O, Azria D, Gaye MP, Ugurluer G, El Hfid M, Miriman<strong>of</strong>f RO, Ozsahin M. Postoperative<br />
radiochemotherapy <strong>of</strong> the head and neck: Towards new standards Cancer Radiother 2010;14:217-<br />
221<br />
11. Ozsahin M, Gruber G, Olszyk O, Karakoyun-Celik O, Pehlivan B, Azria D, Roelandts M, Kaanders JH,<br />
Cengiz M, Krengli M, <strong>Matzinger</strong> O, Zouhair A. Outcome and prognostic factors in olfactory neuroblastoma: a<br />
rare cancer network study. Int J Radiat Oncol Biol Phys 2010;78:992-997<br />
12. <strong>Matzinger</strong> O, Heimsoth I, Poortmans P, Collette L, Struikmans H, Van Den Bogaert W, Fourquet A, Bartelink<br />
H, Ataman F, Gulyban A, Pierart M, Van Tienhoven Toxicity at three years with and without irradiation <strong>of</strong> the<br />
internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial<br />
22922/10925). Acta Oncol 2010;49:24-34<br />
13. Pehlivan B, Zouhair A, Luthi F, Bron L, Pasche P, Dragusanu D, Azria D, <strong>Matzinger</strong> O, Miriman<strong>of</strong>f RO,<br />
Ozsahin M. Decrease in hemoglobin levels following surgery influences the outcome in head and neck cancer<br />
patients treated with accelerated postoperative radiotherapy. Ann Surg Oncol 2009;16:1331-1336<br />
14. Pehlivan B, Luthi F, <strong>Matzinger</strong> O, Betz M, Dragusanu D, Bulling S, Bron L, Pasche P, Seelentag W,<br />
Miriman<strong>of</strong>f RO, Zouhair A, Ozsahin M.. Feasibility and efficacy <strong>of</strong> accelerated weekly concomitant boost<br />
postoperative radiation therapy combined with concomitant chemotherapy in patients with locally advanced<br />
head and neck cancer. Ann Surg Oncol 2009;16:1337-1343<br />
15. <strong>Matzinger</strong> O, Zouhair A, Miriman<strong>of</strong>f RO, Ozsahin M. Radiochemotherapy in locally advanced squamous cell
5<br />
carcinomas <strong>of</strong> the head and neck. Clin Oncol (R Coll Radiol) 2009;21:525-531<br />
16. <strong>Matzinger</strong> O, Roel<strong>of</strong>sen F, Mineur L, Koswig S, Van Der Steen-Banasik EM, Van Houtte P, Haustermans K,<br />
Radosevic-Jelic L, Mueller RP, Maingon P, Collette L, Bosset JF. Mitomycin C with continuous fluorouracil<br />
or with cisplatin in combination with radiotherapy for locally advanced anal cancer (European Organisation<br />
for Research and Treatment <strong>of</strong> Cancer phase II study 22011-40014). Eur J Cancer 2009;45:2782-2791<br />
17. <strong>Matzinger</strong> O, Poortmans P, Giraud JY, Maingon P, Budiharto T, van den Bergh AC, Davis JB, Musat E,<br />
Ataman F, Huyskens DP, Gulyban A, Bolla M. Quality assurance in the 22991 EORTC ROG trial in localized<br />
prostate cancer: dummy run and individual case review. Radiother Oncol 2009;90:285-290<br />
18. <strong>Matzinger</strong> O, Gerber E, Bernstein Z, Maingon P, Haustermans K, Bosset JF, Gulyban A, Poortmans P,<br />
Collette L, Kuten A. EORTC-ROG expert opinion: radiotherapy volume and treatment guidelines for<br />
neoadjuvant radiation <strong>of</strong> adenocarcinomas <strong>of</strong> the gastroesophageal junction and the stomach. Radiother Oncol<br />
2009;92:164-175<br />
19. <strong>Matzinger</strong> O, Duclos F, van den Bergh A, Carrie C, Villa S, Kitsios P, Poortmans P, Sundar S, van der Steen-<br />
Banasik EM, Gulyban A, Collette L, Bolla M. Acute toxicity <strong>of</strong> curative radiotherapy for intermediate- and<br />
high-risk localised prostate cancer in the EORTC trial 22991. Eur J Cancer 2009;45:2825-2834<br />
20. Ghadjar P, <strong>Matzinger</strong> O, Isaak B, Behrensmeier F, Stroux A, Rentsch CA, Thalmann GN, Aebersold DM.<br />
Association <strong>of</strong> urethral toxicity with dose exposure in combined high-dose-rate brachytherapy and intensitymodulated<br />
radiation therapy in intermediate- and high-risk prostate cancer. Radiother Oncol 2009;91:237-242<br />
