Matching in case control studies - The INCLEN Trust

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Matching for operational reasons • Outbreak investigation setting • Friends or neighbours controls are a common choice • Advantages: • Allows identifying controls fast • Will take care of gross confounding factors • May result in some overmatching, which places the investigator on “the safe side” Pro and cons
Breaking the match • Rationale • Matching may limit the analysis • Matching may have been decided for operational purposes only • Procedure • Conduct matched analysis • Conduct unmatched analysis • Break the match if the results are unchanged Pro and cons
Page 1 and 2: Arranged marriage Matching in case
Page 3 and 4: Key elements • The concept of mat
Page 5 and 6: Matching: concept • Confounding i
Page 7 and 8: Consequences.... • The problem:
Page 9 and 10: Types of matching strategies • Fr
Page 11 and 12: Matching: True statements Matching
Page 13 and 14: Example: Risk factors for microspor
Page 15 and 16: Matched analysis by set (Pairs of 1
Page 17 and 18: The Mantel-Haenszel odds ratio... O
Page 19 and 20: …and the analysis can be done wit
Page 21 and 22: The old 2 x 2 table... Cases Contro
Page 23 and 24: The Mac Nemar chi-square Chi 2 McN=
Page 25 and 26: Matching: Inconvenience • Must be
Page 27: Hidden matching (“Crypto-matching

Matching in case control studies - The INCLEN Trust

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