Matching in case control studies - The INCLEN Trust

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Analysis of matched case control studies with more than one control per case • Sort out the sets according to the exposure status of the cases and controls Example for 1 case / 2 controls Sets with case exposed: +/++, +/+-, +/-- Sets with case unexposed: -/++, -/+-, -/-- • Count reconstituted case-control pairs for each type of set • Multiply the number of discordant pairs in each type of set by the number of sets • Calculate odds ratio using the f/g formula Matched analysis
The old 2 x 2 table... Cases Controls Total Exposed a b L1 Unexposed c d L0 Total C1 C0 T Odds ratio: ad/bc Matched analysis
Page 1 and 2: Arranged marriage Matching in case
Page 3 and 4: Key elements • The concept of mat
Page 5 and 6: Matching: concept • Confounding i
Page 7 and 8: Consequences.... • The problem:
Page 9 and 10: Types of matching strategies • Fr
Page 11 and 12: Matching: True statements Matching
Page 13 and 14: Example: Risk factors for microspor
Page 15 and 16: Matched analysis by set (Pairs of 1
Page 17 and 18: The Mantel-Haenszel odds ratio... O
Page 19: …and the analysis can be done wit
Page 23 and 24: The Mac Nemar chi-square Chi 2 McN=
Page 25 and 26: Matching: Inconvenience • Must be
Page 27 and 28: Hidden matching (“Crypto-matching
Page 29 and 30: Breaking the match • Rationale

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