21. Ozsahin M, <strong>Matzinger</strong> O, Zimmermann M, Zouhair A. Radio-chemotherapy in head and neck cancer<br />
(EGFR+). Bull Cancer 2007;94:828-832<br />
22. Ozsahin M, Betz M, <strong>Matzinger</strong> O, Bron L, Luthi F, Pasche P, Azria D, Miriman<strong>of</strong>f RO, Zouhair A. Feasibility<br />
and efficacy <strong>of</strong> subcutaneous amifostine therapy in patients with head and neck cancer treated with curative<br />
accelerated concomitant-boost radiation therapy. Arch Otolaryngol Head Neck Surg 2006;132:141-145<br />
23. Coucke PA, Notter M, Stamm B, Matter M, Fasolini F, Schlumpf R, <strong>Matzinger</strong> O, Bouzourene H.<br />
Preoperative hyper-fractionated accelerated radiotherapy (HART) in locally advanced rectal cancer (LARC)<br />
immediately followed by surgery. A prospective phase II trial. Radiother Oncol 2006;79:52-58<br />
24. Delaloye J, Merlani G, Petignat C, Wenger A, Zaman K, Monnerat C, <strong>Matzinger</strong> O, Beck Popovic M,<br />
Vuichard P, Ketterer N, Tarr PE. Nosocomial nontyphoidal salmonellosis after antineoplastic chemotherapy:<br />
reactivation <strong>of</strong> asymptomatic colonization Eur J Clin Microbiol Infect Dis. 2004 Oct;23(10):751-8. PubMed<br />
PMID: 15605182<br />
25. Michielin O, Udry E, Periard D, <strong>Matzinger</strong> O, Lobrinus JA, Stupp R. Irinotecan-induced interstitial<br />
pneumonia. Lancet Oncol. 2004 May;5(5):322-4. PubMed PMID: 15120670<br />
26. Zouhair A, Azria D, Coucke P, <strong>Matzinger</strong> O, Bron L, Moeckli R, Do HP, Miriman<strong>of</strong>f RO, Ozsahin M.<br />
Decreased local control following radiation therapy alone in early-stage glottic carcinoma with anterior<br />
commissure extension. Strahlenther Onkol. 2004 Feb;180(2):84-90<br />
27. Couke PA, Jichliski P, <strong>Matzinger</strong> O, Ozsahin M, Bulling SM, Zouhair A. Antiandrogen gynecomastia: an<br />
inescapable harm Radiotherapy: a simple and efficient solution! Rev Med Suisse Romande. 2004<br />
Jan;124(1):51-4<br />
28. Henchoz E, D'Alessio DA, Gillet M, Halkic N, <strong>Matzinger</strong> O, Goy JJ, Chioléro R, Tappy L, Schneiter P.<br />
Impaired insulin response after oral but not intravenous glucose in heart- and liver-transplant recipients.<br />
Transplantation. 2003 Sep 27;76(6):923-9<br />
29. Delarue J, <strong>Matzinger</strong> O, Binnert C, Schneiter P, Chioléro R, Tappy L. Fish oil prevents the adrenal activation<br />
elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95<br />
30. <strong>Matzinger</strong> O, Schneiter P, Tappy L. Effects <strong>of</strong> fatty acids on exercise plus insulin-induced glucose utilization<br />
in trained and sedentary subjects. Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E125-31<br />
31. Rigalleau V, Binnert C, Minehira K, Stefanoni N, Schneiter P, Henchoz E, <strong>Matzinger</strong> O, Cayeux C, Jéquier E,<br />
Tappy L. In normal men, free fatty acids reduce peripheral but not splanchnic glucose uptake. Diabetes. 2001<br />
Apr;50(4):727-32<br />
Book chapter:<br />
<strong>Matzinger</strong> O. “Esthesioneuroblastoma” in: Management <strong>of</strong> Rare Adult Tumours, coordinated by Y. Belkacémi, M.<br />
Ozsahin, and R.O. Miriman<strong>of</strong>f”. Ed. Springer 2010
6<br />
Invited presentations (only international conferences):<br />
ESTRO 2013 (European society for radiation oncology): « Spincter preservation in anal cancer »<br />
EBCC 2012 (European Breast Cancer Conference) 2012. « Role <strong>of</strong> radiotherapy in advanced breast cancer »<br />
SAMO 2012 (Swiss Academy <strong>of</strong> Multidisciplinary Oncology): « Modern technique <strong>of</strong> radiotherapy in resectable<br />
NSCLC, an alternative approach to surgery »<br />
ECCO 2011 (European Multidisciplinary Cancer Congresses): « Clinical Trial design in surgical and radiation<br />
oncology »<br />
ICTR 2009 (International Conference on Translational Research and Pre-Clinical Strategies in Radiation<br />
Oncology): « The Value <strong>of</strong> PET in Gastro-esophageal Cancer »<br />
EGAM (EORTC group annual meeting) 2009: « Toxicity <strong>of</strong> Internal mammary and medial supraclavicular lymph<br />
node chain irradiation in stage breast cancer »<br />
EGAM 2009: « Acute toxicity <strong>of</strong> curative radiotherapy for localized prostate cancer »<br />
Other oral presentations<br />
ICHNO 2013: D. Viertl, F. Perillo-Adamer, S. Rigotti, H. Maby El Hajjami, A. Vaslin, G. Vuagniaux, C Zanna, O.<br />
<strong>Matzinger</strong>. Preclinical rationale for combining the Smac-mimetic Debio 1143 with concurrent chemioradiotherapy<br />
in LA-SCCHN.<br />
ASTRO 2012 (American society for radiation oncology): D. Viertl, A. Annibaldi, F. Buchegger, M. Özsahin, R-O<br />
Miriman<strong>of</strong>f, Ch. Widmann, O. <strong>Matzinger</strong><br />
“Tumor Radiosensitization Induced by a-RasGAP Derived Peptide and its Pharmacokinetic in Mice”<br />
4th Symposium on Novel Targeting Drugs and Radiotherapy 2012, Toulouse, France: D. Viertl, A. Annibaldi, F.<br />
Buchegger, M. Özsahin, R-O Miriman<strong>of</strong>f, Ch. Widmann, O. <strong>Matzinger</strong>. “TAT-RasGAP317-326 abolishes in vivo<br />
radio-resistance <strong>of</strong> p53 defective tumor “<br />
ESTRO 2012: Viertl D, Annibaldi A, Widmann C, <strong>Matzinger</strong> O. “Radiosensitizing effect <strong>of</strong> a RasGAP derived<br />
peptide on cell survival in human cancer cells in vitro and in vivo”<br />
SASRO 2012 (Scientific Association <strong>of</strong> Swiss Radiation Oncology): David Viertl, Allessandro Annibaldi, Mahmut<br />
Özsahin, René-Olivier Miriman<strong>of</strong>f, Christian Widmann, <strong>Oscar</strong> <strong>Matzinger</strong>. « In vitro and in vivo tumor<br />
radiosensitization induced by TAT-RasGAP317-326 peptide »<br />
ICTR 2012 (International Conference on Translational Research in Radiation Oncology) : Viertl D, Annibaldi A,<br />
Widmann C, <strong>Matzinger</strong> O. « A TAT-RasGAP derived peptide efficiently sensitizes cancer cells to radiotherapy, an<br />
in vitro and in vivo study »<br />
ESTRO 2011: <strong>Matzinger</strong> O. « EORTC Radiotherapy Quality Assurance Platform: Establishment <strong>of</strong> an Integrated<br />
Central Review Facility »<br />
ECCO/ESMO, 2009: <strong>Matzinger</strong> O « Acute toxicity <strong>of</strong> curative radiotherapy for intermediate and high risk<br />
localized prostate cancer in the EORTC trial 2299 »<br />
SASRO (Scientific association <strong>of</strong> Swiss Radiation Oncology), 2007: <strong>Matzinger</strong> O « Limited Stage Small Cell Lung<br />
Cancer: Results <strong>of</strong> Combined Modality Treatment »<br />
Abstracts in conferences:<br />
SASRO 2012: H. Bouchaab, S. Peters, H. B. Ris, P. Tsoutsou, M. Pachoud, R. O. Miriman<strong>of</strong>f, M.<br />
Ozsahin, O. <strong>Matzinger</strong> : « Accelerated hyp<strong>of</strong>ractionated radiotherapy in inoperable lung cancer using<br />
Tomotherapy: The Lausanne experience »<br />
SASRO 2012: D. Viertl, A. Annibaldi, M. Özsahin, R.-O. Miriman<strong>of</strong>f, C. Widmann, O. <strong>Matzinger</strong> :<br />
« In vitro and in vito tumor radiosensitization induced by TAT-RasGAP317-326 peptide »<br />
ASTRO 2011: Viertl D, Wiedmann ,Annibaldi A, <strong>Matzinger</strong> O : « A Cell Permeable Rasgap-derived Peptide<br />
Sensitizes Cancer Cells To Radiotherapy »<br />
ASTRO 2011: <strong>Matzinger</strong> O, Bouchaab H, Ozsahin M, Miriman<strong>of</strong>f O. « Helical tomotherapy in the treatement <strong>of</strong><br />
anal canal caner »
7<br />
ISREC Symposium 2011: Viertl D, Annibaldi A, Miriman<strong>of</strong>f R.-O, Widmann C, <strong>Matzinger</strong> O : « A Cell<br />
Permeable RasGAP-derived Peptide Sensitizes Cancer Cells to Radiotherapy »<br />
SASRO 2011: Cosinschi A, Khanfir K, Boujelbene N, Herrera F, Pachoud M, <strong>Matzinger</strong> O : Ozsahin M. « Carotid<br />
sparing in T1-T2 N0 glottic cancer using helical tomotherapy »<br />
ESTRO 2009: Ugurluer G, Ballerini G, Letenneur G, Lacombe C, Pissaturo O, <strong>Matzinger</strong> O : Montemurro M,<br />
Zouhair A, Miriman<strong>of</strong>f RO, Ozsahin M. « Helical tomotherapy (HT) for the treatment <strong>of</strong> anal canal cancer:<br />
Preliminary clinical results, and dosimetric comparison between HT and intensity-modulated or 3D conformal<br />
radiotherapy »<br />
SASRO 2008: <strong>Matzinger</strong> O, Ozsahin M, Luthi F: « Induction Chemotherapy followed by concomitant<br />
chemotherapy and IMRT for nasopharyngeal carcinoma »<br />
ASCO 2008: Ozsahin M, Pachoud M, Moeckli R, Letenneur G, Lacombe C, Montemurro M, Betz M, <strong>Matzinger</strong><br />
O, Miriman<strong>of</strong>f RO, Zouhair A : « Helical tomotherapy in the treatment <strong>of</strong> anal cancer: Preliminary results »<br />
ASTRO 2007: <strong>Matzinger</strong> O, Ozsahin M, Khanfir K, ElHfid M, Peters S, Pachoud M, Bieri S, Miriman<strong>of</strong>f R.O.<br />
and Zouhair A: « Sequential or Concomitant Chemotherapy and 3D Conformal Radiation Therapy with Dose-<br />
Volume Histogram Assessment in Limited Disease Small Cell Lung Cancer »<br />
ASTRO 2007: Pehlivan B, Zouhair A, <strong>Matzinger</strong> O, Luthi F, Bron L, Pasche P, Seelentag W, Bulling S,<br />
Miriman<strong>of</strong>f R.O. and Ozsahin M: « Accelerated Weekly Concomitant Boost Postoperative Radiation Therapy<br />
Combined to Concomitant Chemotherapy in Patients With Locally Advanced Head and Neck Cancer »<br />
ECCO 2007: Zouhair A, Dragusanu D, <strong>Matzinger</strong> O, Pehlivan B, Khanfir K, Ris H.B, Stupp R, Moeckli R,<br />
Miriman<strong>of</strong>f R.O. and Ozsahin M: « Postoperative 3D Conformal Radiation Therapy With Dose-Volume Histogram<br />
Assessment in Non Small-Cell Lung Cancer »<br />
ECCO 2007: Ozsahin M, Pehlivan B, <strong>Matzinger</strong> O, Luthi F, Bron L, Pasche P, Seelentag W, Bulling S, Miriman<strong>of</strong>f<br />
R.O. and Zouhair A: « Accelerated weekly concomitant boost postoperative radiation therapy combined to<br />
concomitantchemotherapy in patients with locally advanced head and neck cancer »<br />
ASTRO/ASCO/AHNS (Multidisciplinary Head and Neck Cancer Symposium) 2007: <strong>Matzinger</strong> O, Ozsahin M,<br />
Bron L, Luthi F : « Pilot study <strong>of</strong> induction chemotherapy followed by concomittant chemotherapy and intensitymodulated<br />
radiotherapy or tomotherapy for nasopharyngeal carcinoma »<br />
ASTRO 2004: <strong>Matzinger</strong> O, Miriman<strong>of</strong>f R.O., Zouhair A. and Ozsahin M: « Decrease in the Hemoglobin Level<br />
Influences the Outcome in Head and Neck Cancer Patients Treated with Postoperative Accelerated Radiation<br />
Therapy »<br />
SASRO 2004: Ozsahin M, Betz M, <strong>Matzinger</strong> O, Azria D, Stupp R, Luthi F, Pasche P, Miriman<strong>of</strong>f RO, Zouhair<br />
A: « Feasibility and efficacy <strong>of</strong> subcutaneous amifostine in head and neck cancer treated with curative radiation<br />
therapy »<br />
ICHNC 2004 (International Conference on Head and Neck Cancer) Ozsahin M, Betz M, <strong>Matzinger</strong> O, Azria D,<br />
Luthi F, Pasche P, Miriman<strong>of</strong>f RO, Zouhair A. « Feasibility and efficacy <strong>of</strong> subcutaneous amifostine in head and<br />
neck cancer patients treated with curative radiation therapy »<br />
ASTRO 2004: Ozsahin M, Pasche P, Luthi F, Azria D, Betz M, <strong>Matzinger</strong> O, Miriman<strong>of</strong>f RO, Zouhair A:<br />
« Decreasing hemoglobin level during surgery influences the outcome in head and neck cancer patients treated with<br />
postoperative accelerated radiotherapy »